hapX

bZIP transcription factor hapX

491 amino acids

Transcription factor required for repression of genes during iron starvation (PubMed:21062375). Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis (PubMed:21062375). Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine (PubMed:21062375).

Belongs to the bZIP family. YAP subfamily.

53.052 kDa

MSTPSIAPAPAPLVPALAAKPAISPSPGPGTPGSITSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVNELEEQIKKIEDEHEIHIAAFKEQITNLSREVEQCRSEMTWWRDRCHALEKEVSVERSAKEAIVKEFRSSLSDREAVRSDKGLAPLTTSTPQARSSDRPDNGDASNNDSGEGREEVPLGCNDCSTSHCQCIEDAFTMPGVVAQEQSRRLDTTKPGLSEPQIKPDPEEMEIDFTSRFAATQQQDQSPTSVSSPAVDPCGFCSDGTPCICAEMAAQEEQRPRRNSFENNRLAPIQNLSQFTPPPSDGDVRSDVTLPPISQATNPCANGPGTCAQCLADPRRTLFCKTLAASRSPSAAPSGCCGGKGADGGCCQSRNTNVSRGRSGSNNNTSSGSSAAPSLTLSCADAYTTLSRHPNFSRATDELSTWLPKLHTLPKPRDFPLTDRGVPRAALEVEAASVMGVLRYFDRRFADK

hapX

bZIP transcription factor hapX

474 amino acids

Iron regulator crucial for the adaptation to iron starvation and iron excess, but is dispensable for virulence (PubMed:26960149). SreA represses the expression of hapX and the siderophore system during iron sufficient conditions by an iron-sensing mechanism, while hapX represses sreA and activates the siderophore system during iron-limiting conditions, resulting in efficient iron uptake and inhibition of iron-consuming pathways (PubMed:26960149). HapX targets include genes encoding a number of key iron-regulated factors such as the vacuolar iron importer cccA, as well as hemA, cycA and lysF involved in heme biosynthesis, respiration and lysine biosynthesis, respectively (PubMed:26960149). Activation of the vacuolar iron importer cccA during high iron conditions is essential for iron detoxification (PubMed:26960149).

Belongs to the bZIP family. YAP subfamily.

51.706 kDa

MSTSAGTPTSAHAPLSIAPASTPHQRSLSVKPLAAAPSPAPVTQCSITSKEWIVPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEEQIKKIEEENEREEAALKKTIQQQQQQIEEYKSQLLWWKNRCKAVEDELMTEKVAKEDAIKQLERINNSGRTTNNGNSVIGGCERCSSTRCQCIDDAFNIANITQMQTDDPHSKRGRSPSQGATQKRHRSNPEIKTEPEDLETDFTHSFSLRRHSRTGNDATTPILLDPCGFCQDGSPCICAEMAEDQPSDRSNQPSQLTKLPPIQNISQFTPPPSEGDVLSKSATLVSSNKSNPCANGPGTCAQCLADPRSSVFCKSLAASRASTRQEGGCCGGGGGKDGCCKNRSSGSDSSKQATSPITLSCADTFTTLSLHPKFASASNELSNWIPQLHTLPNPQNLNPDRRRDQNLTNRPALEVEAASVMGVLRYFDRRFADSK