Protein
HEAT repeat-containing protein 1
Function
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Required for cell survival in the CNS through its role in rRNA synthesis and processing.
Similarity
Belongs to the HEATR1/UTP10 family.
Sequence
MTSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSLIACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMVTNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTAATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTPQLIREGLSCIIILLQNQKKGVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGLLQSVFQNLQLSSNLENTAAKLLLEEYVVCGNELPSDGISALNQRIQPTVRLFESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCGKYQILPESETSLMLSLNHPLPSVRNMAVDYLKEILNSEHNSFDEAFLKDALLERIKDDSPEVVLSALKALQHHMGLMDVEDTVSSLISLLHRIKPSADWCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTRAAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMDHATKRNTLENVCDILSRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLLQAYTIQPEQVSDQPADECLPVCVALGEFLQKISCGLSAEQEQGLLLLSLLRLFITTLKCPDSTFKGEPWWNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHLNEPMVLFKFLSLSWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQPVKTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSGLVSSPYHPLVEKLLKSSEEIIADSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCLQSPFCPSYTSKTLLRALQDVHGEPVLSVLLPAVERLLEQCAPDSCTFLPDEALLLQLLLSKFSEMSAPLLVKDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSPACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVSWPRVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEGGPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIMRLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILSQLMSTLGPSRFLWVLMLLLFKQHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEVKEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISISFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPTAKFWRALLSKSYDTLDKVNALLPMDTFITVMRGLVGNQLASVRRKAMELLNNKLQQRTKWLKEQITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVELVADKDEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKERKDLLNNEIYLLSAVTALQRASETLPHFISPYLLDTILQVTRLTLLARRLTSCPQLSVRLASLSSTLATKLPPRVLIPTITKCYCSMVDAQQNRLSPLMNILKEHISHMDKDQLNNHQSELTSFFLSALDFRAQHCQGDLKKTAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADRIADKLKGLFVLFAGQLVKPFSDLLHQLNISHTDKAFFDSEDESDDDSDEEADDNVTKSSLLLQYVLDCLHKIFLYDTQHFLSKERADALLCPLVDQLENMLGGEETYKSRITTHLVPCIAQFAVAMRDDSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEDECEEVEHQVQKVIQEMETILGEPLQSYF