About Products Protein Database Contact

itpa

Gene
ITPA
Protein
Inosine triphosphate pyrophosphatase
Organism
Bos taurus
Length
208 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
23.061 kDa
Sequence
MAASLAGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIRKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLEGFQDKSAYALCTFAFSTGDPNEPVRLFRGRTMGRIVVPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALLALQEYFSSLTPGVGDDHPSWGSGEG

Gene
itpa
Protein
Inosine triphosphate pyrophosphatase
Organism
Danio rerio
Length
203 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
22.869 kDa
Sequence
MAVPTGRALVFVTGNAKKLEEVVQILGDKFPYKLISKKIDLPEYQGEPDDISIQKCKEAARQVDGPVLVEDTCLCFRALEGLPGPYIKWFLDKLKPEGLYKMLAGFEDKSAWALCTFAFCAGKEEPVQLFRGITEGHIVEPRGPRDFGWDPCFQPEGYDKTYAELPKEVKNSISHRYRALAALSEHFCQDNGAPETKRSKHQD

Gene
ITPA
Protein
Inosine triphosphate pyrophosphatase
Organism
Gallus gallus
Length
201 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
22.262 kDa
Sequence
MAAPVRRSVVFVTGNAKKLEEVTQILGDSSPYTLVARKIDLPEYQGEPDEISVQKCREAARQIRGPVIVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLYKLLAGFEDKSAYALCTFAFSTGNPEEPVKLFKGQTHGVIVEPRGPRDFGWDPCFQPDGYDQTYAELPKAVKNSISHRYRALSELSAFFLQSNPTEAPSSPS

Gene
Itpa
Protein
Inosine triphosphate pyrophosphatase
Organism
Mus musculus
Length
198 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.897 kDa
Sequence
MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Gene
Itpa
Protein
Inosine triphosphate pyrophosphatase
Organism
Rattus norvegicus
Length
198 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.927 kDa
Sequence
MAASLVGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLYQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGKTPGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALFKLQEYFGVTDGAGDH

Gene
itpa
Protein
Inosine triphosphate pyrophosphatase
Organism
Xenopus laevis
Length
195 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.803 kDa
Sequence
MAAAAGRSIVFVTGNAKKLEEVVQILGDKFPCKLVAKKIDLPEYQGEPDEISIQKCREAAKQIQGPVIVEDTCLCFNALGGLPGPYIKWFLEKIKPEGLHRMLEGFEDKSAIALCTFAYCNGNPDDTVLLFRGKTLGQIVLPRGPRDFGWDPCFQPDGFQQTYAELPKEVKNTISHRYRALKEMSDYFIQNGTKV

Gene
itpa
Protein
Inosine triphosphate pyrophosphatase
Organism
Dictyostelium discoideum
Length
194 amino acids
Function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.73 kDa
Sequence
MSISKKIVFVTGNAKKLEEALQILGTSFPIESKKVDLPELQGDPIDISIEKCKIAAREVGGPVLVEDTCLCFNALKGLPGPYVKWFLDKLEPEGLYKLLDAWEDKSAYALCNFAFSEGPDSEPIVFAGKTDGIIVQPRGPRNFGWDPVFQPDGYKETYAEMDKSIKNTISHRTRSLQKVKEFLKSKGYENCKFE

Gene
ITPA
Protein
Inosine triphosphate pyrophosphatase
Organism
Homo sapiens
Length
194 amino acids
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.446 kDa
Sequence
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA