About Products Protein Database Contact

jmjd-2

Gene
jmjd-2
Protein
Lysine-specific demethylase 4
Organism
Caenorhabditis elegans
Length
922 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:24685137). Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion (PubMed:22212395).
Similarity
Belongs to the JHDM3 histone demethylase family.
Mass
105.659 kDa
Sequence
MASAATTTHFPSSRIPSEPCASSGPLFPDDVLFTTEASSASSSSCHVENDSRPLSPTMFTDGRTPVNISAKHLKDHPLHEPTGTSEVLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEITQPARETIEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHGEPIYGADTEGSFYDAQVEEWNMNRLGTILEDTNYEIKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFLHFGAPKYWFAISSEHADRFERFMSQQFSYQNEYAPQCKAFLRHKTYLVTPELLRQAGIPYATMVQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDCNKDSVKIDMTHFMAKYRPDEYTTWWTYWYGGGRELWIPKKKKEVPKKRRQSLADASKIAKRARLGASSTATDSDGSSGSSGSEEATEGSSFMRALPAGYTVHNWQLRPDYDELLRKYKKETKLLRSDTRIDFYQEREFNHARRAEWPHCAVCQYFQPPHMNAINHTVPNSSRRLIPKWCFSKTDTKKHEDHHEPPPPLDRLLTCSNCHVTVHSHCCSGGGGGGGDDDDVTSSGEPWRCPRCRNRTDVEIRTTSCQLCELRGGALIPCQIGTDSTWAHVACALFNRRAIFDCPNRPGACFVEPSPRQQSETPRMPPRRLSEEYRAELGDLYENSRWECVVCHRTDEGLAPCVLCIEEQATTSLPTLAHVTCARRVGFVCEVRDYPRGVVMICHKHEHSYLVNKTTQQQAYTNVKVGDFVFVEDVVEPPQKLFTRGAIVRADKKETVVVDFLDNSCSRDNHVEDIISCECLFCENGDHQYGARVKVVWDDKQVYDAYFRGKGQMIEYTVRLEDGREVRHPRNRLKTKRELNAYLKK