Organism
Escherichia coli (strain K12)
Function
Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:10361310, PubMed:20105222). Its toxic effect is probably neutralized by antisense antitoxin RNA SokA (PubMed:10361310).
Similarity
Belongs to the Hok/Gef family.
Sequence
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE