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laeA

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
498 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:21897021, PubMed:22083274, PubMed:23729383). Controls the expression of the kojic acid gene cluster, producing a secondary metabolite used as a skin-lightening agent, an antioxidant, and an antibiotic (PubMed:21897021).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
57.535 kDa
Sequence
MSSEKQPFYEENGRMYHAYRKGVYMLPCDEQEQDRLDIFHKLFTVARVSDGLMYAPHPRNGRFLDLGCGTGIWAIDVANKYPDAFVVGVDLAPIQPSNHPKNCEFYAPFDFESPWAMGEDSWDLIHLQMMFGNGQTGQRLPAMASPPHDSYYSQSLASSRSRNNSDAMDIYAITDRDPPAREPSGYSQWYRNGSPSVNSIHSKSSEKQPFYEENGRMYHAYRKGVYMLPCDEQEQDRLDIFHKLFTVARVSDGLMYAPHPRNGRFLDLGCGTGIWAIDVANKYPDAFVVGVDLAPIQPSNHPKNCEFYAPFDFESPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRPLEGLAIRQWYQYLKQATQDAMRPINHNSRDTIRDLQEAGFTDIDHQMVGLPLNPWHQDEHERKVARWYNLAVSESIESLSMAPFSRIFNWDLDRIRRISSEVKSEAFNKEIHAYNILHIYQARKPAN

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Length
427 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:18952140, PubMed:22439693). Controls the expression of the penicillin gene cluster (PubMed:18952140, PubMed:20543063, PubMed:22439693, PubMed:23089625, PubMed:23264641). Controls benzylpenicillin production, but is not involved in the biosynthesis of the alkaloid roquefortine C (PubMed:18952140). Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879). Positively controls the expression of the transcription factor atfA (PubMed:25557366). Regulates also asexual differentiation (PubMed:18952140, PubMed:23264641).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
48.548 kDa
Sequence
MSYRESSGSFPAPDRTSLPKMFTNGDSRLRHLPPISSPPPPKRYKSESTPGSDAGHSRYYSHSVASDRTRSRQPSSAMDLYTLIDRDPVDKDPRRNARFTSNGSVATQASHASNASQISRSSPIIISDRKIPEKYPNHKENGRMYHGYRKGIYPLPCDEEEQDRLDIFHKLFTVARAEDGLIYAPHPPGSRILDLGCGTGIWSIEVANKFPGSFVVGVDLAPIQPTNTPKNCDFYAPFDFEAPWTMGEDSWDIIHMQMGCGSVASWPSLYRRVFQHLKPGGWFEQVEIDFRPRVEDKDGEPGRAMANWYSTLKHATEATMRPLAHSSNETIRNLQEAGFTEIDHQIVGLPMNPWHPDSHEQKVARWYNLAISESVQPMCLAPFSRVLSWTREQIDRIAFDVKQEAFDKRIKTYNLLHIYQARKPVEE

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
Length
375 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:26566947). Controls the expression of the citric acid, demethylkotanin, orlandin, asperrubrol, tensidol B, atromentin and JBIR8 gene clusters (PubMed:26566947). Represses also the expression of genes related to the production of BMS-192548 and aspernigrin A (PubMed:26566947).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
43.361 kDa
Sequence
MFEISRLLHQPITMASPNRNNYSYQGIESYDSGRSRQNSDAMDIHVITAQEPPREPPDNNDPYDGHGGPAGTSHYSKPPNRWLFYEENGRTYHGYRRGVYPLPCDEQEQDRLDIFHKLFTVARMSESLIYAPHPPNGRFLDLGCGTGIWAIDVAHKYPNAFVAGVDLAPIQPPNHPDNCEFYAPFDFEAPWTLGENSWDLIHLQMGCGSVLGWQNLYKRILRHLQPGAWFEQVEIDFEPRCDDRSLNGLALREWYQYLKQATQDTMRPIAHSSRDTIRHLEEAGFTQIDHQMVGLPLNPWHRDEHEQKVARWYNLAISESIETLSLAPFSRIFHWDLDRIRQITAEVKSQAFNKEIHAYNILHIYQARKPGGPSL

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Emericella nidulans
Length
374 amino acids
Function
Methyltransferase that performs automethylation at Met-207 (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:15075281). Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters (PubMed:15075281). Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development (By similarity). Within the velvet complex, controls light-dependent secondary metabolism (By similarity). Involved in the defense response against Drosophila melanogaster larval grazing (By similarity).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.965 kDa
Sequence
MFEMGPVGTRLPAMTSPAHNHYSYHSPTSSDRGRSRQNSDAMDIQSITEREPATRYAVAGGPAPWNRNGSPSMSPMYSNNSERNQFHEENGRTYHGFRRGMYFLPCDEQEQDRLDIFHKLFTVARVSESLIYAPHPTNGRFLDLGCGTGIWAIEVANKYPDAFVAGVDLAPIQPPNHPKNCEFYAPFDFEAPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRSLDGTALRHWYDCLKQATAETMRPIAHSSRDTIKDLQDAGFTEIDHQIVGLPLNPWHQDEHERKVARWYNLAVSESIENLSLAPFSRVYRWPLERIQQLAADVKSEAFNKEIHAYNILHIYQARKPLR

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
374 amino acids
Function
Methyltransferase that performs automethylation at Met-207 (PubMed:23532849). No other methyl-accepting substrate has been identified yet (PubMed:23532849). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:15075281, PubMed:20132440). Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters (PubMed:15075281, PubMed:16968230). Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development (PubMed:21152013). Within the velvet complex, controls light-dependent secondary metabolism (PubMed:18556559). Involved in the defense response against Drosophila melanogaster larval grazing (PubMed:24023705).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.965 kDa
Sequence
MFEMGPVGTRLPAMTSPAHNHYSYHSPTSSDRGRSRQNSDAMDIQSITEREPATRYAVAGGPAPWNRNGSPSMSPMYSNNSERNQFHEENGRTYHGFRRGMYFLPCDEQEQDRLDIFHKLFTVARVSESLIYAPHPTNGRFLDLGCGTGIWAIEVANKYPDAFVAGVDLAPIQPPNHPKNCEFYAPFDFEAPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRSLDGTALRHWYDCLKQATAETMRPIAHSSRDTIKDLQDAGFTEIDHQIVGLPLNPWHQDEHERKVARWYNLAVSESIENLSLAPFSRVYRWPLERIQQLAADVKSEAFNKEIHAYNILHIYQARKPLR

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Aspergillus fumisynnematus
Length
373 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:26466873). Controls the expression of the cyclopiazonic acid (CPA) gene clusters (PubMed:26466873). Regulates also pigmentation and conidial head morphology (PubMed:26466873).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.548 kDa
Sequence
MFLNGQGGQRPPTVASPPLNVRGSISSDFNALGRSRNNSDAMDIYTITDRGPAAERDPAAGRWHANGSPSINSTSSKNPDRYPCYQENGRTYHGYRKGIYMLPCDEQEQDRLDIFHKLFTVARVSDGLIYAPHPTNGRFLDLGCGTGIWAIDVANKYPEAFVVGVDLAPIQPPNHPRNCDFYAPFDFESLWALGEDSWDLIHMQMGSGSVASWPNLYRRIYSHLRPGAWFEQVEIDFEPRCDDRSLEGLAIRQWYQLLKQATEETMRPVAHNSRETIRNLQEAGFTEIDHQMVGLPLNPWHQDEHERRVARWYNLAISESIETMSLAPFSRVFGWPIERIKQIAADVKSEAFNKEIHTYNILHIYQARKPLAN

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
373 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:15075281, PubMed:17630330, PubMed:19843884, PubMed:24082142, PubMed:24116213). Positively controls expression of 20% to 40% of major classes of secondary metabolite biosynthesis genes such as nonribosomal peptide synthetases, polyketide synthases, and P450 monooxygenases (PubMed:17432932). Controls the expression of the gliotoxin gene cluster (PubMed:15075281, PubMed:17630330, PubMed:19843884). Controls the expression of the fumitremorgin, fumagillin, and pseurotin gene clusters, where genes for fumagillin and pseurotin are physically intertwined in a single supercluster (PubMed:24082142). Regulates the biosynthetic genes required for endocrocin production (PubMed:22492455). Secondary metabolites under the transcriptional regulation of laeA are necessary for inhibition of angiogenesis during invasive infection in mice (PubMed:19843884). Controls the expression of cell surface rodA, a hydrophobin that acts as an antiphagocytic molecule (PubMed:19917717). Regulates also the expression of genes involved in conidial biosynthesis (PubMed:16151250).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.581 kDa
Sequence
MFLNGQGGQRPPMVAFPPLNVRGSISSGFNALGRSRNNSDAMDIYTITDRGPAAERDPAAGRWHANGSPSINSTSSKNPDRYPCYQENGRTYHGYRKGIYMLPCDEQEQDRLDIFHKLFTVARVSDGLIYAPHPTNGRFLDLGCGTGIWAIDVANKYPEAFVVGVDLAPIQPPNHPRNCDFYAPFDFESLWALGEDSWDLIHMQMGSGSVASWPNLYRRIYSHLRPGAWFEQVEIDFEPRCDDRSLEGLAIRQWYQLLKQATEETMRPVAHNSRETIRNLQEAGFTEIDHQMVGLPLNPWHEDEHERRVARWYNLAISESIETMSLAPFSRVFGWPIERIKQIAADVKSEAFNKEIHTYNILHIYQARKPLAN

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Length
369 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Required for aflR expression and subsequent aflatoxin production (PubMed:18667168, PubMed:19411623, PubMed:22289775, PubMed:24040154). Regulates negatively veA expression (PubMed:18667168, PubMed:19411623). Controls conidiophore and conidial development (PubMed:22289775, PubMed:24040154). Required for hydrophobin production which plays a role in cell surface hydrophobicity and host defense escape (PubMed:22289775).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.659 kDa
Sequence
MFGNGQTGQRLPAMASPPHDSYYSQSLASSRSRNNSDAMDIYAITDRDPPAREPSGYSQWYRNGSPSVNSIHSKSSEKQPFYEENGRMYHAYRKGVYMLPCDEQEQDRLDIFHKLFTVARVSDGLMYAPHPRNGRFLDLGCGTGIWAIDVANKYPDAFVVGVDLAPIQPSNHPKNCEFYAPFDFESPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRPLEGLAIRQWYQYLKQATQDAMRPINHNSRDTIRDLQEAGFTDIDHQMVGLPLNPWHQDEHERKVARWYNLAVSESIESLSMAPFSRIFNWDLDRIRRISSEVKSEAFNKEIHAYNILHIYQARKPAN

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Monascus pilosus
Length
367 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23727802). Controls the expression of the monacolin K gene clusters (PubMed:19368389, PubMed:23727802). Regulates also pigmentation (PubMed:23727802).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
42.085 kDa
Sequence
MFGQQQQQQPPPPAASAYLNHNSRWTPPNESAQPRRSSNAMDINAITDRDPAEGHPRSNHTSSSIGSPIDKSPETYPGHEENGRIYHGFRRGIYFLPCDDLEQDRLDIFHKVITVARVSDALIYSPHPRNGRFLDLGCGTGIWAIDVAQKYPDAFVVGVDLSPIQPLNSPRNCDFYAPFDFESPWALGEDSWDLIHMQLGCGSVVSWPSLYRRIFAHLRPGAWFEQVEIDFEPRCDDRSLEGLALHHWYQCLKQATEEAMRPLAHNPRETIRHLQEAGFTEIDHQIVGLPLNPWHQDEHEKTVARWYNLAICESIETFSLAPFTRFFGWPVDRIKRLVADVRSEAFNKDIHAYNILHIYQARKPISN

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)
Length
316 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23106229). Controls the biosynthetic gene cluster for beauvericin, a depsipeptide mycotoxin that functions as a virulence determinant (PubMed:23106229). The velvet complex regulates also chromatin structure and transcription of siderophore biosynthetic genes and is required for infection of tomato plants (PubMed:23106229). The velvet complex also governs expression of nitrate metabolism genes (PubMed:24240057).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
36.726 kDa
Sequence
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRPSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLTDCDLIHMRMLLGSIQTDLWPQVYHNVFEHLTPGIGFFEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVTPQEHRQMLEAAGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ

Gene
laeA
Protein
Secondary metabolism regulator laeA
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
316 amino acids
Function
Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23874628). Controls the expression of the mycotoxins trichothecenes and zearalenon gene clusters (PubMed:23874628). Negatively controls perithecial induction, but positively controls virulence toward the host plant (PubMed:23874628).
Similarity
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Mass
36.78 kDa
Sequence
MAVMPPPNSVNGSERRYLEDGIWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFQAPIQRKAPRMMDIGTGTGIWPINVAEECFTDAQIMAVDLNQILPALIPPGVLPKQYDIEEPTWDSLYTDCDFIHMRMLLGSIQTDLWPQVYRNIFEHLAPGIGHLEHIEVDWTPRCDDDERPANSAFEKWAELFFDGMDRFNRIARVVPQETRQLLEATGFTDVKQEMIRAYVCPWSSDRQEREIARWFNIGLSHSLESLSLKPLVEKLGWKPEDVRKLCTTAKRETCVLRFHTYCNIYVWTARKPGPPQ