hrpA

ATP-dependent RNA helicase HrpA homolog

1304 amino acids

Belongs to the DEAD box helicase family. DEAH subfamily.

149.626 kDa

MKNSSVKHTLTPLQQSLFSQLNDIMLVDQRRLSARIHGIGKIKSQEAQQAVAAEIQQQIEQARLRVEQRKSAVQNPIVFPESLPVSQRKVEIQKLISEHQVIVVAGETGSGKTTQLPKMCLELGFGNLGMIGHTQPRRIAARSVAARIAEELETELGGLVGYKVRFNDQISDNTQIKLMTDGILLAEIQNDRFLNQYSCLIIDEAHERSLNNDFILGYLKQLLPRRRRDLKLIITSATIDVERFSKHFNNAPIIEVSGRTYPVEVRYRPVVEEDDQDQLQGILNAVDELQAEGRGDILIFMNGEREIRDTAEALQKQNLKHTEILPLFARLSAQEQNKIFHPSGLNRIVLATNVAETSLTVPSIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMTALGLDDIEAFPFVDAPDERHIQDGVKLLEELGAFETVQTKSGEKRLLTRVGRQLAQLPVDPRLAKMILSAVNFGCVYEMMIIVSALSIQDPRERPQEKQQASDEKHRRFADKKSDFLAFLNLWRYLQEQQKESSKNQFRRQCQKDFLNYLRIREWQDIYHQIRLTVREMSLPINSEKAEYQQIHTALLSGLLSHIGLKEAEKQQYLGARNAHFAIFPNSVLFKKQPKWVMAAELVETSKLWGRMVAEIEPEWIEPLAEHLIKKSYSVPLWSKSRGAVIADEKVTLYGVPIVAVRPVNYGAIDPTVSREIFIQSALVEGGWNTKHKFFKENQRLVREVEELEHKSRRRDILVDDRTLFEFYDQRIGTEVVSQKHFDTWWKKAQQKDPELLNFEHSFLINDDAEQVSKLDFPNFWHQGNLKLKLTYQFEPGTDADGVTVHIPLPLLNQVEMTGFDWQIPGLREELVIALIKSLPKSYRRNFVPAPNYAQAFLSRAVPLEKPLLDTLIYELRRMTGVTVEAEHWNWEQIPSHLKMTFRVVDENGKKIAESMNLDELKFNLKDRVQESISAVADDGIEQSGLHIWSFADLPQCYEQKQRGFSVKAFPAIVDEKDAVGIKLFETEFEQSVAMQQGLRRLLLLNVPSPIKYLHEKLPNKAKLGLYFTPFGRVLDLIDDCIACAVDKLIADFGGFVWDEAGFEKLRDFVRENLNEVTVDIAQKVEQILTLTYQLNQRLKGKMDFTMAFALSDIKSQLAGLVYQGFVQKSGYDRLPDLQRYLQAVDKRIDKLAQDVNRDRAAMLRVEQVQQAYQQLLAKLPKSKPISDEVAEIRYMIEELRVSLFAQQLGTKYQISDKRIGNIISQY

hrpA

ATP-dependent RNA helicase HrpA

1300 amino acids

Not yet known.

Belongs to the DEAD box helicase family. DEAH subfamily.

149.028 kDa

MTEQQKLTFTALQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMAKEIDQAAGKVLLREAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADALNKLNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQASAYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHIALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRISHDVISARHFDSWWKKVSRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLNQVEESGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVKPLELPLLDSLERELRRMTGVTVDREDWHWDQVPDHLKITFRVVDDKNKKLKEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGQLPESYEQKRGNYKVKAWPALVDERDSVAIKLFDNPLEQKQAMWNGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELIDDCISCGVDKLIDANGGPVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALGLSDIKAQMGGLVYRGFVTGNGFKRLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARREDEDVKEIRWMIEELRVSYFAQQLGTPYPISDKRILQAMEQISG

hrpA

ATP-dependent RNA helicase HrpA

823 amino acids

Has RNA-stimulated ATPase activity and RNA helicase activity (PubMed:24367266). Involved in global regulation of gene expression (PubMed:21814569). Could be involved in RNA processing and post-transcriptional gene regulation (PubMed:24367266). Essential for both tick transmission and mouse infection (PubMed:24367266).

Belongs to the DEAD box helicase family. DEAH subfamily.

95.088 kDa

MNDFKLPIYKYKDELIKVLKNHNVLIVESPTGSGKTTQLPRIIYEAGFAKLGKIGVTQPRRIATVSIAEYIAKHIGVNVGEEVGYKIRFEEITSPKTKIKLMTDGVLLQELKKDTLLYEYDVIIIDEAHERSLNIDFILGLIKDISRKRDDFKIIVSSATINTKIFSKYFNNAPVVSIETITYPVQIIYNPPLLNTSKGMILKIKEIVLNVIKEKKAGDILIFLSGEKEIKETIKELQELNSKKNLIIFPLYGRMPKEAQEQIFMTTPKNKRKIIVSTNIAETSITIENIKIVIDSGKVKTNKFQTKTHTYSLQEVPISKSSATQRAGRAGRLSKGTCYRLYKREDYQLREDYQKEEIYRTDLSEVVLRMADIGIRDFTHFDFISKPSTHSIQTASKILKSLDAINNKNELTEIGKYMILFPLIPAHSRALVEAMINYPQAIYQTTIGLSFLSTSGIFLLPQNEEMEARQAHLKYKNPMGDLIGFVNIFEDFKKALNKEAFTKENYLDLQGLEEIANVQMQLENIISKLNIPIIQKGVFDNEGYLKSIMRGMRDYICFKTSKKKYKTIKAQNVIIHPGSLISTDSVKYFVAGEIIETTKMYARSIGVLKKEWIDDIILNEEFKHNDISSKENQITNTGQTKIINEIKIGKKIFKAEYKNNIYVIKINLETLKEIIFKNELNNQNNEDLKKIKIQLMHKNITVFNNKKFLETIEIVKNMGKDWHCIKKYETKNVNIDEPEKMKNLLECTMQFISFPPKKNALFLSLETDYSGNFRLKPKQNFIMAIEESIESIKSLIENKEYIQKLHFIKKLINKVYKKLNYFF

hrpA

Hypersensitivity response secretion protein HrpA

568 amino acids

Involved in the secretion of a proteinaceous elicitor of the hypersensitivity response in plants.

Belongs to the GSP D family.

60.44 kDa

MAAALLLWTAGTVCAAPIPWQSQKFEYVADRKDIKEVLRDLGASQHVMTSISTQVEGSVTGSFNETPQKFLDRMAGTFGFAWYYDGAVLRVTSANEAQSATIALTRASTAQVKRALTRMGIADSRFPIQYDDDSGSIVVSGPPRLVELVRDIAQVIDRGREDANRTVVRAFPLRYAWATDHRVTVNGQSVNIRGVASILNSMYGGDGPSDSGTAPRAQDRRLDSVAPGEASAGRAGTRALSSLGGGKSPLPPGGTGQYVGNSGPYAPPPSGENRLRSDELDDRGSTPIIRADPRSNSVLVRDRADRMAAHQSLIESLDSRPAVLEISASIIDISENALEQLGVDWRLHNSRFDLQTGNGTNTMLNNPGSLDSVATTAGAAAAIAATPAGGVLSAVIGGGSRYLMARISALQQTDQARITANPKVATLDNTEAVMDNRQNFYVPVAGYQSADLYAISAGVSLRVLPMVVMDGGTVRIRMNVHIEDGQITSQQVGNLPITSQSEIDTQALINEGDSLLIAGYSVEQQSKSVDAVPGLSKIPLVGALFRTDQTTGKRFQRMFLVTPRVITP

hrpA

Hrp pili protein HrpA

113 amino acids

Major structural protein of the Hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. Required for secretion of virulence proteins such as HrpW and AvrPto. The Hrp pilus functions as a conduit for protein delivery into the host cell. Also, affects the expression of TTSS-associated genes. Required for full expression of genes that encode regulatory, secretion, and effector proteins of the TTSS. HrpA-mediated gene regulation apparently is through effect on the mRNA level of hrpR and hrpS.

Belongs to the HrpA type 1 family.

11.387 kDa

MVAFAGLTSKLTNLGNSAVGGVGGALQGVNTVASNATLQKNILLGTGDSLSVDAQAKASKESDANGAKLIAMQAQETMKKQTMDVLNAIQAGKEDSTNKKISATATNAKGISY

hrpA

Hrp pili protein HrpA

108 amino acids

Major structural protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell. Also, affects the expression of TTSS-associated genes. Required for full expression of genes that encode regulatory, secretion, and effector proteins of the TTSS. HrpA-mediated gene regulation apparently is through effect on the mRNA level of hrpR and hrpS (By similarity).

Belongs to the HrpA type 1 family.

11.115 kDa

MSIISSLTNAGRGVVNTVGGAAQGINSVKSSADRNIALTKNTGSTDSIDATRSSISKGDAPSAELDGTANEENGLLRETSMLAGFEDKKEALSNQIVASKIRNSVVQF

hrpA

Hrp pili protein HrpA

108 amino acids

Major structural protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell. Also, affects the expression of TTSS-associated genes. Required for full expression of genes that encode regulatory, secretion, and effector proteins of the TTSS. HrpA-mediated gene regulation apparently is through effect on the mRNA level of hrpR and hrpS (By similarity).

Belongs to the HrpA type 1 family.

11.191 kDa

MNIMSSLTNAGRGVVNTVGGAAQGINSVKSSADRNIALTKNTGSTDSIDATRSSISKGDAKSAELDGTANEENGLLRETSMLAGFEDKKEALSNQIVASKIRNSVVQF

hrpA

Hrp pili protein HrpA

108 amino acids

Major structural protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell. Also, affects the expression of TTSS-associated genes. Required for full expression of genes that encode regulatory, secretion, and effector proteins of the TTSS. HrpA-mediated gene regulation apparently is through effect on the mRNA level of HrpR and HrpS (By similarity).

Belongs to the HrpA type 1 family.

11.006 kDa

MTIMSSLAGAGRGVVNTIGGAAQGINSVKSSADRNAALVSNTGSTDSIDATRSSISKGDAKSAELDGTANEENGLLRESSMLAGFEDKKEALSNQIVASKIRNSVVQF

hrpA

Hrp pili protein HrpA

69 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).

Belongs to the HrpA type 2 family.

7.021 kDa

MGLGGPLSSATSFASKTLEGAMSDSMAESAVAQAAKMKIDTQNSILDGKMDSATKEINSGHNAAKAIQF

hrpA

Hrp pili protein HrpA

68 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell. HrpA is required for the secretion of HrpN and DspA/E.

Belongs to the HrpA type 2 family.

6.914 kDa

MAGSSLTSASTSASKTLESAMGQSLTESANAQASKMKMDTQNSILDGKMDSASKSINSGHNAAKAIQF

hrpA

Hrp pili protein HrpA

68 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).

Belongs to the HrpA type 2 family.

6.841 kDa

MALGLSQVASQAASQTLDTAMAGSLTRAAGAQAQKIALDTENSILDGQMDSASKSLNSGQKAAKAIQF

hrpA

Hrp pili protein HrpA

68 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).

Belongs to the HrpA type 2 family.

6.841 kDa

MALGLSQVASQAASQTLDTAMAGSLTRAAGAQAQKIALDTENSILDGQMDSASKSLNSGQKAAKAIQF

hrpA

Hrp pili protein HrpA

67 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).

Belongs to the HrpA type 2 family.

6.855 kDa

MSGLLTSASSSASKTLESAMGQSLTESANAQASKMKMDTQNSILDGKMDSASKSLNSGHNAAKAIQF

hrpA

Hrp pili protein HrpA

66 amino acids

Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity).

Belongs to the HrpA type 2 family.

6.656 kDa

MGLSNAASLASMQTLDKAMASATAMTTAAQAQKVQTDAISSITDGQMDSASKAMNSGQKAAKAIQF