Protein
Modification methylase HpaI
Organism
Haemophilus parainfluenzae
Function
This methylase recognizes the double-stranded sequence GTTAAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the HpaI endonuclease.
Similarity
Belongs to the N(4)/N(6)-methyltransferase family.
Sequence
MDQRLICSNAIKALKNLEENSIDLIITDPPYNLGKDYGTTDDNLNFNKYLEFSHEWLEECYRVLKPHGTIYIFMGMKYISYIYKILEQDLGMYFNSWITWYYTQGIGKTRGYSPRHDDILMFTKHPKKFTFNLDRIRVPQKYYRSVNNMRGANPSNVWEFSHVHYCNKNRKPHPTQKPEALYERMILASSNEGDIVLDPFVGSGTLNFVCKHLNRSGIGIDINKEYIEMAKERLDSEFNGFDSIDERMKRCPNDLSDPVIRKQYIINHINWFLKNHENAREEFLNEVKTKYYKKMTQEEKRLLDKENNLSFDFS