Function
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic (PubMed:27416025). All 20 genes in the cluster are up-regulated to some extent by lcsF, with the exception of lcsL and lcsP, which are down-regulated (PubMed:27416025).
Sequence
MAPASSNPGPYSLPDKDEVQLSAEDDWTRVKDRKEKKRIQNRVAQRSYRSRMKARLGELQSRLQAHEEQKAKEEAERCDPSPPSPPSSSATGLHLHTTPPSGNNAGANDTEPSSINSASPPTPPDVVGDLDPSQHAKAIDQFSHQMDMAGNDDSQWFLDSTSLLQHGDTSSYIQPSVPTPPVSLSQCPPMPAYMPEGPRNPNDGPASLSQSILQDCLRFQIQLLAKINNPSEATSTTHKEEGSAAKSPGALQQSHWSSCATNPAAAAQNMMPSTNMARGNSFSVLPADFHNLDDMMELTSTGDLPNATWRPSQQFSGPETTPRSHNAENPTQQQSPINDDTPSTTQHGAVPDCYNAFVAKSSAQASSLGMEERLEAAIEGLEALGFTSVDSFAEAYYSSSFDESSHLAAEQSMSRKRRLPRMLSQILDSAQSWDPWDRRGLNEEVLRTAESLLVAEGKSMDEKSLEASISGLMQATEGSSKPTPPQQNVTGMKRVLQNELPNLWPVMMALAGGNRASRQRDRSNMVLAAILILHCSSKMTKQKLLEFLDVCL