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kdm8

Gene
kdm8
Protein
Lysine-specific demethylase 8
Organism
Xenopus tropicalis
Length
443 amino acids
Function
Histone demethylase required for G2/M phase cell cycle progression (By similarity). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Mass
50.251 kDa
Sequence
MHRSVPEQVSAELPATLEQFQITLGADVEDRVEECVREAARCLYRGAIVQCGALGELLIDYSWEKLNARNWREVGREWRAVYSYGCLFRAVGLCSVTGSIEEALQVCDIGLLMGAEIMDNLLGRIISVLQRIAPSREETKLEAERGVREPGLESSKLHSPGEHSNKKSFASVTGRKRIREGPEADFDPKGCSISEKVPCLLVPVLDSETAIPKLHCPSLEHFRDHYLVPQKPVVLEGVIDHWPCLKKWSVEYIQRVAGCRTVPVELGSRYTDAEWSQRLMTVNEFITKYILDKQNGIGYLAQHQLFEQIPELKEDICIPDYCCLGEASEDEITINAWFGPAGTVSPLHQDPQQNFLAQIVGRKYIRVYSVAETEKLYPFDSSILHNTSQVDVESPDQNKFPRFSQASYQECILSPGQVLFIPVKWWHYIRALDLSFSVSFWWS

Gene
KDM8
Protein
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Organism
Homo sapiens
Length
416 amino acids
Function
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).
Mass
47.27 kDa
Sequence
MAGDTHCPAEPLAREGTLWEALRALLPHSKEDLKLDLGEKVERSVVTLLQRATELFYEGRRDECLQSSEVILDYSWEKLNTGTWQDVDKDWRRVYAIGCLLKALCLCQAPEDANTVAAALRVCDMGLLMGAAILGDILLKVAAILQTHLPGKRPARGSLPEQPCTKKARADHGLIPDVKLEKTVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQKWSLEYIQEIAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFDQIPELKQDISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRKYIRLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAPFLSCILSPGEILFIPVKYWHYVRALDLSFSVSFWWS

Gene
Kdm8
Protein
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Organism
Mus musculus
Length
414 amino acids
Function
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (PubMed:30500822). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).
Mass
47.145 kDa
Sequence
MSEDTTEPLVGSSTLWKELRTLLPDKEEELKLDLGEKVDRSVAALLRQAVGLFYAGHWQGCLQASEAVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKALCLCQAPQKATTVVEALRVCDMGLLMGAAILEDILLKVVAVLQTHQLPGKQPARGPHQDQPATKKAKCDASPAPDVMLERMVPRLRCPPLQYFKQHFLVPGRPVILEGVADHWPCMKKWSLQYIQEIAGCRTVPVEVGSRYTDEDWSQTLMTVDEFIQKFILSEAKDVGYLAQHQLFDQIPELKRDISIPDYCCLGNGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWWS

Gene
Kdm8
Protein
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Organism
Rattus norvegicus
Length
414 amino acids
Function
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity).
Mass
47.247 kDa
Sequence
MSEDTTEPLVGPSTLWKDLRALLPDTEEELKLDLSEKVDRSMATLLRQALGLFYEGRWQKCLQASEAVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKTLCLCQAPQKATAVAEALRVCDMGLLMGAAILGDILLKVATVLQTHLLPRKQPACGPHQDQPATKKAKHDASSTPDVVLDREVPRLRCPPLQHFKKHFLVPGRPVILEGVADHWPCMKKWSLQYIQEIAGCRTVPVEVGSRYTDEDWSQTLMTVNEFIHKYILSEAKDVGYLAQHQLFDQIPELKQDISIPDYCCLGNGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWWS

Gene
kdm8
Protein
Lysine-specific demethylase 8
Organism
Danio rerio
Length
406 amino acids
Function
Histone demethylase required for G2/M phase cell cycle progression (By similarity). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Mass
46.752 kDa
Sequence
MASVWTDIRAVLPSTVSEFPLDFSEKIDLSVLKCLELSRDQLYSEADCPVSAERAQIIIDYSWEKLNIGTWRDVDKEWRRVYSYGCLFKVLSLCHGNPPQNIIQEAVRTCDMSLLMGAAIMDNILQRLVGILRNKIKTTCPNKAERSEEPFSKKRKHDCKSEPVLNPTKEVPRIHCPSLERFRSDFLDPKKPVIIEGITDLWPAFTQHPWSIDYLRTVAGCRTVPIEVGSKYTDEEWSQKLITVNDFIDRYITGTEEDGVGYLAQHQLFDQVPELKEDIRIPDYCCLGEGDEDDITINAWFGPGGTVSPLHQDPQQNFLAQVVGRKYIRLYSPEDTKSLYPHESQLLHNTSQVEVENPDLVKFPDFSRASYEECVLCPGDVLFIPLQHWYYVRSLELSFSVSFWWS

Gene
KDM8
Protein
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Organism
Bos taurus
Length
406 amino acids
Function
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity).
Mass
45.907 kDa
Sequence
MAGPSTLWETLQALLPHTKEELKLELGEKVEGSVLMLLQEAAELFLGGQRRECLQTCEVLLDYSWEKLNTGPWQHVDKDWRRVYAFGCLLKAVCLCEPPGDAASVAAALKACDMGLLMGAAILGDILLKVAAVLQKYLLSGKRPAPGPSQEPPGTKKARNDHVPIPDVTTERTVPRLHCPSLQYFKKHFLVPGRPVILEGVANHWPCMKKWSLEYIQEVAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIREEPKDIGYLAQHQLFDQIPELKQDISIPDYCCLGDGEEEEITINAWFGPQGTVSPLHQDPQQNFLAQVMGRKYIRLYSPQESEALYPHDTHLLHNTSQVDVENPDLEKFPRFAEAPFLSCVLSPGEVLFIPVKHWHYVRALDLSFSVSFWWS

Gene
kdm8
Protein
Lysine-specific demethylase 8
Organism
Salmo salar
Length
404 amino acids
Function
Histone demethylase required for G2/M phase cell cycle progression (By similarity). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Mass
46.254 kDa
Sequence
MAELWSAISAALPVTEAEFPLDFSEKVEPSVVDVLKRCRQQLYTGSGRWRQNAQIILDFSWEKLNTGTWRDVDKEWRCLYSYGCLFKVAALCRDDASPATVQEAIRTCDLGLLMGAAIMDNILQTFVKILQNEIRKRHSNEENLSEGVSAKKMKVDCVSVPVVKQALAVPRIHCPSLESFKKDYLDPQKPVILEGIIDHWPAFKNHPWSIEYLQTVAGCRTVPVEVGSRYTDEEWSQTLLTVNEFIDRYIVVKDASSLGYLAQHQLFDQVPELKDDIRIPDYCCLGEGEEDDITINAWFGPGGTVSPLHQDPQQNFLAQVVGRKYIRLYSPEDTEKLYPHQLQLLHNTSQVEVESPDVVRFPEFVKAPYLECVLQPGEVLFIPVKHWHYVRSLELSFSVSFWWS