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higA1

Gene
higA1
Protein
Antitoxin HigA1
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
149 amino acids
Function
Antitoxin component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Probably neutralizes the toxic effects of cognate toxin HigB1, which also requires SecB-like chaperone MT2006 (AC Q7D7P7). Autorepresses its operon (higB1-higA1-MT2006).
Mass
16.76 kDa
Sequence
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Gene
higA1
Protein
Antitoxin HigA1
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
149 amino acids
Function
In M.tuberculosis represses expression of the Rv1954A-higB1-higA1-Rv1957 operon promoter but not that of the higB1-higA1-Rv1957 operon.
Mass
16.76 kDa
Sequence
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA