Protein
Bifunctional enzyme IspD/IspF
Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Function
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
Similarity
In the C-terminal section; belongs to the IspF family.
Sequence
MACAVLIVAAGRGTRAGGAVPKQYHRLGGESVLRRTLLRFAECAAIDVIQVVTHPDDAPLYEQAVAGLTKVLPQVAGGATRQQSVRAGLEALAAYGPERVLVQDGARPFTPPEVIARAIAALDGNTAAIPVLPVTDTIKHVDAAGHVTGTVDRAMLRAVQTPQAFRFAELLAAHRAAADARVADLTDDASVMEWAGHTVATFAGDSENVKLTSAEDLARAARMLADLPDVRTGTGFDVHAFGPGDHVMLGGVAIPFDRGLDGHSDADVGLHALTDAVLGALADGDIGAHFPPSDPQWKGATSDRFLAFAIERVRERGGIVAHLDLTLICEAPKVGPHRDAIRAEIARICDLPLGRVSVKATTTEKLGFTGRREGIAAMASATIRLPLEIGA