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hemo

Gene
hemo
Protein
Hemotin
Organism
Drosophila melanogaster
Length
88 amino acids
Function
Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing.
Mass
10.05 kDa
Sequence
MDCFKVFEVVFQSEINPLLLIPAVATIALTLCCYCYHGYQWIRDRRTARIEEQQAQLPLPLSRISITPGCSMVATTKLTHSRNSVDIY

Gene
hemo
Protein
Hemotin
Organism
Drosophila melanogaster
Length
88 amino acids
Function
Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing.
Mass
10.05 kDa
Sequence
MDCFKVFEVVFQSEINPLLLIPAVATIALTLCCYCYHGYQWIRDRRTARIEEQQAQLPLPLSRISITPGCSMVATTKLTHSRNSVDIY