irx4-a

Iroquois-class homeodomain protein irx-4-A

496 amino acids

Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development.

Belongs to the TALE/IRO homeobox family.

55.524 kDa

MSYPQFGYPYSSTPQFLMTTNSLSTCCESSGRSLSDSAAAASAQTPVYCPVYESRLLATARHELNSAAALGVYGNPYTSTQGYGNYVTYGADASAFYSLNAFESKDGTGSAHAGIPQTAAYYPYEHTLSQYQYDRYGTMDGSSRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRPYDEEEEEEEEEEDSQKATIKNEKKTVDEEVVREDKALDLSDLEDFDTIESESSECELKQPFHHQPQDGHQLRQRDCVNDHCKDVILKMPLNSTVNQELDRTNICLKSGVDQCEQDVLRGRQRSGESKACFQQQQILDSKPRIWSLAHTATSLNQTEYPSCMLKHQGLSSPSSSSSSSAVSTPVCVIDRRQDSPVTSLRNWVDGVFHDPLFRHSTLNQALTNTTVSWATTKGTLIDSGSLGRSVGNPTNVKGQLPNIPHDTNKEFIAFQKSGSKMFCS