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hok

Gene
hok
Protein
Protein Hok
Organism
Escherichia coli
Length
52 amino acids
Function
Toxic component of a type I toxin-antitoxin (TA) system. Part of the plasmid-stabilizing activity of plasmid R1; when R1 is lost cells die rapidly. When overexpressed kills cells within 5 minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:3019679). Its toxic effect is partially neutralized by antisense RNA Sok.
Similarity
Belongs to the Hok/Gef family.
Mass
6.082 kDa
Sequence
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK