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hppE

Gene
hppE
Protein
(S)-2-hydroxypropylphosphonic acid epoxidase
Organism
Streptomyces wedmorensis
Length
198 amino acids
Function
Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.
Similarity
Belongs to the non-heme iron-dependent dioxygenase family.
Mass
21.337 kDa
Sequence
MSNTKTASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQLGRIAHVLGTSIGALTPPAGNDLDDGVIIQMPDERPILKGVRDNVDYYVYNCLVRTKRAPSLVPLVVDVLTDNPDDAKFNSGHAGNEFLFVLEGEIHMKWGDKENPKEALLPTGASMFVEEHVPHAFTAAKGTGSAKLIAVNF

Gene
hppE
Protein
(S)-2-hydroxypropylphosphonic acid epoxidase
Organism
Pseudomonas syringae
Length
190 amino acids
Function
Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.
Similarity
Belongs to the non-heme iron-dependent dioxygenase family.
Mass
21.317 kDa
Sequence
MDVRTLAVGKAHLEALLATRKMTLEHLQDVRHDATQVYFDGLEHLQNVAQYLAIPLSEFFVGQTQSDLDDGVKIARRNGGFKREEIRGGVHYYTYEHLVTTNQDPGLMALRLDLHSDDEQPLRLNGGHGSREIVYVTRGAVRVRWVGDNDELKEDVLNEGDSIFILPNVPHSFTNHVGGAKSEIIAINYG