Protein
Imidazole glycerol phosphate synthase subunit HisH
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
Sequence
MSTTPVRAAPEVLLLDYGAGNVRSAARALERAGMTVRVTDNAADVPHAPALVVPGQGHFRQVMEAFEHGGFHGPVLDAARAGVPLLGICVGMQLLFDGSEEAPGVPGLGLIAGQVRKFAPAPERKVPQMGWNALEARGDSPLLRGLGPDAYAYFVHSYYVPVDVPVTDGAVTDYGVPFWSALSRGNLHAAQFHPEKSGAVGLALLANFRRELAPA