About Products Protein Database Contact

hamp

Gene
HAMP
Protein
Hepcidin
Organism
Canis lupus familiaris
Length
85 amino acids
Function
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Similarity
Belongs to the hepcidin family.
Mass
9.172 kDa
Sequence
MALSTRIQAACLLLLLLASVASVSVLPHQTGQLTDLRAQDTAGAEAGLQPTLQLRRLRRRDTHFPICIFCCGCCKTPKCGLCCKT

Gene
hamp
Protein
Hepcidin
Organism
Larimichthys crocea
Length
85 amino acids
Function
Has very strong antibacterial activity against the marine Gram-negative bacteria V.alginolyticus (MIC=24 uM), V.fluvialis, V.harveyis (MIC=12 uM) and V.parahaemolyticus (MIC=6 uM). Has antibacterial activity against the Gram-negative bacteria A.hydrophila (MIC=6 uM), E.coli (MIC=24 uM), and E.coli BL21(DE3)plysS (MIC=6 uM), and the Gram-positive bacteria B.cereus (MIC=24 uM), B.subtilis (MIC=6 uM), C.glutamicum (MIC=3 uM), M.luteus (MIC=3 uM), M.lysodeikticus, S.aureus (MIC=6 uM) and S.epidermis (MIC=12 uM). Possesses antifungal activity against A.niger (MIC=24 uM), F.graminearum (MIC24 uM) and F.solani (MIC=24 uM), but lacks antifungal activity against the yeasts P.pastoris GS115 and C.albicans.
Similarity
Belongs to the hepcidin family.
Mass
9.685 kDa
Sequence
MKTFSVAVAVAVVLAFICLQESSAVPANEEQELEQQIYFADPEMPVESCKMPYYMRENRQGSPARCRFCCRCCPRMRGCGICCRF

Gene
hamp
Protein
Hepcidin
Organism
Morone chrysops x Morone saxatilis
Length
85 amino acids
Function
Antimicrobial activity against Gram-negative bacteria such as E.coli.
Similarity
Belongs to the hepcidin family.
Mass
9.484 kDa
Sequence
MKTFSVAVAVAVVLAFICLQESSAVPVTEVQELEEPMSNEYQEMPVESWKMPYNNRHKRHSSPGGCRFCCNCCPNMSGCGVCCRF

Gene
HAMP
Protein
Hepcidin
Organism
Pongo abelii
Length
84 amino acids
Function
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).
Similarity
Belongs to the hepcidin family.
Mass
9.374 kDa
Sequence
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARAGWTPMLQRRRRRDTHFPIYIFCCGCCHRSKCGMCCKT

Gene
Hamp
Protein
Hepcidin
Organism
Rattus norvegicus
Length
84 amino acids
Function
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Similarity
Belongs to the hepcidin family.
Mass
9.286 kDa
Sequence
MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT

Gene
HAMP
Protein
Hepcidin
Organism
Homo sapiens
Length
84 amino acids
Function
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).
Similarity
Belongs to the hepcidin family.
Mass
9.408 kDa
Sequence
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT

Gene
Hamp
Protein
Hepcidin
Organism
Mus musculus
Length
83 amino acids
Function
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
Similarity
Belongs to the hepcidin family.
Mass
9.352 kDa
Sequence
MALSTRTQAACLLLLLLASLSSTTYLHQQMRQTTELQPLHGEESRADIAIPMQKRRKRDTNFPICIFCCKCCNNSQCGICCKT

Gene
HAMP
Protein
Hepcidin
Organism
Sus scrofa
Length
82 amino acids
Function
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Similarity
Belongs to the hepcidin family.
Mass
8.771 kDa
Sequence
MALSVQIRAACLLLLLLVSLTAGSVLPSQTRQLTDLRTQDTAGATAGLTPVAQRLRRDTHFPICIFCCGCCRKAICGMCCKT

Gene
hamp
Protein
Hepcidin
Organism
Oncorhynchus mykiss
Length
61 amino acids
Function
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Similarity
Belongs to the hepcidin family.
Mass
6.946 kDa
Fragment
single
Sequence
LQVLTEEVGSIDSPVGEHQQPGGESMRLPEHFRFKRXSHLSLCRWCCNCCHNKGXGFCCKF