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hizr-1

Gene
hizr-1
Protein
High zinc activated nuclear receptor protein
Organism
Caenorhabditis elegans
Length
413 amino acids
Function
Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated.
Similarity
Belongs to the nuclear hormone receptor family.
Mass
46.736 kDa
Sequence
MQKVMNDPEDLGNCKICLQRADGIHFAVSSCRACAAFFRRTVILKLNYTCKEKGNCTVEKSLRNLCRSCRYTRCINEGMKIELVQLQRDSIGRKKSGASISIDPLFTPNVASSLSAIFKNEKEDVLSTSCTILSQMTSGYAMFLNIRRSTNTLVQSSVITPTFKMPKIELHASRFDSAKQVCKAEAHLVTDIVNSYFSPFNSLKFEDKVALFKNFFCYFSHTDRAYQSFKQFESDNLNDKILMPDGGFIKRTELGRFYENAEGVHTSAEDAAKIFQPALNYILDVIVDYMRRIHIIETEYLALLGFCLWDDAVPGLSKEAKSLAVQTQSKLLAELQNFYSSQNKDAVEITQRVGVLLLLVPKLTKCVIMLRENSVLAELFNYYEADVCCKNFKEDASVDLDCTSQCIVHTKND