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kamB

Gene
kamB
Protein
16S rRNA (adenine(1408)-N(1))-methyltransferase
Organism
Streptoalloteichus hindustanus
Length
215 amino acids
Function
Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Kanamycin-apramycin resistance family.
Mass
23.67 kDa
Sequence
MRRVVGKRVLEFSEAEFDQLRSQYDEVVLDVGTGDGKHPYKVARQHPNQLVVALDADKTRMERMSAKAAAKPAKGGLPNLLYLWATAEKLPPLTGVGELHVLMPWGSLLRGILGSSPEMLRGLAAVCRPDAAFLVALNLHAWRPPVPEVGEHPEPTPETVDEGLAARYAQAGWQLTDCRYLAAEEVAALETSWTRRLNSSRDRFDVLALTGKINP

Gene
kamB
Protein
16S rRNA (adenine(1408)-N(1))-methyltransferase
Organism
Streptoalloteichus tenebrarius (strain ATCC 17920 / DSM 40477 / NCIB 11028)
Length
215 amino acids
Function
Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides, including kanamycin, neomycin and apramycin.
Similarity
Belongs to the methyltransferase superfamily. Kanamycin-apramycin resistance family.
Mass
23.664 kDa
Sequence
MRRVVGKRVQEFSDAEFEQLRSQYDDVVLDVGTGDGKHPYKVARQNPSRLVVALDADKSRMEKISAKAAAKPAKGGLPNLLYLWATAERLPPLSGVGELHVLMPWGSLLRGVLGSSPEMLRGMAAVCRPGASFLVALNLHAWRPSVPEVGEHPEPTPDSADEWLAPRYAEAGWKLADCRYLEPEEVAGLETSWTRRLHSSRDRFDVLALTGTISP