Protein
Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit C
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.
Similarity
Belongs to the HdrC family.
Sequence
MSEELLKLLKAEGLDLLSCMHCGICTGSCPSGRHTGLNTRRIIRDARKNRAAVLSDYDLWLCTTCYTCQERCPRGIPITDAILELRRLAVREGLMLPEHRFVSEMVLECGHAVPLDEETKKKREELGLDPIPETVQKDPEALEGLKTLLKTCKFDELVAKK