knl-1

Kinetochore null protein 1

1010 amino acids

Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division (PubMed:14522947, PubMed:15371340, PubMed:17129783, PubMed:18070910). Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy (PubMed:15767665, PubMed:16273096). Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (PubMed:19109417, PubMed:20729837, PubMed:24567362).

113.231 kDa

MSMEPRKKRNSILKVRQAVETIEETVMNSGPSSTTTNRRVSFHNVKHVKQYDRDHGKILDATPVKEKITDTIGSDGILTPRGGNMDISESPACTSSFQVFGGGNLDKTMDMSLETTINENNETARLFETTRDPTLLYEKIVETTTKVTERIVSMPLDDTLAMFNTTNQEDKDMSVDRSVLFTIPKVPKHNATMNRTIPMDLDESKAAGGQCDETMNVFNFTNLEAAEMDTSKLDENNTMNAIRIPINSNVMPVDMDITEHHTLIEEKKNDTFGPSQLMDISAPQVQVNDTLAIFNSPRDICNKGLGVPQNLINIASNVVPVDMDITDQAVLNAEKKNDQFETSQLMDISIPKVLVNDTMAMFNSPKHVSKSSMDLEKTIEAADKSTKYPSIADEVEDLDMDMDITEQQPCEAGNQQNDGLQLQKEDLMDISVIRDSPAVNDTMAVFQSPARVKIGANNSIIDSQKSIVFGDEMSIDETQNDGTLTLPKSNVEVTTTNDVYTSLERQEENASENVSMINESSVHSEIDKKSFMLIEEERAFMHSSMIDVAQKLEDDGSSKTPVILASQSASLATKEPSALHNSSATLNNSMELDNNTLLKTMQITTCEDISMVHESIAVELNSNKEQEQFGDETLQKNDTSNTGANFTFQGHNETSQIMNNVDSEAVNTSKISTYSAFNLSINQSISKRRRSLLNSARESPRRVALENSIMSMNGQTMEALTEYRQNKTMQTSQDSMPSMSLNDSGRDILAMNTSVRSPHLNSSKTAAPGTPSLMSQNVQLPPPSPQFEMPDFDPAVVNVVYLTSEDPSTEQHPEALKFQRIVENEKMKVQHEIDSLNSTNQLSAEKIDMLKTKELLKFSHDEREAIMIARKDAEIKFLELRLKFALEKKIESDQEIAELEQGNSKMAEQLRGLDKMAVVQKELEKLRSLPPSREESGKIRKEWMEMKQWEFDQKMKALRNVRSNMIALRSEKNALEMKVAEEHEKFAQRNDLKKSRMLVFSKAVKKIVNF

knl-1

Kinetochore null protein 1

957 amino acids

Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1. Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (By similarity).

105.839 kDa

MDNQRKKRNSILKVRQETNLMDVLEDTTVATSSGATNRRVSFHQLKQVKNYDRAGGQIIDATPIKEKAYDTMSSDGNSTSHTTRLDMDITGLNSTPVTPKTQTPFNGSMDMSVENYDETARLFDITRDKTICVYEKTVETTTTKVVERVVRVPEGSSGANNDTLALFNMTDRAEVDMSVDGGSEGALKVDDTISVFNQTNVEPVDMDITVQKPLDDTMGVFRSPAIPTSSRIQKTSASTMDSQNMSMSMDMDITSNEMMAAFKSPKIMSSVLVAAVKDSDDMDLTGLVNTAAEDVADDTMAVFRTPTRAQTTIQKTSGEIPESVDMEMTGIGNSDAPDDTMAVFRTPTRAQQTVQKTSGEIPESVDMEMTLLALLQPVSDVKDNFDDVAMDITQQTLVGVSDDTMAVFKNPAAEKKTPGKPLFDESMEIESTIVCPDNVTFSETAQPENPAYHSSMLMSMASEVSEDVVVQKTSESLQQSSMRMSTTITEDVTASKNPESSTISEVQKIPEVVQKTSNGVEDIQNASETPEDVSMEITSEVVEGERGTMYQMSTMDVDSLQKTSLASPKIQMTSFTDTSEKMGGVSETSLIQTMMIEASESMECSEAPEDVTASPEGLTMAPEDVTVASNVSGIVSVSSISRRRRSQLQESLHRESPRRMALEKNLSMMSQMGGASEALAEFRQNKLKNQTTLLNDSVNTTIGANTSESIGRDIFKMNTSIRSPAHRSSTAPSPMVSKTLPESPKFHVTPFDAAIVNVIYLTPEDAETQEPIPEAFEFEKVLSAEESNVHKEIDTANWSISGAIKSNLDAEVMNIARGQAEMKFLELRGKFAKESNVEIAQKIQELESQNLELAGKIRDSQNLRVLQKQIEELQKPQFSLEEAERIENEYHETKVELLRAQAASIRRQHELLMTIREERRRLIHEIEEKDELLARLEEEDRKKKEEMVERVRGVMRA