hel308

ATP-dependent DNA helicase Hel308

1195 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

138.674 kDa

MDKILEILKDFGIVELRPPQKKALERGLLDKNKNFLISIPTASGKTLIGEMALINHLLDGNKNPTNKKGIFIVPLKALASEKYEEFKSKYERYGLRIALSIGDYDEDEDLSKYHLIITTAEKLDSLWRHKIDWINDVSVVVVDEIHLINDETRGGTLEILLTKLKEFNVQIIGLSATIGNPDELAEWLNAELIVDDWRPVELKKGIYKNEAIEFINGEIREIKAVDNNDIYNLVVDCVKEGGCCLVFCNTKRNAVNEAKKLNLKKFLTEEEKIRLKEIAEEILSILEPPTEMCKTLAECILNGSAFHHAGLTYQHRKIVEDAFRKRLIKVICCTPTLCLNANTEILQESGFRKITELNKDEKVFALCGKEIKPVDGWKVHKTPQHEYNIVVKTVNGLEITTTPNHIFLVKENGSLKEKEAKDLKVGDYVATVDRIRVKEKDIDLSNGDLYFIGYFIGDGYTGVIEKNTLKATPDLAFNPKYPPNFDDSELHKKYFLKCRISKGVAHYIYSKKLRKIFNKLNMLTKDNKNIDAFCNLPLDKLAYLIAGLFDSDGYIYLNRKNIEFYSISEKLVEQLQFVLLRFGIHSSIRKKKTKTMVSPTNGKEYKCKDIYVLTIRDFMSIKRFYENIPLRHEEKRRKLEEIIKNKEIGQIPSEFVALRFTPIAKIWCDCGFSVDLTMFKPRTKRQRELNKKRVKLLFELLDGKKLITNYKEYYSKRKNPYFDFIVREKINGNNYYSLNEKGRVLMSLLNKHIKDKENLEEMYNFLVNLEKCPICGKPIHKEMRYSWKKECYDGDIYWDRIKEIKKIKVNDKYAYDIELPDDGSNSHYIVANGFIVHNSAGLNLPCRRAIVKDLTRFTNKGMRYIPIMEIQQCIGRAGRPGLDPYGEGIIVAKNDRDYLRAYQALTQKPEPIYSKLSNQAVLRTQLLGLIATGEIRDEYDLEWFIRNTFYAHQYGNLREVAKNINEVIRFLEENEFIIDFMPTELGKRVSELYIDPLSAKFIIDGLEEMENEEEIYYLYLISKTLEMMPNLRVYNSEELNLIDEMDSLGIKSFEIEDLEAFKTAKMLYDWINEVPEDEILKRYKIEPGILRYKVENAVWIMHALKEIAKLIGKSSDIPEKLEIRLEYGAKEDIIELLSIKYIGRVRARKLYNAGIRSIEDIINNPSKVASIIGEKIAKKILDELGVKFGQQKLSF

hel308

ATP-dependent DNA helicase Hel308

1125 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

129.202 kDa

MKVDELPIDERIKRVIKERGIEELYPPQAEALKSGVLEGKNLVLAIPTASGKTLVSEIVMVNKLLSEGGKAVYLVPLKALAEEKYREFKEWEVLGLRVAATTGDYDSTDEWLGRYDIIVATAEKFDSLLRHGASWIKDVKLVVADEVHLIGSYDRGATLEMILTHMLGKAQILALSATVGNAEELAEWLDASLVVSDWRPVELRKGVFHLGQLFWEDGKIDHYPENWESLVLDAVKKGKQALVFVNTRRSAEKEAISLSSKVSKLLTKPETRRLEELISSIEDNPTTEKLKRALKGGVAFHHAGLSRAERTLIEDAFRNGLIKVITATPTLCMHPDTYVVTKSGAKKVSELTEGDEVLTHTGTFKKVIQPLRREHKGRLLVIKAYGTVPVKITPEHMVWVVKQIRHKSHYSDGRQVIWWEFEGPEWMTAQELKERLESETDPKVSYMLLQPIPEPSVDADKIPLRKEVYVVNQHGKTDKLHPSVKRTPEYLPLNFETARLIGLWIAEGSTSKNGVIKFDISSNEEDLTEFITGTIRKYFPHAKIVVKDHERNRRTVRFCNKRFAEWLRENIGHGADNKSIPPLLLLNKNREVRLGLLRGLIEGDGYVRRESQRRANYISYSTVSPSLAYQLQLLVASLGYTSSIHRSIRTEGIGKTRKPIYDVKVSGKSYYSLLEELGFEVPQRGNRTYNVNRTWKNYLLLKVRSIEEEEYEGDVYNLEVEGDESYSVGFIVHNSAGINLPAFRVIIRDTKRYANFGWTDIPVLEIQQMMGRAGRPKYDKVGEAIIVARTEDPKKLIDRYIHGKPEKLFSMLANEQAFRSQVLALITNFGVEDFRELVDFLSRTFYAHQRGDTSSLEYKAKDIVYFLIENEFIDMDVENRFIALPFGRRTSQLYIDPLTAKKFKDAFPAIERNPNPFGIFQLLASTPDMATLTARRREMEDYLDLAYEMEEHLYSSIPYYEDSRFQGFLGQVKTAKVLLDWINEVPEARIYETYNIDPGDLYRILELADWLMYSLIELYKLFEPKEDVLQYLRDLHLRLRHGVREELLELVKLPNIGRRRARALYNAGFRSVEDILRAKPKDLLQVEGIGLKIIEGIYRHLGVEYTISEKEKPKKRKGNLYDFLK

hel308

ATP-dependent DNA helicase Hel308

799 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

86.768 kDa

MDVADLPGVPEWLPDHLRDDGIEELYPPQAEAVEAGVTEGENLVASIPTASGKTLIAELAMLSSVARGGKALYIVPLRALASEKQADFEEFEQYGLDIGVSTGNYESEGGWLADKDIVVATSEKVDSLVRNDAPWIEDLTCVVTDEVHLVDDGERGPTLEVTLAKLRRLNPDLQTVALSATIGNAEALATWLDAGLVDSDWRPIDLQKGVHYGQALHLEDGSQQRLSVQNNEKQTAAIVRDTLEDDGSTLVFVNSRRNAEAAAGRLANTVRPHLSTEERDQLADIAEEIRDVSDTETSDDLADAVADGAAFHHAGLSRGHRELVEDAFRDRLVKVVCATPTLAAGVNTPSRRVVVRDWRRYDGSAGGMAPLSVLEVHQMMGRAGRPGLDPYGEAVLIASSHDEVDELFERYVWADPEPVRSKLAAEPALRTHILATVASGFARSRKGLLEFLEQTLYASQTDDSGQLERVVDDVLTYLQRNDFLEIEAGELDATSLGHTVSRLYLDPMSAAEIVDGLRDWERGASDSTSASGSPADAQAEPPANSGFTTASELAEDADESDADRDPDDISALGLYHLVSRTPDMYQLYLRSGDREEYEMELFEREEELLGPTPSEFEEGRFEDWLSALKTARLLEDWATEVDEATITDRYGVGPGDIRGKVETAQWLLGAAESLASEVDLDAARAISEARIRVEHGVREELVDLAGVRGVGRKRARRLFQAGITDRAQLRDADKAVVLAALRGRRKTAENVLENAGHRDPSMEGVEPAPDVSVDLNDGADGDASAESTANDDQASLGDF

hel308

ATP-dependent DNA helicase Hel308

783 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

83.58 kDa

MRVADVPGLPGGVADHFEGEGVEELYPPQAEAVERGVTEGANLVASVPTASGKTLIAQLAMLSAIAEGGDSPTFSGDGTALYIVPLRALAGEKAQEFEAFERFGLSVGVSTGNYERDGARLADNDIVVATSEKVDSLVRNGAGWIDDLSCVVADEVHLVDDDHRGPTLEVTLAKLRQQVADLQVVALSATVGNAGELAAWLDAELVDSDWRPIELRTGVHYGQSLHYDDGTQAELSVGSGSQTAAVVADTLADDGSTLVFVNSRRNAEASARRLADVTGNALSSAERERLADIAAEIRGVSDTETSDELADAVASGAAFHHAGLAREHRELVEEAFRDRLVKAVSATPTLAAGVNTPARRVVVRDWQRYDGTAGGMQPLDVLEVHQMFGRAGRPGLDPYGEAVLLANSHDELEELFDRYVYADPEPVRSKLAAEPALRTHVLAAIATGFTTTEDGLHEFLGGTLYATQTDDTGRLRSVTGDVLRYLDRNGFVERDGAALRATATGQLVSRLYVDPMSAATIIDGLRDAARDATETDDEGAFRPASELGDDAALPADASVEPTPLGLYHLVSRTPDMYELYLRSGDREQYTEVAYEHEDELLGATPREEQAEFEDWLSALKTARLMADWASELDEERIAERYDVGPGDIRGKVETAEWLLNAAERLAGELDVECGPAVREARKRVQYGVREELLGLAGVRNVGRKRARRLYNAGVESRADLRNADKGVVLGAVRGRAATAERILETVGHPDPGMDGVAADTDAAPESGGEAGGDEGQASLGDFS

hel308

ATP-dependent DNA helicase Hel308

783 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

83.58 kDa

MRVADVPGLPGGVADHFEGEGVEELYPPQAEAVERGVTEGANLVASVPTASGKTLIAQLAMLSAIAEGGDSPTFSGDGTALYIVPLRALAGEKAQEFEAFERFGLSVGVSTGNYERDGARLADNDIVVATSEKVDSLVRNGAGWIDDLSCVVADEVHLVDDDHRGPTLEVTLAKLRQQVADLQVVALSATVGNAGELAAWLDAELVDSDWRPIELRTGVHYGQSLHYDDGTQAELSVGSGSQTAAVVADTLADDGSTLVFVNSRRNAEASARRLADVTGNALSSAERERLADIAAEIRGVSDTETSDELADAVASGAAFHHAGLAREHRELVEEAFRDRLVKAVSATPTLAAGVNTPARRVVVRDWQRYDGTAGGMQPLDVLEVHQMFGRAGRPGLDPYGEAVLLANSHDELEELFDRYVYADPEPVRSKLAAEPALRTHVLAAIATGFTTTEDGLHEFLGGTLYATQTDDTGRLRSVTGDVLRYLDRNGFVERDGAALRATATGQLVSRLYVDPMSAATIIDGLRDAARDATETDDEGAFRPASELGDDAALPADASVEPTPLGLYHLVSRTPDMYELYLRSGDREQYTEVAYEHEDELLGATPREEQAEFEDWLSALKTARLMADWASELDEERIAERYDVGPGDIRGKVETAEWLLNAAERLAGELDVECGPAVREARKRVQYGVREELLGLAGVRNVGRKRARRLYNAGVESRADLRNADKGVVLGAVRGRAATAERILETVGHPDPGMDGVAADTDAAPESGGEAGGDEGQASLGDFS

hel308

ATP-dependent DNA helicase Hel308

760 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

84.241 kDa

MMIRELDIPRDIIGFYEDSGIKELYPPQAEAIEMGLLEKKNLLAAIPTASGKTLLAELAMIKAIREGGKALYIVPLRALASEKFERFKELAPFGIKVGISTGDLDSRADWLGVNDIIVATSEKTDSLLRNGTSWMDEITTVVVDEIHLLDSKNRGPTLEVTITKLMRLNPDVQVVALSATVGNAREMADWLGAALVLSEWRPTDLHEGVLFGDAINFPGSQKKIDRLEKDDAVNLVLDTIKAEGQCLVFESSRRNCAGFAKTASSKVAKILDNDIMIKLAGIAEEVESTGETDTAIVLANCIRKGVAFHHAGLNSNHRKLVENGFRQNLIKVISSTPTLAAGLNLPARRVIIRSYRRFDSNFGMQPIPVLEYKQMAGRAGRPHLDPYGESVLLAKTYDEFAQLMENYVEADAEDIWSKLGTENALRTHVLSTIVNGFASTRQELFDFFGATFFAYQQDKWMLEEVINDCLEFLIDKAMVSETEDIEDASKLFLRGTRLGSLVSMLYIDPLSGSKIVDGFKDIGKSTGGNMGSLEDDKGDDITVTDMTLLHLVCSTPDMRQLYLRNTDYTIVNEYIVAHSDEFHEIPDKLKETDYEWFMGEVKTAMLLEEWVTEVSAEDITRHFNVGEGDIHALADTSEWLMHAAAKLAELLGVEYSSHAYSLEKRIRYGSGLDLMELVGIRGVGRVRARKLYNAGFVSVAKLKGADISVLSKLVGPKVAYNILSGIGVRVNDKHFNSAPISSNTLDTLLDKNQKTFNDFQ

hel308

ATP-dependent DNA helicase Hel308

756 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

84.006 kDa

MNIEELPLPSLLRDFLISKRGIRTLYPPQEEAIRAGLLNGENILMVSATASGKTLLAEVAAVNNVLVNDKKSLVAVPLKALAFEKLNDFNTYSELGIRVAASTGDYNSEDKWLGSYDVIITTYEKLDSLLRLKPSWIWNVGQLIIDEIHFINDDERGPIIESIVAKLRMLNLNPQIIGLSATIGNPEELANWLNAKLVKSDWRPVSLREGVYHKGVVTYVNDGEKRISGQGDSLINLTVDTLNDGGQVLVFSSSRQGAVRIARKLAEYICSSPVRYIDPGEAGKLAEEVRETSSSRILAEELTGLIKCGVSFHHAGLELEVRRVIEEGFRRGVLRVLASTTTLAAGVNLPARRVIVNEYRRYEPGYGFIEIPVMEYKQMAGRAGRPGLDPYGEAIIIVSSKDEVDYVIDKYIKSPPEYVKSNFMNPTSLKFHTLSAVASQYAETIDELVKFTSNTFAGFQGKLSAMIQANSVRRMISRIIDELVDYGFIIRNGDKLEATEVGAVVNRMYLDPDTAHVFIMGLRNLNSDADLNAYSLMLVVKSPKIPKVKVRRNELDELAQQAASMWSSIPLKPSDVDELVNYPEDYEDFLSEFKTAMALLEWINESNEDQIMKTYDVQPGDLRVLSDQAEWLIGALQELARTLGLSGNVVNGLRALRYRVKYGVNDELLELVVNLEGVGRVRARALYAAGYRSIEDLAKANVSDLTRIRGIGDKIAGSIIEQAHQLVKDGRVIKFNESTVKGKTRRGGGGLLDHMY

hel308

ATP-dependent DNA helicase Hel308

751 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

85.591 kDa

MTNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDENYNLTGKKGLFIVPLKALASEKFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTSEKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVILTKLKNINAQIVGLSATVGNPEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLIVDSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCKSLSECIKKGVAFHHAGLTYQHRKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIRRYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNEKDVEKAFLALTGPLENIYSKLSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNKFIETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPLSSEIIIEGLNELKEKINDMDRSNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLKISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGILRYKVDQARWMTYSSKEIAKLVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNPEKIISTFGDKVGKKILDEFGLKYGQQKLSGF

hel308

ATP-dependent DNA helicase Hel308

747 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

81.108 kDa

MDVSEVSGVPPWFADHLREEGIESLYPPQAAAVDAGVADGESLVASVPTASGKTLVAQLAMLSAIDRGGTALYIVPLRALASEKREEFAAFEEYGLSVGVTTGSYEDTGEWLADKDIIVATSEKVDSLVRNGAPWIDDLDCVVADEVHLVDDEHRGPTLEVTLAKLRRVNPNLQVVALSATVGNAGEMAEWLDAELVDSSWRPIELRKGVHYGQALHFGDGTQQELPVQRTEKPTEAVVRETLDEGGSTLVFVNSRRNAEGAAKRLAKTTVDGLDADERAALSSLAEEIRAVSDTETSDDLADCVEQGAAFHHAGCSSEHRSLVEDAFRDRLIKTICATPTLAAGVNTPARRVVVRDWRRYSGDAGGMQPLSVLEVHQMMGRAGRPGRDPYGEAVLLADSHDELDELLDRYVWADPEPVESKLAREPSMRTHLLATVASGFADSRSALLSFLDRTLYATQYRHGDGEDNLERVVDTTLSYLETNGFIDRDGDAIEATDLGHTVSRLYLDPMSAAEIIDGLADAASPTAMGLYQLVARTPDMYELYLRSGDREEYTMLAYEREAELLGELPSEFEEGRFEDWLSALKTARMLEDWASELDEDDIAERYGVGPGDIRGKVDTAEWLLGAAESLASEQDLADVSAIREARKRVEHGVGEELIDLAGVRGVGRKRARRLYDAGIETRADLRNADKSVVLAALRGREQTAENVLEAAGHQQPEMDGVTPDADVKESAAAAGTDDGQANLGDF

hel308

ATP-dependent DNA helicase Hel308

740 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

81.052 kDa

MKIAELNLPQALKDFYTGSGIPELYPPQAEAIRQGLLDGKNLLAAIPTASGKTLLAEMAMLKSIAEGGKAIYIVPLKALASEKYDRFLEFSKLPIKPDGVKVGIATGDFDSRDEYLGEKDIIVATSEKTDSLLRNGASWLSGLSVVVADEVHLIDSPNRGPTLEVTLAKLRKINVNLQILALSATIGNAKALAKWMDAALVQSEWRPTTLKEGVFYGRAITFKKEKRTVNNAGPDEVNSLVADTLEEGGQCLVFANTRKSSESIAQKVARSLSKKLQPAEKEQLAKLKQDVLRHAETDTCEKLAECVGNGVAFHHAGLKGEHRRIVEDGFRQNILKVIACTPTLAAGLNLPARRVIIRDYKRFDVNYGSVPIPVLEYKQMAGRAGRPRLDPYGEAVLIAKNYDEFGELMENYINADPEHITSKLGTEPAMRAHALSAVATDFCRSRQDLKAFMDTTFFAYQRGDLSHVIDNVLNFLLEENMIIESKGGSLKATDLGSLVSKLYIDPLSAALIAEGLEKAKKRPDVAEFGLLHLICSTPDVKSLYLRRGDYSWIIRYADEHASDFLSDVPDSYGDDVEFEQFLAGVKTAALAEMWINEKSEEAITTFFNIGPGDIRNLMETCTWLMHGTAEISALLGAPATRTARELAIRIENGASRELLDLITLKGVGRVRARKLYDAGYTSRDKLKAAEIPAIAAIPGIGDKLAVSIMSQLGRKVDHTPPETEEQPQVSGQSTLFSFDG

hel308

ATP-dependent DNA helicase Hel308

735 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

80.474 kDa

MSKGLYDIPSWATTETRTLAKLAGVERLFEPQYMALQAGVEKGENLVVAAPTGSGKTFIALVAIVNSLARAGGRAFYLVPLKSVAYEKYTSFSILSRMGLKLKISVGDFREGPPEAPVVIATYEKFDSLLRVSPSLARNVSVLIVDEIHSVSDPKRGPILESIVSRMLASAGEAQLVGLSATVPNAGEIAEWIGGKIVESSWRPVPLREYVFKEYKLYSPTGGLREVPRVYGLYDLDLAAEAIEDGGQALVFTYSRRRAVTLAKRAAKRLGRRLSSREARVYSAEASRAEGAPRSVAEELASLIAAGIAYHHAGLPPSLRKTVEEAFRAGAVKVVYSTPTLAAGVNLPARRVVIDSYYRYEAGFREPIRVAEYKQMAGRAGRPGLDEFGEAIIVAERLDRPEDLISGYIRAPPERVESRLAGLRGLRHFILGIVAPEGEVSIGSIEKVSGLTLYSLQRGLPRETIARAVEDLSAWGLVEVKGWRIAATSLGREVAAVYLDPESVPVFREEVKHLSFDNEFDILYLISTMPDMVRLPATRREEERLLEAILDASPRMLSSVDWLGPEEMAAVKTAVVLKLWIDEASEDTIYGEWGVHTGDLLNMVSTAEWIASGLSRIAPYLGLNSKVSHILSVIARRIKHGVKPELLQLVEIPGVGRVRARILFEAGYRSIEDLATARAEDLMRLPLIGPSTARQILEFLGRVDEAREAEAREMLARKGLLSYLEGDAVAGEEGE

hel308

ATP-dependent DNA helicase Hel308

730 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

80.958 kDa

MKIESLDLPDEVKRFYENSGIPELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAMLKSVLAGGKALYIVPLRALASEKFRRFQDFSELGIRVGISTGDYDRRDEGLGINDIIVATSEKTDSLLRNETAWMQEISVVVVDEVHLIDSADRGPTLEVTLAKLRKMNPFCQILALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFFDGTFFCKDKEKLIEQPTKDEAINLVLDTLREGGQCLVFESSRKNCMGFAKKATSAVKKTLSAEDKEKLAGIADEILENSETDTASVLASCVRAGTAFHHAGLTSPLRELVETGFREGYVKLISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEELLFLFEKYIEAGAEDIWSKLGTENALRTHVLSTISNGFARTKEELMDFLEATFFAYQYSNFGLSVVVDECLNFLRQEGMLEQDSDALISTMFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLVCSTPDMRLMYMRSQDYQDINDFVMAHAEEFSKVPSPFNIVEYEWFLSEVKTSLLLMDWIHEKPENEICLKFGTGEGDIHTTADIAEWIMHVATQLARLLDLKGAKEAAELEKRIHYGAGPELMDLLDIRGIGRVRARKLYGAGFKSTADLAGATPEKVAALVGPKIAERIFRQIGRREAVSEISDSERLEKSSQDGQSTISDF

hel308

ATP-dependent DNA helicase Hel308

730 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

81.074 kDa

MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAMLKSVLNGGKALYIVPLRALASEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVATSEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEITLSKLRRMNPSCQVLALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTIKEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLATCVRSGTAFHHAGLTTPLRELVENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEFVFLFEKYIEAGAEDIWSKLGTENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLEKDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRSQDYQEVNDYVMAHAGEFSKVPNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGIGEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKRIRYGAAPELMDLLDIRSVGRVRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGSSDGQRTISDY

hel308

ATP-dependent DNA helicase Hel308

729 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

80.841 kDa

MKIESLDLPDEVKQFYLNSGIMELYPPQAEAVEKGLLEGRNLLAAIPTASGKTLLAELAMLKSILAGGKALYIVPLRALASEKFRRFREFSELGIRVGISTGDYDLRDEGLGVNDIIVATSEKTDSLLRNETVWMQEISVVVADEVHLIDSPDRGPTLEVTLAKLRKMNPSCQILALSATVGNADELAVWLEAELVVSEWRPTELLEGVFFNGTFYCKDREKTVEQSTKDEAVNLALDTLKKDGQCLVFESSRKNCMAFAKKAASTVKKTLSAEDRNALAGIADEILENSETDTSTNLAVCIRSGTAFHHAGLTTPLRELVEDGFRAGRIKLISSTPTLAAGLNLPARRVIIRNYRRYSSEDGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLVAKSYKEFVFLFENYIEANAEDIWSKLGTENALRTHVLSTISNGFARTYDELMDFLEATFFAFQYSNFGLSTVVNECLNFLRQEGMLEKDDALIPTSFGKLVSRLYIDPLSAARIAKGLKGAKSLSELTLLHLVCSTPDMRLLYMRSHDYQDINDYVMAHASEFVKVPSPFDTTEYEWFLGEVKTSLLLLDWIHEKSENEICLKFGTGEGDIHSIADIAEWIMHVTSQLAGLLDLKGAREAAELEKRIHYGAAPELIDLLNIRGIGRVRARKLYEAGFKSSAELAEVDPEKVAALLGPKIADRIFKQIRGRGTSSGIIASEPPEKSPYSGQKTISDY

hel308

ATP-dependent DNA helicase Hel308

723 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

79.915 kDa

MQIQDLAIPEPLRQQYLGLGIRELYPPQAACVERGLLDGKNLLVAIPTASGKTLIAEMAMHRHIANGGKCLYIVPLKALASEKYEEFGNKGVKVGLSTGDLDRRDDALGKNDIIVATSEKVDSLLRNGARWIPDITLVVIDEIHLIDSPDRGPTLEMVIAKMRSKNPGMQLIGLSATIGNPKVLAGWLDAELVTSSWRPVDLRQGVFYDNRIQFAERMRPVKQVSKNYDDLNLCLDTIAEGGQCLVFVSSRRNAEAFAKRAAGAIKSEDAALAACAERLLEGTPTEMVKTLAACVAKGAAFHHAGLSRKERSIVEEAFRKNLLKCISSTPTLAAGLNLPARRVIIRDYLRFSAGEGMQPIPVSEYRQMAGRAGRPRLDPYGEAVLIAKEAEQVPELFEVYIEAEAEDVHSRIAEPTALYTHVLSLVASGFAGTRGELTEFMNRSFYVHEHKQGRLIHRAIDEALQFLITAEMVVEVGEHIGATELGTLVSRMYIDPRSAFAIVTTLREQEKYADLGLIQLICTTPDMPTLYAKNADLPALSRMLEVRGADIWLPPPLDDDAAETYYRAVKTAMLLSDWTDELSEEKICERYGVGPGDVFGMVENINWLLHATSQLARMFVPKFYGQIADCEICMKNGIRRELLPLVRLRGIGRVRARRLFNNGITSPEELSRHKKEDLVKILGSGIAEQVLEQLHPSKDTGKKEPPSGDKNTNPGQSTLFHFG

hel308

ATP-dependent DNA helicase Hel308

720 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Unwinds the lagging strand from forked DNA structures in a 3'-5' direction. PCNA, the DNA polymerase sliding clamp subunit, stimulates the helicase activity, and may alter substrate specificity. Unwinds branched DNA (Holliday junctions) in an ATP-dependent fashion; ss- and dsDNA stimulate ATPase to the greatest extent, although it preferentially binds DNA with a single-stranded region. Processes a RecA-mediated recombination intermediate between gapped circular and homologous linear dsDNA.

Belongs to the helicase family. Hel308 subfamily.

82.631 kDa

MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAMVHRILTQGGKAVYIVPLKALAEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLEVILAHMLGKAQIIGLSATIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGALIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFHHAGLGRDERVLVEENFRKGIIKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPIIEVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGKPEKLFSQLSNESNLRSQVLALIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPLSLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEEEYYEFKDRLYFDDPYISGYDPYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDIYRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYGIREELIPLMQLPLVGRRRARALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS

hel308

ATP-dependent DNA helicase Hel308

715 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

82.006 kDa

MKVGELNVSEKIKEILRERGIEELYPPQAEALTSGVLEGENLLVAIPTASGKTLIAEIAIANKLLEEGGKAVYIVPLKALAEEKFREFKDWERLGLKVAMATGDYDSKDEWLGKYDIIIATAEKFDSLLRHGSSWIRDVKMLVIDEIHLIGSRDRGATLEFIITQMLGRAQIIGLSATIGNPEELAEWLNAKLIRSDWRPVKLRKGVFYQGFVFWEDGGSERYNSWEELVYDAVKKGKGALVFVNMRRKAEKTALELAKKVKNYLDRKELRELRELAESLEENPTNEKLAKALLSGVAFHHAGLGRDERVLVEDNFRKGLIKVVVATPTLSAGINTPAFRVIIRDTWRYSEFGMERIPVLEVQQMMGRAGRPRYDEVGEAIIVSTTEEPSLVIDHYIKGKPEKLFSQLSNESILRSQILALIATFGYSEFKEIYDFLERTFYAHQGKDPYMLEEKIRRIIYFLLENEFIEVTLEDEIKPLPLGVRTTKLYIDPMTAKIFKDTLPRIEKNPNPLGIFHMISLAPDLTPLSYSKRETSMLEDEYYSLMDRLYFELDYENERKFFRAFKTALVLNAWINEVPEGEIVERFNVEPGDIYRIVETAEWLIYSLGEIAKVLEASQEVVDYVNTLRLRVKHGIREELIPLMELPMVGRKRARALYNAGFKDLESIRNAKPSELLRIEGIGAKIVEGIFKYLGKEVKITERPRKGTLDYFLNP

hel308

ATP-dependent DNA helicase Hel308

715 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

82.106 kDa

MKVEELRIDERIKEVLKKRGISELYPPQAEALTSGILKGENALIAIPTASGKTLIAEIAIVNRLLKEGGKAVYLVPLKALAEEKFKEFKDWEELGLKVAMATGDYDSKDEWLGGYDIIIATAEKFDSLLRHGSSWIRNVKVLVVDEIHLIGSRDRGATLEFIITQMLNRAQIIGLSATIGNPEELAEWLNAKLIKSDWRPVKLRRGVFYQGFVFWEDGKTEKFNSWEELVYDAIKRSKGSLVFVNMRRKAEKTALELSKKIRNFLTKKELRELKELAESLEENPTNEKLAKALQGGVAFHHAGLGREERVLVEENFKKGLIKVVVATPTLSAGINTPAFRVIVRDTWRYSEFGMERIPILEIQQMMGRAGRPKYDEVGEAIIVSTTEEPSTVMERYIKGKPEKLFSQLSNESILRGQILALIATFNFSSFREIYDFLERTFYAYQGKDPYTLEDRIRDIVYFLLENEFIEITLDDEIKALPLGIRTAKLYIDPMTAKIFKDTLPKIEKDPNPLGILHVISLTPDLIPLPYGKKELPMLEDEYYSFKDRLYFELDWEDERKFLRAFKTALVLNAWINEVPEGEIVEKFNVEPGDIYRIVETAEWLVYSLKEIAKTLEYSQDVINYLETLRVRVKHGIREELIPLMELPMIGRKRARALYNAGFRDLESIKNARPAELLEVEGIGAKIVEAILKHLGREVKIVQKPRKGTLDYYLHP

hel308

ATP-dependent DNA helicase Hel308

715 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. A low processivity 3'-5' helicase. Unwinds short dsDNA substrates with 3'-overhangs (25 bp dsDNA with 25 base overhang), less active on longer dsDNA substrates. Also unwinds the lagging strand of a stalled replication fork (but the leading strand was not tested). Binds ssDNA, but dsDNA about 35-fold less well. Able to displace streptavidin from biotinylated ssDNA, which is partially inhibited by DNA-binding proteins, suggesting it may play a role in stripping proteins from stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

81.507 kDa

MSLELEWMPIEDLKLPSNVIEIIKKRGIKKLNPPQTEAVKKGLLEGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWELIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPEWLNEVNYFVLDELHYLNDPERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLIEGVIYPERKKKEYNVIFKDNTTKKVHGDDAIIAYTLDSLSKNGQVLVFRNSRKMAESTALKIANYMNFVSLDENALSEILKQLDDIEEGGSDEKELLKSLISKGVAYHHAGLSKALRDLIEEGFRQRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNKKIAGYYDEIPIMEYKQMSGRAGRPGFDQIGESIVVVRDKEDVDRVFKKYVLSDVEPIESKLGSERAFYTFLLGILSAEGNLSEKQLENFAYESLLAKQLVDVYFDRAIRWLLEHSFIKEEGNTFALTNFGKRVADLYINPFTADIIRKGLEGHKASCELAYLHLLAFTPDGPLVSVGRNEEEELIELLEDLDCELLIEEPYEEDEYSLYINALKVALIMKDWMDEVDEDTILSKYNIGSGDLRNMVETMDWLTYSAYHLSRELKLNEHADKLRILNLRVRDGIKEELLELVQISGVGRKRARLLYNNGIKELGDVVMNPDKVKNLLGQKLGEKVVQEAARLLNRFH

hel308

ATP-dependent DNA helicase Hel308

715 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

81.379 kDa

MSLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTRKVHGDDAIIAYTLDSLSKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGGSDEKELLKSLISKGVAYHHAGLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGESIIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWLSEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDLECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDDHSDKLRILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH

hel308

ATP-dependent DNA helicase Hel308

708 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

77.17 kDa

MEVSELPLDARLIAVLKERGVGRLFPPQVEAVRAGIFDGRSVLLCTATASGKSLLAEVAAVKAGLEGRMALYAVPLKALAYEKLVHFSYYRGLVKVGVSTGDFDSDDRRLHEFDVVVVTYEKLDSLLRHRPNWLGLVGVVVVDEIHYLGDPRRGPVLESIVAKLRHLGLKTQFIGLSATVGNAGEVAAWLGARLVESSWRPVPLREGVYHGGVIRFSDGSMQRVNAPGDAEVALAVDAVAGGGQALVFTNSRSSTVRLAKAVAKAMEAAGLVPRGAKALAEEVLKASSSKIIGRELADLVARGVAFHNAGLELEVRRLVEDGFRRGLLKVVVSTTTLAAGVNLPARRVVVADYERFDPALGREEIPVLEYRQMAGRAGRPGLDPYGEAVLVARSKGEAEYLMERYVRGQVEGVRSHILAEPNLRAHVLGAVGGGYAKSLDDLVDFFSNTLGAAQMKTSLKLSILRSKIGGVVEELVEWGFLERDGDFVYATELGRQVARLYLDPEVAAGYIRLIKSLRAGNVPAYLYVVLTAPDFPRVRRGRADKRVVEGILAALDVEEDEEFEDLARTASMLMAWIEEVDEDVIYEKFDVAPGDLRVYVDLFQWLGNAAAKLARLVGREEHGKRLEVVTARVVYGVREELLGLVTSLRGVGRVRARTLYNFGYRTLEDIARATVREIASLPGFGEKLAESVIEQARQMLAEGLRGEV

hel308

ATP-dependent DNA helicase Hel308

708 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

80.5 kDa

MSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTARKVHGDDAIIAYTLDSLSKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILKQLDDIEEGGSDEKELLKSLISKGVAYHHAGLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGESIIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEAFAYESLLAKSVVDVYFDRAIRWLSEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGYKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDLECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDDHSDKLRILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH

hel308

ATP-dependent DNA helicase Hel308

705 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

79.452 kDa

MEEITVEDLPVDSKVKDIIKSRGIKKLNPPQTEAVKKGLIEDKRLLITTPTASGKTLMAELGMISHLLNKGGKAIYVTPLRALTSEKYSTFKDWEKLGFKVGVTSGDYDTDDPWLRNFDIIVTTYEKLDSLWRHSAEWLKDIDYFVLDEFHYMNDGDRGPVVEGVAVRAKRQGTILALSATIGNAKDVAKWLNADIVATNWRPVPLKEGVMYSEGKKGHIILYSDGTTNKLKGDDPIIAYTLDILSKGGQVIVFRSSRKYAETTAMKISQYMNFVKLDDKKLLETAERIKEVEDAGSNEKEVLYNLIVRGVAFHHAGLSKGLRDIIEASFRERIIKVITATPTLAAGVNLPARAVVIGDIYRFNRKIVGFTEMISTMEYRQMSGRAGRPGYDNHGEAIILVRSKVEVDKVIDKYLHSDIEPIESKLGAEGPFFSFVLSLIASEGEITEDRLKDYVEDTMLSKQLVRKYYNNAIDWLSKNEFIKSNDDRLQLTKFGRRVSDLYLNPFTAVTIKNYLERAESPCDIAYFHLIAYTPDGPLVSVGRNEEDALLDNLDCELIIDEPDDELEFSNYISALKVAFILKDWIEEVDEDTILSKYGIGSGDLRAIIDTMEWLTYGAFHVSSILDLNQHTSVLEKLHKRIADGVKEELLELVRVPGIGRARARLLFNQGIKRPEDIVMKPERVKSLLGQNLGEKIVKEAARIIA

hel308

ATP-dependent DNA helicase Hel308

704 amino acids

An ATP, Mg(2+)-dependent DNA 3'-5' and 5'-3' helicase that may be involved in repair of stalled replication forks. Stimulated by both ss and dsDNA. Unwinds both leading and lagging strands in replication fork structures, unlike orthologs in P. furiosus and M. thermautotrophicus which only unwind the lagging strand and only have 3'-5' helicase activity. Preferentially binds dsDNA with overhangs or branched DNA. Able to anneal DNA substrates that could form a replication fork-like structure, has replication fork reversal activity (at least in vitro).

Belongs to the helicase family. Hel308 subfamily.

79.719 kDa

METISIDDLPLDIKIIDILKRRGIRTLNPPQSEAIRKGLLDGKRLLVTSPTASGKTLIAELGMINYLLSKGGKAIYITPLRALTNEKYNTFKDWETLGIKTGMTSGDYDTDDAWLENYDIIVTTYEKLDSLWRHKAKWLNEVSYFVLDEFHYLNDPERGPTVESVAIRAKKRGIVLGLSATISNGKEIANWLNAELVATNWRPVPLKEGIIYPEKKGFVVVYKDNTSRKVYGDDAIIAYTLDIVSKGGQVLVFRSSRKLAENTARKIVQYMNFVKLEDKKLLEIARKIKEVEDAGSNEKEDLYNLVLRGVAYHHAGLSKGLRDIIESSFRDRILKVIVATPTLAAGVNLPARAVVIGDIYRYNRKVVGYMDLIPVMDYKQMSGRAGRPGFDENGEAVVVVRNKREAEKVYERYLMSDVEPIESKLGSESAFYSFLISIIASEGEKTTEELMEYVKETLLPKELAKKYFRSGLDWLLQHDIFAEISDKITLTRFGRRISDLYINPFTAVTIREALEKNEKGCEIAYLHLLAYTPDGPSIGVSRAEEDALIDELNCELFVDEPEDEYEFSNYISALKVAYIVYDWVNEIDEDTILGKYGIGSGDLRAIIDTMDWLTYSGYHVASVLELKDHKDILEELHARVKDGVKPELIELVKIPGIGRVRARLLYQHDIKKPEDIVLNPEKVKQLLGPNLGEKIVREAARTIA

hel308

ATP-dependent DNA helicase Hel308

691 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

77.835 kDa

MKVEELAESISSYAVGILKEEGIEELFPPQAEAVEKVFSGKNLLLAMPTAAGKTLLAEMAMVREAIKGGKSLYVVPLRALAGEKYESFKKWEKIGLRIGISTGDYESRDEHLGDCDIIVTTSEKADSLIRNRASWIKAVSCLVVDEIHLLDSEKRGATLEILVTKMRRMNKALRVIGLSATAPNVTEIAEWLDADYYVSDWRPVPLVEGVLCEGTLELFDGAFSTSRRVKFEELVEECVAENGGVLVFESTRRGAEKTAVKLSAITAKYVENEGLEKAILEENEGEMSRKLAECVRKGAAFHHAGLLNGQRRVVEDAFRRGNIKVVVATPTLAAGVNLPARRVIVRSLYRFDGYSKRIKVSEYKQMAGRAGRPGMDERGEAIIIVGKRDREIAVKRYIFGEPERITSKLGVETHLRFHSLSIICDGYAKTLEELEDFFADTFFFKQNEISLSYELERVVRQLENWGMVVEDHHLAPTKLGSLVSRLYIDPLTGFIFHDVLSRMELSDIGALHLICRTPDMERLTVRKTDSWVEEEAFRLRKELSYYPSDFSVEYDWFLSEVKTALCLKDWIEEKDEDEICAKYGIAPGDLRRIVETAEWLSNAMNRIAEEVGNTSVSGLTERIKHGVKEELLELVRIRHIGRVRARKLYNAGIRNAEDIVRHREKVASLIGRGIAERVVEGISVKSLNPES

hel308

ATP-dependent DNA helicase Hel308

690 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Helicase with 3'-to 5'- polarity; able to unwind over 100 bp of DNA at 50 degrees Celsius. Unwinds forked DNA, preferentially on lagging strand forks; has weaker activity on Holliday junctions. Displaces the invading strand in DNA D-loops. Unwinds short oligonucleotides from dsDNA with 3'- but not blunt ends or 5'-ssDNA tails in an ATP-dependent manner. ATPase activity is stimulated by ssDNA but not dsDNA, protein binds ssDNA, dsDNA with 5'- or 3'-overhangs but not blunt ended dsDNA and replication forks. Replication forks bind both this protein and RPA. RPA does not stimulate the helicase activity of this protein.

Belongs to the helicase family. Hel308 subfamily.

78.51 kDa

MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAALKTVMEGGRVIYTVPLLSIQNEKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFSWNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPSVRIVALSATLSNMDEIAGWLDARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESLASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGLFNRQREIIEDEFRDGNILMITATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQMSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVERTTSRIIENRDALYRQIIAQVASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPEGFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSRDPVRDKLMEHGLFLMDVGNEEATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKIVKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVVGVRGLGRVRARKIIKTFGEDLRHVREDELKRIDGIGPKMAGAIRRYCERF

hel308

ATP-dependent DNA helicase Hel308

674 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

75.754 kDa

MKISELGYDRAFLQLFDGNDFQLYDHQRMAIEQIRKGRNVVVSVPTAAGKTLIAYSAIYETFQRNLKSIYIVPLRSLAMEKFSELSRLRDLGLKVKMSIGDYDDSPDFIKRYDAVILTSEKADSLLHHDPYILNDVGLLVLDEIHTIGDESRGPTLETVASIARYVNPDVRILALSATVSNAMELASWLDASLIKSDFRPVPLKTGILYRDQLYLDGKRRSGVSINQIIRETVEDNGQVLMFVSSRKKAEDTARDLAQIFGSDANIKISSDETNVYDDMLNEILPRGVAFHHAGLSNDQRAFIEREFRARRIKVIVATPTLAAGVNLPARLVIVRDITRWGSDGISYLTNMEIKQMIGRAGRPGYDQYGIGLIYVSSQSSYEAAKDYLSTDPEPVVSYLGNEAKVRFNTLAAISMGLARSPSDIMKFYETTLFFSQNGKDLLEEKISASLKFLEKNGFIKQSPDLRTTQLGKVTSDLYIDPESALRLVDFFDGPADVDHAIYYISLCREIVPFNIKDDYSAMEFLDDIGLIDGDIDAAKTAIVLRDWISEASYKYLYDKYGIAPGDMQARISMADWLSYSLAKLSSIYKPEVRRMLEILNLRIKEGIREDILQLVLIPGVGRVRARRLYDAGLRSIEDVASASPDRIKAIYGFSDTLANAIIRRARTIASKEVR

hel308

ATP-dependent DNA helicase Hel308

674 amino acids

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.

Belongs to the helicase family. Hel308 subfamily.

76.594 kDa

MKISDLGYDESFLDLFEGNDFELYDHQRMAIEQFRKGKNIMVSVPTAAGKTLIAYSAIYETFKKKLKSIYIVPLRSLAMEKYEELSRLRELGMRVKLSIGNYDDTPDFIKRYDVVILTSEKADSLMHHDPYMMEEVGLMVIDEIHMIGDEYRGPTLETVITTARYVNPETRIIALSATVSNASEIAEWLNASLIKSSFRPVPLKVGILYRNRLFLDGDARSDVDINLLVKETVDDGGQVLIFVSSRKRAEDMAKNLSQLFDPINDLKVSSEDANVYDDLLNEMLPHGVSFHHAGLSNEQRSFIEKAFRHRKLKVIVATPTLAAGVNLPARLVIVKDVTRYGDLGITYLSNMEVKQMIGRAGRPGYDQYGIGIIYAASANSYQVVKEYISEEPEPVDSYIGKPEKVRFNTLAAIAMGLATSQVEMEEFYRSTFYYAQNGEDEIPNRINESIKFLKENGFIKEKDSLRATEFGKMISNLYIDPESAIILKKYFDDNDDIDTALYYISLCREIAPINMQDDYAAMEFLESIGHIDGDIEAAKTALVLREWISEASTRRIFEMYGVAPGDLQARVNNADWISYSLAHLASIFKPERRRKLEILNMRIKEGIREELMDLVLIPAIGRVRARRLYEAGIHNVQELAFSDPSRIKMLYGFSDTLANAVVKRAKAIVSERIR