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kshB

Gene
kshB
Protein
3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
353 amino acids
Function
Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.
Mass
37.562 kDa
Sequence
MTDEPLGSHVLELQVAEVVEETSDARSLVFTVPEGAEIAADRLRYSPGQFLTLRVPSDRTGSVARCYSLSSSPTTDDRLTVTVKRTADGYASNWLCDNAHAGMRIHVLAPSGTFVPKDLDTDFLLLAAGSGITPMMAICKSALAEGTGNVVLIYANRDENSVIFAGALRELAAKYPDRLTVVHWLETVQGLPTAAGLGALAKPFAGREAFICGPGPFMTAAEDALRAAGTPDDHIHIEVFKSLESDPFAAVVIPEDDGDDQGPATAVVTLDGTTHEIRWPRSAKLLDVLLDKGLDAPFSCREGHCGACAVLKKSGEVHMEINDVLEPSDLEEGLILGCQATPVSDSVEVTYDE

Gene
kshB
Protein
3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
Organism
Rhodococcus rhodochrous
Length
351 amino acids
Function
Probably involved in the degradation of cholesterol. In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 19-nor-4-androstene-3,17-dione (nordion), 1-(5alpha)-androstene-3,17-dione, 5alpha-androstane-3,17-dione and 5beta-androstane-3,17-dione. KSH has the highest activity with 3-keto-Delta4 steroid substrates.
Mass
37.887 kDa
Sequence
MTTVEVPHGSRSVILTVSAVVEETADTRSIVFAVPDELRDKFAYRPGQFLTLRIPSDRTGSVARCYSLASSPFTDDAPKVTVKRTSDGYGSNWLCDNIATGQTLEVLPPAGVFTPKSLDHDFLLFGAGSGITPVISILKSALTQGGGKVVLVYANRDEKSVIFAEELRALAEKYPTRLTVVHWLESVQGLPTADQLAAIAAPYESYEAFMCGPGPFMDTVHQALNTVGMPRARVHAEVFNSLSGDPFADQAPVEVSDEDAADAATVEVELDGEVHKLSWPRKQTLVDIMLAKGIDVPYSCQEGECGSCACTVLEGKVEMENCDVLDPEDIEAGYILGCQARPVTDHLKIEF