Protein
Ceramide synthase hyl-2
Organism
Caenorhabditis elegans
Function
Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2.
Similarity
Belongs to the sphingosine N-acyltransferase family.
Sequence
MPWWTDALYWLPRGVSWSDMYNKTTEPGYMYPHYSHLWMTVLTGISLIIYRFVFENYIFVPLAHFLSRKNPPETRRGTLDREKKYSRMAECAMRALYYTISFVCGLYLVLHESHLYDITECWRNWPFHPIPNAVAWYYWIQGGFYIALVFGILFLDAKRSDFWQMLVHHFITLALIGVSWTMNMVRVGTLILVSHDAVDILIDVGKILRYEQFETALTICFAGVLFVWVATRLVYYPFWIIRSVWFDAPALIQDDYEWLNFDQQPQAPRFIMLLLTALLILHIFWAYILFKIAYDTIQEGVVDDVREDFDEQSLVNREKAKQQNKNKDD