About Products Protein Database Contact

ileS1

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Burkholderia mallei (strain ATCC 23344)
Length
945 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
105.68 kDa
Sequence
MSNKKADSKPQAKYPVNLLDTPFPMRGDLPKREPQWVEDWEARGVYEKIRAASQGRPKFILHDGPPYANGDIHLGHAVNKILKDMVVKSRNMAGFDAPYVPGWDCHGMPIEIQIEKRFGKSLPAAEVMAKARAYATEQIEKQKVGFKRLGVLGEWGNPYKTMNFQNEAEEIRALGKIIEKGYVYRGLKPVNWCFDCGSALAEAEVEYKDRTDPTIDVLFAFAEPEKTAHAFGLAELPRAEGGIVIWTTTPWTIPANQALNLHPEIVYALVDTERGLLVMAEERVEACMKDFGLTGRVIARTPGEKLANLRFHHPLAAAHPGYKRTSPVYLGDYVTTDTGTGVVHSSPAYGVEDFTSCKAHGMTDSDIINPVMGDGRYIESLPLFGGLTIWDANPKIVDALKAAGSLLRNERYAHSYMHCWRHKTPIIYRATSQWFAGMDTQPAGGGKTLRETALDAVDATAFYPSWGKQRLHAMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAKRVERQGIEAWQTLDARELIGDDANLYEKNRDTLDVWFDSGTTHWHVLRGSHKDQLQFPADLYLEGSDQHRGWFHSSLLTASMLDGRAPYKGLLTHGFTVDGEGRKMSKSLGNGIDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDYAKDALPAGQWLEIDRYAVAFAAQLQAELLAHYEKYEFHPVVAKLQTFCSEDLGGFYLDVLKDRLYTSAPASPARRSAQTALYHVTQGLLRVLAPFLSFTAEEAWRVFQPQSDTIFTETYYAYPEIAGAEALIAKWTLLRDVRGDVTKALEEARTANRIGSSLQAQVEVRASGARYDALASLGDDLKFVLITSAATVVKVDAQGDESVDVAASTYPKCERCWHYREDVGAHADHPTLCGRCFSNLFENGETRSAA

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Burkholderia pseudomallei (strain K96243)
Length
945 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
105.71 kDa
Sequence
MSNKKADSKPQAKYPVNLLDTPFPMRGDLPKREPQWVEDWEARGVYEKIRAASQGRPKFILHDGPPYANGDIHLGHAVNKILKDMVVKSRNMAGFDAPYVPGWDCHGMPIEIQIEKQFGKSLPAAEVMAKARAYATEQIEKQKVGFKRLGVLGEWGNPYKTMNFQNEAEEIRALGKIIEKGYVYRGLKPVNWCFDCGSALAEAEVEYKDRTDPTIDVLFAFAEPEKTAHAFGLAELPRAEGGIVIWTTTPWTIPANQALNLHPEIVYALVDTERGLLVMAEERVEACMKDFGLTGRVIARTPGEKLANLRFHHPLAAAHPGYKRTSPVYLGDYVTTDTGTGVVHSSPAYGVEDFTSCKAHGMTDSDIINPVMGDGRYIESLPLFGGLTIWDANPKIVDALKAAGSLLRNERYAHSYMHCWRHKTPIIYRATSQWFAGMDTQPADGGKTLRETALDAVDATAFYPSWGKQRLHAMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAKRVERQGIEAWQTLDARELIGDDANLYEKNRDTLDVWFDSGTTHWHVLRGSHKDQLQFPADLYLEGSDQHRGWFHSSLLTASMLDGRAPYKGLLTHGFTVDGEGRKMSKSLGNGIDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDYAKDALPAGQWLEIDRYAVAFAAQLQAELLAHYEKYEFHPVVAKLQTFCSEDLGGFYLDVLKDRLYTSAPASPARRSAQTALYHVTQGLLRVLAPFLSFTAEEAWRVFQPQSDTIFTETYYAYPEIAGAEALIAKWTLLRDVRGDVTKALEEARTANRIGSSLQAQVEVRASGARYDALASLGDDLKFVLITSAATVVKVDAQGDESVDVAASTYPKCERCWHYREDVGAHADHPTLCGRCFSNLFENGETRSAA

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Pseudomonas fluorescens
Length
943 amino acids
Function
Confers resistance to the antibiotic mupirocin (pseudomonic acid A), an Ile-analog produced by P.fluorescens NCIMB 10586 itself that competitively inhibits activation by Ile-tRNA synthetase, thus inhibiting protein biosynthesis.
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
105.719 kDa
Sequence
MTDYKATLNLPDTAFPMKAGLPQREPQILQRWNSIGLYGKLREIGKDRPKFVLHDGPPYANGTIHIGHALNKILKDMILRSKTLSGFDAPYVPGWDCHGLPIEHKVEVTYGKNLGADKTRELCRAYATEQIEGQKSEFIRLGVLGEWDNPYKTMNFKNEAGEIRALAEIVKGGFVFKGLKPVNWCFDCGSALAEAEVEYEDKKSSTIDVAFPIADDAKLAEAFGLASLAKPAAIVIWTTTPWTIPANQALNVHPEFTYALVDVGDRLLVLAEEMVESCLARYELQGSVIATATGSALELINFRHPFYDRLSPVYLADYVELGSGTGIVHCSPAYGVDDFVICKKYGMVNDDIINPVQSNGVYVPSLEFFGGQFIFKADQPIIEKLREVGALMQTAAIQHSYMHCWRHKTPLIYRATAQWFIGMDKEPTSGDTLRVRSLKAIEDTKFVPSWGQARLHSMIANRPDWCISRQRNWGVPIPFFLNKESGELHPRTVELMEVVAQRVEQQGIEAWFKLDAAELLGDEAPLYDKISDTLDVWFDSGTTHWHVLRGSHPMGHETGPRADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRELLTHGFTVDETGRKMSKSLKNVIEPKKINDTLGADIMRLWVASTDYSGEIAVSDQILARSADAYRRIRNTARFMLSNLTGFNPASDLLPAEDMLALDRWAVDRTLLLQRELQEHYGEYRFWNVYSKIHNFCVQELGGFYLDIIKDRQYTTGANSKARRSAQTALYHISEALVRWIAPILAFTADELWEYLPGERNESVMLNTWYEGLTELPADFELGREYWEGVMAVKVAVNKELEVQRAAKAVGGNLQAEVTLFAEDGLTADLAKLSNELRFVLITSTASLAPFTQAPADAVATEVPGLKLKVVKSAFPKCARCWHCREDVGVNPEHPEICGRCVDNISGEGEVRHYA

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Bacillus anthracis
Length
921 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.611 kDa
Sequence
MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Length
921 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.59 kDa
Sequence
MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDGAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Length
921 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.562 kDa
Sequence
MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYSIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVLEEREDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESISEDLKQLFIVSEYKLGGMMDEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Bacillus cereus (strain ZK / E33L)
Length
921 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.621 kDa
Sequence
MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHQGSPNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDGAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Length
921 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.634 kDa
Sequence
MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPKYEHTAVVVAQATGETCERCWVVSETIGKDAEHETLCERCATVVKENYVK

Gene
ileS1
Protein
Isoleucine--tRNA ligase 1
Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Length
918 amino acids
Function
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Mass
104.887 kDa
Sequence
MDYKQTLLMPKTAFPMRGNLPNKEPERQKKWEETNQYAKTLERTKGRPLFVLHDGPPYANGDIHIGHALNKVLKDFIVRYKSMTGYHAPYIPGWDTHGLPIETALTKKKKIKRKEMDIAAFRKLCEEYALGQINNQREQFKQLGVRGDWDNPYITLTKDYEASQIKVFGDMARKGYIYKGLKPVYWSPSSESALAEAEIEYQDKRSPSIYVAFEVKGGQALLSGGEKFIIWTTTPWTLPANLGISLHADLTYIVVQVGEEKYIIAEALFDDVSESLGWENPQVLQSFKGKEAEGIEAQHPFYDRTSLVMLGEHVTTDAGTGCVHTAPGHGEDDFYVSRSYGIDAFCPVDEKGVFTQEAPGFEGLFYDEANKIITEKLDASGALLKLEFITHSYPHDWRTKKPTIFRATSQWFASIKDFRVDILEEIKQVNWYPHWGETRLYNMVRDREDWCISRQRAWGVPIPVFYGEDGTPIITDETINHVSELFREHGSNIWFEKEAKELLPEGFTSEHSPNGNFAKETDIMDVWFDSGSSHEGVLLNRQNHQRPANVYLEGSDQYRGWFNSSLSTSVAVTGKAPYKAVISHGFVLDGNGRKMSKSLGNVIVPSKVQKQLGSDILRLWVSSVDYQADVRISDDILKQTSESYRKIRNTFRFLLANLADFNPNTDRVKEENMEEVDRYMVHRLQNVLAEAHKNYNQYEFAPVFQQIHHFCSVDLSSFYLDFAKDILYIEAKDHPRRRSIQTGYYEVLTSLVKLIAPIIPHTAEEVWEYIPEPEAESVHLTDIPEARDVAINEQTVDKWNHFMKIRDDVLKALEEARSEKVIGKSLEAKISIAAKDEGTKKVLDEMEHLHQYFIVSEAVIVDTLTDAKEGNVVNVQVEVHPGETCDRCWVSSETVGENKNHPSLCSRCADVVTKHYAD