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larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Alkaliphilus metalliredigens (strain QYMF)
Length
421 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
46.928 kDa
Sequence
MSNQLYLECYSGISGDMAVSALLDLGADVDVLKKSLHSLNLEGYEINIGRRQKCGIDACYFDVVLEGEANHHHDHQEKHDHHHGGHPVHRNIKDIYEIIDNSQISDRSKILSKKIFHVVAKAEAKAHGIAIDEVHFHEVGAVDSIVDIVAAAVCLDNLEINEVMISDLYEGSGHVKCQHGVLPVPVPAVANIVMDNGLNLRITDTRGELVTPTGAAIAAAIKTKDTLPASYGIKKIGIGSGTKDLPKANILRAYIIEDNRNYPKKTVAVEDHIDSLDDGEAWVLETNIDDATGESLGFTMERLLENGANDVFFSPIYMKKNRPAYKLSVICTKENVKIMESIIFKNTTTIGIRKHKIRRTVLKREVTTIDTKYGQVRVKVCEFENETYYYPEYEDIKRICNETGLGFQRVYDEVEKTKTVG
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Length
420 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
46.391 kDa
Sequence
MQTLYLDAFSGISGDMFLGALLDLGLDFEQLKTELAKLHVHGYELTQQREAQSSIYGTSFDVQVAGGKDHGFVEHHHHQHEAGHHHDHEARHLADIEALIDGSDLSDTVKHHAKAIFMEIAQAEAAVHHMPLAEVHFHEVGALDSIVDIVGCCIGLELMQIDTIMASPLSDGSGFINVAHGQMPVPVPAVMQMRVGSAIPIQQRLDVHTELITPTGMGLVKTLVREFGPLPENAVPTRVGYGFGKRDTGGFNALRAVLFEKKKLSQQIVNRTADAVLMIEANLDDQTGEGLGYVMNQLLTAGAYDVFFTPIQMKKDRPATKLTVLGNVNDKDLLTKLILQETTTIGVRYQTWQRTIMQRHFLTVATPYGDVQVKVATYQDIEKKMPEYADCAQLAQQFHIPFRTVYQAALVAVDQLDEEA
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
420 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
47.918 kDa
Sequence
MRILYYDCFCGISGDMNLAALVDLGVPKKYLIDELLKLNLGSEYEIKIEKGQKLGITGTRVDVILKDEHHNKHELEEVLHNHEHKHNHHEIKNDEPAHSHEHHHRSLRDIEEIINSSTLNDKVKKLSLNIFMKVAEAEAKVHGRELYEVHFHEVGAVDSIVDIVGAAICIDYLKVDKILASRVQVGGGFVRCAHGIMPVPAPATVEILKNIPINTGIVQFETTTPTGAAILAANVKEFTQKLDFIIKKTAYGIGHRDLEIPNVLRVYLGEEESFQDIENQYILETNIDDMNPEIYGYVEEKLFKVGALDVFKTPICMKKGRPGIKLSVLTNEKSEREVLDVIFEETTSIGVRRYKVEKIMLKREFSKVKTEFGDITVKKAYYKGELVKYKPEYEECKDIAREKNVSIHKVYKAVYKQDLK
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Geobacillus kaustophilus (strain HTA426)
Length
411 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
45.196 kDa
Sequence
MKILYLDCFSGISGDMMVGALVDAGVPSEKIEVELKKLSLSGYKLQWGKVVKKGISATKFDVIIQESIEGGHHHQSHHAHRHYSDIIDMIRRSELSEEVKQRAGQIFHCIAVAEAKIHGIPVENVHFHEVGAVDSIVDIVATAIALTELHIDYIISAPIPLGHGSIRCAHGVYPVPAPATLEILQGVPVVSNHLPFELTTPTGAGIVKSQVNSYGPLPSMKISAIGYGAGTRDLPDQPNVLRVVIGEETRITSSGPSLFHSKEETVYILECQLDDMPGEALGYVMDGLFQKGALDVFYTPVFMKKNRPGVLLTVLTSATHVEQCEQFMLKETTTLGIRKDIWVREVLERDVVTVATSYGNIRVKQAIHKGKVIRQMPEYEDVKEAALTHQVAFLDVYAEAAEQARRRIKGE
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Length
407 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
45.633 kDa
Sequence
MRILYFDCFAGASGDMILGALLDLGIDVGIFKRELAGLNLDGFDIAVEKKVINSIAVTDVNVIVKEECNHHTGHHHHCERNLADIEKIIDESSLKDNVKRLSKKIFSEIARAEAKVHNKSIEDVHFHEVGAIDSIVDIVGTAICLDLLKVDKIYSSPMHDGTGFIECQHGKLPVPVPAVLEMLKESNIPYITEDVNTELLTPTGLGIIKCVASKFGPMPPMTIEKVGYGAGKRQTGRFNALRCILGNAKEKEKIDDEICMLETNIDDMNPEILGYVMNRLFENGALDVFYTPVYMKKNRPGVLLTVLTDKEHEEKLVDIILTETTTLGIRKTTAQRYVLEREIKHVNTEFGKIRVKESSFGDYKKYSPEFEDCKKVAQELKIPLSKVYDAVNKAILVFEERNENALQ
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Akkermansia muciniphila (strain ATCC BAA-835 / Muc)
Length
406 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.217 kDa
Sequence
MRALVYDCSAGISGDMNLAALIDLGADRENLERELSKLHVHGEWKLECRPAQQHGIRGTRIDVLTEEEGHSGSSHAHHHRTMADIRKLIETSALSNTVKRTALSIFTLLAEAEARVHGTTSEEVHFHEVGAVDSIIDIAGAAICLEMLRVDTVFTGPVELGSGTVTCQHGTMPVPAPATALLAKHFRATLNGTTHEATTPTGAAYIAALAQPVPSPLAGRITATGYGIGHRQGLPVPNILRVMLVETEEEETSPELLTELCANIDDMTPEQTAYLAEKLMEAGALDTWQESVCMKKGRLAVKVCALCQPEQTDRVREAFFRHSSTPGIRQHGMLRHILRRESAPVHTPHGTVHVKTSFMHGRPHYRKAEFEDCRILAEKTGLPLGQCQLMGLFPTSSHDNDATDSV
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Length
402 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.761 kDa
Sequence
MKAAYLDCFSGISGDMLLGALVDAGLDFNLLQRDLAGLDLDEYELYEQKVLKQGIRGTQIHVHALEGHVHRHLSDIQAIIGRSALPPQVKEKSLEIFTRLGKAEAKIHGTDIEQIHFHEVGAVDAIVDIVGAVIGFWRLGIEKVFASPIHVGKGFVKAAHGLLPVPAPATLELLTGVPIYAQDVEGELATPTGAAIVTAYCREFGPFPKIRVERVGYGAGVKDLTIPNLLRLTVGELADEDKGQEGIREGEALTLEVNIDDMNPECYDYLFEKLFQAGAMDVYIQTIQMKKNRPAVLLTVQTPYHKLEEMRKILFQETTTIGLRVYPIKKYMLPYELFTVETNYGSAKVKVAFMEGRACTVSPEYEDCRRLARLTGEPLKQIYEEIKEKAKILLYSTKYPID
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Desulfitobacterium hafniense (strain Y51)
Length
402 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.769 kDa
Sequence
MKAAYLDCFSGISGDMLLGALVDAGLDFNLLQRDLAGLDLDEYELYEQKVLKQGIRGTQIHVHALEGHVHRHLSDIQAIIGRSALPPQVKEKSLEIFTRLGKAEAKIHGTDIEQIHFHEVGAVDAIVDIVGAVIGFWRLGIEKVFASPIHVGKGFVKAAHGLLPVPAPATLELLTGVPIYAQDVEGELATPPGAAIVTAYCREFGPFPKIRVERVGYGAGVKDLTIPNLLRLTVGELADEDKGQEGIREGEALTLEVNIDDMNPECYDYLFEKLFQAGAMDVYIQTIQMKKNRPAVLLTVQTPYHKLEEMRRILFQETTTIGLRVYPIKKYMLPYELLTVETNYGSAKVKVAFMEGRACTVSPEYEDCRRLARLTGEPLKQIYEEIKEKAKILLYSTKYPMD
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Length
402 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
45.064 kDa
Sequence
MRILYLDPFSGISGDMFLGLLVDLGVDPEKIKSRLEKLNVEFDLVVKKVNKKGVTATKVDVVFPRKEHHEDHIVSDHDHHHHHGRHLSEIVEVLSRLEDPLKEKAIRMFEALAEAESKIHGLSKEKVHFHEVGAMDAVIEIAGAVVGLELLEVEKVFCGTVNTGSGFVMTEHGRYPVPAPATAELLKGIPIYMDQKVRAELVTPTGAVILKILVDEFRTPILRVEKVGYGAGTMDLEIPNVLRGYLGYIEPSERTGDVLIETNVDDMNPQLFGHLMERLFEAGAKDVFFTPIYMKKNRPAVKVSVLCHESKKDEILKLLFKESTSIGARVFYPEKVEATRTLKTVKTEYGEIPVKIASFDSEIVNISPEYEACKKVAQEKGIPLKEVYRAVYKSVSEVRNDV
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Thermotoga sp. (strain RQ2)
Length
402 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.859 kDa
Sequence
MRILYLDPFSGISGDMFLGLLVDLGVDPEKIKSRLEKLNVEFEFVVKKENKKGVTATKVDVVFPGKEHHEDHIVSDHDHHHHHGRHLSEIVEVLSRLEDPLKEKAIRMFETLAEAESKIHGLSKEKVHFHEVGAMDAVIEIAGAVAGLELLGVEKVFCGTVNTGSGFVMTEHGRYPVPAPATAELLKGIPIYVDQKVRTELVTPTGAVILKSLVDEFRTPILRVEKVGYGAGTMDLEIPNVLRGYLGYIEPSERTGDVLIETNVDDMSPQLFGHLMERLFEAGAKDVFFTPIYMKKNRPAVKVSVLCHESKKDEILKLLFKESTSIGARVFYPEKVEATRTVKTVKTEYGEIPVKIASFDSEIVNISPEYEACKKIAQEKGIPLKEVYRAVCKSVSEVRDDV
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Length
399 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
45.124 kDa
Sequence
MKILYYDCFCGISGDMNLAALIDLGVPKEYLMEELSKVNLNSEYEMKIERSVKLGITGTRVDVKLNESSHGEEEHGHDHYHHHRKLKDIEKIINSSHLSDKVKNISLGMFMKIAEAEAKIHGKSLCEVHFHEVGAIDSIVDLVGAAICIDYLKVDRIIASPVQVGGGFVECSHGIIPVPAPATTEILKNIPISTGIVQFETTTPTGAAILAVNVEEFTSKIDFSIEKIGYGIGHRDLEIPNVLRVYLGEQERSEKVEEQYILETNIDDMNPEFYEYVQERLFEVGALDVFKTPIYMKKGRPGINLSVLISEKGEKDVLDVIFEETTSIGVRKHKVEKIMLNRDFSKVKTEYGDITVKKSYYKGKLVKYKPEYEECKAIAKEKNISIDKIYKVVYRQDLN
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Length
397 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.444 kDa
Sequence
MEKILYLDPFSGIAGDMFLGLLVDLGVDPEELKKRLSKLGVEFELRIRKVNKKGITATKVDVVFPGKEHHEDHIDHEHHGRHLSEIMKILERLEDPAREKATEMFETLAEAESKVHGLPKEKVHFHEVGAMDAVIEIAGAVVGLELLGVERVFCGAVNTGSGFVMTEHGRYPVPAPATAELLKGIPIYMDQKVRAELVTPTGAVILKELVDEFGTPILRIEKVGYGAGTVDLEIPNVLRGYLGFLEGKSERDILIETNVDDMNPQLFGYLMEKLFETGAKDVFYTPIYMKKNRPAVKVSVLCSEEKRDQILKVLFKESTSIGARVFHLEKVEAPRKVISVETEYGKIPVKVAYFDSEVVNVSPEYEACKKIAQEKEVPLKEIYNAVYRKISEVQGNV
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Corynebacterium glutamicum (strain R)
Length
397 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
42.232 kDa
Sequence
MGLWIDATAGVAGDMLLGALIDAGAELEKIQQVVEAVIPGDVLLRAEEVVRQGQRGIKLHVEAQHEHHHHRHLSTIKELLVNADIPEQTKQDALGVFELIAIAEGKVHGIDPEKIHFHEVGAWDSIADIVGVCEAIRQLNPGLIAASPIALGFGRIKAAHGDIPVPVPAVAELVKGWPTQTGALMESTEPVGELATPTGVALIRHFATQDGPFPGGIINEVGIGAGTKDTAGRPNVVRAVLFSTSGKAASNPDTRTLVQLEANVDDQDPRLWTGVIESLLVAGAVDAWLTPILMKKGRPAHTVSALVDSSAVEAVKTALFASTTTFGIRSWEVEREGLDRRFEQVEVDGHTINIKIGSRNGHDISAQPEFEDIRSAAVALGISEREVVARIPQGTTE
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Length
396 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
42.016 kDa
Sequence
MKIAYFDCFSGISGDMCLGALIACGLSQDELTSGLKGLGLEGWELRVREVKQHSIAATDVAVQVTGSQPHRHLADILGLINNSSLPAPVKEKSAAVFKNLARAEGQVHGIDASQVHFHEVGAVDAIIDIVGSILGLHLLGIEKVISSPLPAGSGWVDCRHGKLPVPAPATLYLLQGYPVYGTEDKAELVTPTGAALITTLADSFGPFPAMNLTRVGFGAGKTELPHPNLLRLALGEINSGQLEGEESSLVIETTIDDMNPEFFPALLEETMAAGAVDAFFTPVQMKKGRPGILFTALCPENKLAAVAAAIFTHSSTLGLRFRRDQRLVCQRRMAEVVTPYGTVPVKLGLYRDPTGQVITNIAPEYESCRQIAKSAGAPLKEVYAAALAAARALKAF
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
395 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.176 kDa
Sequence
MTKALYLDCHAGIAGDMLLSALVDLGAHPEDIESELKKLPLDQFKLHFQKRVKQGIHAMTLNIDVKESNHHRHVNDIFKMIDDSTLPERVKYRSKKIFEIIGQAEAKIHGMSFEEVHFHEVGAMDSIIDIIGGCIALEQLGINTLYCSAIPTGHGKIHIAHGIYPIPAPATAEILKGIPIAHFDVQSELTTPTGAAFAKGLVSSFGPFPSATIQHIGYGAGSKDFNFPNILRVIQFDSEFEQQDSVQVIECQIDDMTPEALGDFMNNALEQGALDAYYTPIFMKKSRPSTQLTLICKLHDKIYFEQLILQETSSLGVRSTSVNRKILNRAFKILSTQHGTVSIKFGLQNGKIMKMKPEYEDLKKMAKTTNQPFQVIHNEVLQQLYQTYRIGDILQ
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
395 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
44.129 kDa
Sequence
MTKALYLDCHAGIAGDMLLSALVDLGANPEDIESELKKLPLDQFKLHFQKRVKQGIHAMTLNIDVKEANHHRHVNDIFKMIDDSTLPERVKYRSKKIFEIIGQAEAKIHGMSFEEVHFHEVGAMDSIIDIIGGCIALEQLGINTLYCSAIPTGHGKINIAHGIYPIPAPATAEILKGIPIAHFDVQSELTTPTGAAFAKGLVSSFGPFPSATIQHIGYGAGSKDFDFPNILRVIQFESEFEQQDSVQVIECQIDDMTPEALGYFMNNALEQGALDAYYTPIFMKKSRPSTQLTLICKLHDKTYFEQLILQETSSLGVRSTSVNRKTLNRAFKILSTQHGTVSIKFGLQNGKIMKMKPEYEDLKKIAKTTKQPFQVIHNEVLQQLYQTYHIGNILQ
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
394 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
42.353 kDa
Sequence
MGLWIDATAGVAGDMLLGALIDAGAELEKIQQVVEAVIPGDVLLRTEEVVRQGQRGIKLHVDAQHEHHHHRHLSTIKELLVNADIPEQTKQDALGVFELIAIAEGKVHGIEPEKIHFHEVGAWDSIADIVGVCEAIRQLNPGLIAASPIALGFGRIKAAHGDIPVPVPAVAELVKGWPTQTGALMESTEPVGELATPTGVALIRHFATQDGPFPGGIINEVGIGAGTKDTEGRPNIVRAILFNTSRSNPDTRTLVQLEANVDDQDPRLWPGVIEILFAAGAVDAWLTPILMKKGRPAHRVSALVDSSEVEAVKTALFAATTTFGIRSWEVEREGLDRRFEQVEVDGHTINIKIGSRDDQVISAQSEFEDIRSAAVALGISEREVVARIPQGTTE
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Length
393 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
40.24 kDa
Sequence
MTTAWVDASAGASGDMLLGALVGAGVPVAVLQAAVDAVAPEPVTLRVEHVRRGGLAATRCHVEVTDTARHRTWRDVRTLLAAADLADDVRGLALRVFERLATAEATVHGTSPDDVHFHEVGALDAIADVTGVVAGFVHLGATAVTVSPVAVGSGSVSTAHGLLPVPPPAVAELLRGVPSYAGAATMETCTPTGAALLTTLATAYGPQPAMSVDTIGVGAGGRDPEGHPNVLRLFVGVPADAGGGPLLLECNVDDLDPRVWPAVIAALLEAGASDAWLTPILMKKGRPAHTLSALVDAGRAAGVRAAIFRQTSTIGLREQPLTKHALEREIVAVDVDGQRIAVKLARHDGAVVNAQPEYDDVARAAADLDRPVADVLAEAVARGRAFLTPGDKI
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
391 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
43.133 kDa
Sequence
MTNGLYLDCHAGIAGDMLLSSLVDLGADVDYVHQHLLSLPLDQFSLNFAKKNKQGIQAMGLTIDFEEAHHHRKASDIFNMINESTLPNRVKERSMLIFDVIAQAEAKIHGMKIEDVHFHEVGAMDSIIDIIGSCLALEDLGIDEIKSSPVPTGNGKIKIAHGIYPIPAPATAEILKDIPLATFDVQSELTTPTGAAFIKALATHIGPLSAVSMSNIGYGCGTKDFEFPNVIRAIQYTATETTPNQVQVLECQIDDMTPETLGYFIEQVINEGALDAFYTPITMKKSRPATQLTVISSVTQAKEFEDFILKHTTSLGVRSYAVNRKILHRQFQTIHTTYGAILVKLAMKDNKIIKAKPEFEDVKNAALHSGQSFTNVYNDIQNEVRKHIQID
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC

Gene
larC
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
391 amino acids
Function
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Similarity
Belongs to the LarC family.
Mass
41.558 kDa
Sequence
MSLWIDASAGVAGDMLLGALVDAGADLDQIQQVVDAVVPGDVRLTSEVVQRAGQRCLKVEVHTTHEHHPHRTWTTIRTMLQEADLPDQTHADALAVFELIAIAEGAVHGVDPETIHFHEVGALDSIADIVGVCEAIRQLGQTRISSSPIALGFGRVQAAHGDIPVPVPAVAELARDWPTLSGAVGGSPEPVGELATPTGVALVRHFASQAGPLPDGAITTIGVGAGTKDMPGRPNITRVLLLDDAAPNADTGKLVQLEANIDDMDARLWPGVLEQLLDSGARDAWLTPIIMKKGRPAHTIHVLAAASEVEMVKQVLFAHTTTFGVRSWAVDREGLDRRWETVHVDGHEVRVKIGSRGGVDQTTQPEFEDVRAAAQALGISESEVLRRAQGQ
Protein
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein: larC