hpnE

Gene

hpnE

Protein

Hydroxysqualene dehydroxylase

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

Length

418 amino acids

Function

Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP). Catalyzes the third (last) step, the reduction of hydroxysqualene (HSQ) to SQ.

Similarity

Belongs to the HpnE family.

Mass

43.828 kDa

Sequence

MSKTVHVIGAGISGLAAAIRLARAGLTVHVHEAMQQAGGRCRSYFDAQTGLVIDNGNHLLLSGNHAACEYARTIGTEAGLVGPERAEFDFIDLPANARWRLKLGGGKLPLWLFDANSRVPDTSIGDYLGLMPLLWAPTTKLIGDTINCSGPLYDRLVAPLLLAALNVDPPEGSAGLAGAVVRETLLAGGKACRPLIARDGLSAVLVEPAVAQLAARGPGVQFGHELRALTPAGDRVGALQFGGEDVVTLGPDDAVVLAVPPRPAASLLPGLKTPQEYRAIVNAHFNYAPPPGMPALTGVIGGVVEWLFAFPNRLSVTISNGDRLVDAPREQLAAEIWGEICKIAGISANLPPWQIVRERRATFAATPAQNALRPGPVTQWRNLYLAGDWTDTGLPATIEGSVRSGNRAADLVLAAGRA

Protein

Hydroxysqualene dehydroxylase: hpnE

Gene

hpnE

Protein

Hydroxysqualene dehydroxylase

Organism

Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

Length

414 amino acids

Function

Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP). Catalyzes the third (last) step, the reduction of hydroxysqualene (HSQ) to SQ.

Similarity

Belongs to the HpnE family.

Mass

45.492 kDa

Sequence

MSVTHIIGAGLAGLSAAVAITHAGGRVKIYEASAMAGGRARSYHDKKLGIEIDNGNHMLLSGNHSAKTYLKRIGAEHRFKSPKEAAFSFCDLSDKERFTIKLSNGPLPWWVLCAKSRVPHSKAKDYLALLSLLLADHNTKIGDLVPDNTALWRKLLDPFFVSVLNTPAREGAACLAAAVIRETLMKGGKACIPRIAYPNLASSFIDPALDYLKARGVEVDFRNRLRQIHFSGQDVASLEFAHQDVKLGKGDKVIIALPAWVVQSLIPDIETPDKYQAIINAHFLMKPTAAMPHIMGVVGGTADWIFTFENRISVTISAANHLLALEKEELVKRIWDDIQTVYAFKQDMPEWQVVTEKRATFEATVEQNNRRPPAVTAWNNLFLAGNWVRTGLPATIESAIRSGQTAADLALSHS

Protein

Hydroxysqualene dehydroxylase: hpnE