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Ferredoxin:CoB-CoM heterodisulfide reductase subunit A

793 amino acids

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

Belongs to the HdrA family.

86.803 kDa

MRIGVYVCHCGLNIAGVIDVSALEEMAGELEDVVLAREVQFLCSDSGQEGIIKDIKDNKIDRVVIAACSPRLHEKTFRHVMEKADLNPYLMEMVNIREQCSWVHADDPQMATQKAFDLIRMGVAKARFLRELSATSSKASRNVLIIGGGVAGIEAALNLAEAGFPVTMVERESTIGGKMALMNEVFPTNDCSICVLAPKMTEVQNHPNITLYTYSEVTDISGSVGKFHVRVTRKPRFVLEDKCKGCVDLCSEVCPVEIENPMNYGIGKSRAIYMPIPQSVPQVVLIDPDHCVGCGLCQLACPAEAVDYEQKPEEIEFEAGAVIVSTGYQLFDASRKKEYGFGKYPDVITNMQLERMLNSAGPTGGRVLVPSTGQPPESVAFIQCVGSRDKTVGNEHCSRVCCMAALKNSQMVKERYPGTDITIHYIDIRAAGEMYEEYYARTQGMGVDFIRGKVAEVYAGEDGRPVVRYENTLESRVEEEAHDLVVLSTGYEPSKAAEGIGRMLNLARRPDRFFASAHPKMRPVDAPVSGVFLAGCASGPKEIQVSIAQGSACASKVMQLLGTGELEADPMGAHVDPDKCIGCRTCVEVCKFGKISIVDKKAVVDEVSCYGCGDCSAACPVGAIQMRNFENEQILAQVRAATAHKSQCPFVVAFLCNWCSYACADLTGMSRIHYPTNIRVIRTMCSARINPEFVLEALKGGADGVLVAGCRMDECHYIHGNFDAKKRMDVLKEIIKEIGLDPKRLRTLWISAAEGERFSNTITEFVKELEEIGPIGSELKREYTATGLEEVAK

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H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit A

659 amino acids

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

Belongs to the HdrA family.

72.392 kDa

MAEEKKEETMEEPRIGVYVCHCGVNIGGVVDIEAVRDYAAKLPNVVVSKDYKYYCSDPGQLEIQKDIKELGLNRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANLREQDSWVHMDDPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQTALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEDLCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEICERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVIKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEILENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGSEKLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALNEQAK

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H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit A

659 amino acids

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

Belongs to the HdrA family.

72.182 kDa

MAEEKKETMEEPKIGVYVCHCGVNIGGVVDVEAVRDYAAKLPNVVIAKDYKYYCSDPGQLEIQKDIKELGINRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANIREHDSWVHMDNPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQAALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEELCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEVCERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVLKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEVIENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGAETLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIIAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFKTEQIMAQIEAALNEPASK

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H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit A

658 amino acids

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

Belongs to the HdrA family.

71.281 kDa

MSDPKVGVFVCYCGANINGAVDCEAVKDFASELDGVAVAATYPFMCADPGQGLIKDAIKEHGLDRIVVAACTPKIHEPTFRGCLQDAGISPYYLEFVNIREHDAFVHMGDVEGATRKACEMIAGGVERAKKLEDVPQKVVDVDKSCMVIGAGIAGIQSALDLGDQGFKVYLVDKDESIGGRMAQLAKTFPTDDCAMUILAPKMVSAANHPNIELITFAEIKNIDGYIGNFDVTLEKKPRYVDEDTCTGCGACAAACPIEVPNEFDLGLGTRKAIYVPFPQAVPLLYTIDKEHCIDCGLCAKVCCAEAVRYDQKPQELNIKVGTIITATGYDEFDATKKEEYGYGVYDNVITTLEVERMINPAGPTHGHEIRPSDGKAPKRTVYIQCVGSRDEKVGNPYCSRVCCMFALKNAQLMKMHDPNAEVYICYMDIRAFGKGYEEYYKRAQDQFGVKFIRGRPANIFEDPETKNLTVRVEDTLMGEILEIDADLVVLSAGLEAKKDAGELAKMLGIDRGPEGFFKELHPKLAPVNTKVDGIAIAGVAQGPKDIPDTVAQAKGAASAVAIPMSQGQFKIEMIRATVNEEVCGGCKVCALMCPYNAITYEEKDGHLVAITDDVACKGCGACAAACPSGAMQLRYYRDEQVIGMIDGILNAAKMLEE

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CoB--CoM heterodisulfide reductase iron-sulfur subunit A

657 amino acids

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

Belongs to the HdrA family.

71.922 kDa

MSPRVGVFVCYCGANINGVVDCEAVRDFAEKLDGVVVAKTYPFMCADPGQNLIKEAIKEYNLDRVVVAACTPKIHEPTFRNCIKEAGLSPYYLEFVNIREHCSFVHMNDREKATKKAMELVAGAVERAKRLEDVPQKIVEVDKSCLIIGGGIAGIQAALDLGDQGYKVYLVEKEPSIGGRMAQLAKTFPTDDCALUILAPKMVSVANHPNVELITYAEVKNVEGFIGNFEVTIEKKPRYVDENICTGCGACAAVCPIEVPNEFDLGLGTRKAIYVPFAQAVPLVYTIDMDHCIRCGLCEKACGPGAIRYDQKPEEIKLKVGTIICAVGYDEFDATLKEEYGYGVYDNVITTLELERMINPAGPTGGHEIRPSDGKHPHRVVFIQCVGSRDAKVGKHYCSRICCMFALKNAQLIKQHDPSTEVYICYMDIRSFGKGYEEYYRRAQEQFGVKFIRGRPACIMEDPETKNLIVRVEDTLLGEIVEIEADLVVLSAGLSPRPDNPKLAKMLGLELSPDGFFKELHPKLAPVNTKVDGIAIAGVAQGPKDIPDTVAQAKGAASAVSIPMAQGQFRIEMIRAVVDEDVCGGCQVCAKMCPYNAITYVEKDGHLVAQVNDVACKGCGSCAGACPSGAMQLRYYRDEQIISFIDGVLEAHQKLES

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Dihydrofolate reductase HdrA

162 amino acids

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Belongs to the dihydrofolate reductase family.

17.98 kDa

MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYPEWDAAEWELDAETDHEGFTLQEWVRSASSR