HDAC9

Histone deacetylase 9

1011 amino acids

Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Belongs to the histone deacetylase family. HD type 2 subfamily.

111.297 kDa

MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS

hdac9

Histone deacetylase 9

596 amino acids

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.

Belongs to the histone deacetylase family. HD type 2 subfamily.

67.307 kDa

MLQTIYESESYFSSDGVAGREQLLAEQRMHAMIGKDIKSEFPIGLESISPLDLRTDLRTAVPVGDPGLREKQLQQELLIIKQQQQIQKQLLIAEFQKQHENLTRQHQVQLQEHLKLQQELLAMKQQQELLEREKEQKMEQQRKEQEAERHRQEQQLCHPRSKDRVKERAVASTEVKQKLQEFILSKSATKEPLTNGTSHSMGRHPKLWYTAAHHTSLDQSSPPPSGTSPTYKCPPPGNQDDFPLRKTASEPNLKVRSRLKQKVVERRSSPLLRRKDSIVSSSYKKRIFEVAESSVSSSSPVSGPSSPNNGPVAMEAEHETPVLSVNSRIENLVSHHHLVHHERSLSLLNLYTSPSLPNITLGLHATATQLNTSSSLKEQQKYDPQAPRQGVSMAGQYAGGIPTSSNHVSLEGKANSHQAILQHLLLKEQMRQQKILASGGTPVLHQSPLAAKDRVSPAGRVAHKLPRHRPLHRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKILSKSIEQLRQPEGHLEEAEEDLHGDNLMQEKSSSIDNTRSYSSTDLRTGPFGSVKVKEEPPDSENEIKTHLQSEQKSVFAQQVT

hdac9

Histone deacetylase 9

594 amino acids

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription (By similarity).

Belongs to the histone deacetylase family. HD type 2 subfamily.

66.214 kDa

MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMVPMVDPIMREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQELERHRREQQLPPLRGKERGRERAVASTEVKQKLQEFLLSKSATKDSPANGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGASPPYKYTLPGSQDAKDDFPLRKTASEPNLKVRSRLKQKVTERRSSPLLRRKDGNVVSSFKKRLFEVTESSVSSSSPGSGPSSPSNGPTSSITESETSVLPSSIQAEHLVSQQRLLIQDESVNLLSLYTSPSLPNITLGLPAVQSQISASSSFKEKQKGETQTLRPGVALAGQYGGNLPPSSTHPHVALEGKPNSSHQALLQHLLLKEQMRQQKLLVTGAVPLHPQSPLAAKERGSPGVRAAHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKMLSKSIEQLKQPGSHLEEAEEELNGDHSMQEERAPASSASIRAESSSAGEDDRIGQQVGAVKVKEEPPDSDEDTQTQQMESGEQAAFVQQVIGKDLAPGFVIKVII

Hdac9

Histone deacetylase 9

588 amino acids

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Belongs to the histone deacetylase family. HD type 2 subfamily.

65.687 kDa

MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQGVPLPSQYGSSIAASSSHVHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQVGAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQVIGKDLAPGFVIKVII