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htr1aa

Gene
htr1aa
Protein
5-hydroxytryptamine receptor 1A-alpha
Organism
Takifugu rubripes
Length
423 amino acids
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily.
Mass
47.001 kDa
Sequence
MDLRATSSNDSNATSGYSDTAAVDWDEGENATGSGSLPDPELSYQIITSLFLGALILCSIFGNSCVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQDICDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISVTWLIGFSISIPPMLGWRSAEDRANPDACIISQDPGYTIYSTFGAFYIPLILMLVLYGRIFKAARFRIRKTVKKTEKAKASDMCLTLSPAVFHKRANGDAVSAEWKRGYKFKPSSPCANGAVRHGEEMESLEIIEVNSNSKTHLPLPNTPQSSSHENINEKTTGTRRKIALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCAENCYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAFKKILRCKFHRH