Heme-degrading monooxygenase HmoA
Bacillus subtilis (strain 168)
Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
Belongs to the antibiotic biosynthesis monooxygenase family.