Function
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
Sequence
MFKSLYTRIAIYTITVMIFSAVASFLCTNIIYHNYLKENNDAKIMRTLKDSIQYQKESRIEASAPFFKHLGEMNYQVMTISEDGHRTYYGTEFRKDNISKKTAESVLHGKDYHGIKNLPYNPIITGFFENTTKNTVGIAYQSKGHTYAVFMRPDIGKTFSEFRIFLAILITLLLLFSIILVISSTYAIIKPIQQLKRATERLMHGNFDEVIHVTRKDEFGTLQYRFDKMRLSLKQLDDMRQHFVQNVSHEIKTPLTHIHHLLDLLKFAKTDNAREQYIEEIYEVTTQLSELTKALLLLSEIDNGAHLDFDDDIQLNQLIKKIIRHEQFSANEKDLIIMSDLETISMNGNERLLHQAFQNLITNAIKYSTTGGMVDVTLSQNLETITCTITDDGQGMSAETQARIFERFYKSSNHDNSNGLGLAIAKAIFELHHGTITVDSEKNAGTTFTITFKKVPKTIS