gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium leprae (strain TN)

Length

1273 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state (PubMed:17325221). Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

141.218 kDa

Sequence

MTDITLPPGDGSIQRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVSGNSLVRLLFGKSIRIGDIVTGAQFNSDNPIDLKVLDRHGNPVVADYLFHSGEHQTYTVRTTEGYEITGTSNHPLLCLVNVGGIPTLLWKLIGEIRSGDYVVLQRIPPVEFGPADWYSTMEALLFGAFISGGFVFQDHAGFNSLDRDYFTMVVNAYDTVVGGLRCISSRITVSGSTLLELDVYNLIEFKKTRLSGLCGQRSADKLVPDWLWHSPSTVKRAFLQALFEGEGFSSILSRNIIEISYSTLSERLAADVQQMLLEFGVVSERYCHTVNEYKVVIANRAQVEMFFTQVGFGVTKQAKLIRDVVSMSPCVGMDINCVPGLATFIRKHCDNRWVEEDSFNQHNVDCVQHWHHHSAEIVGHIADPDIRAIVTDLTDGRFYYARVASVTDTGIQPVFSLHVDTEDHSFLTNGFISHNTEARLTPLAMEMLREIDEETVDFISNYDGRVQEPMVLPSRFPNLLANGSGGIAVGMATNIPPHNLYELADAVFWCLENHDADEETMLVAVMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRTGRLAGISNVEDQGSDRVGVRIVIEIKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQMICYYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVITLIRASQTVDIARVGVVELLDIDDIQAQAILDMQLRRLAALERQRIIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEESADGVSVKVMISRSRVLSFFGSDSNTSPDRT

Protein

DNA gyrase subunit A: gyrA

Gene

GYRA

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial

Organism

Arabidopsis thaliana

Length

950 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

104.538 kDa

Sequence

MTPVLCHSTASIPNPNSLMSLSSTLRLSSSLLRRSFFRFPLTDPLCRLRRTEPSATRFFSSRTPRSGKFVVGAGKRGDEQVKEESGANNGGLVVSGDESRIVPFELHKEATESYMSYALSVLLGRALPDVRDGLKPVHRRILFAMHELGMSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVRMAQSFSLRCPLIQGHGNFGSIDADPPAAMRYTECRLDPLAEAVLLSDLDQDTVDFVANFDNSQKEPAVLPARLPALLLNGASGIAVGMATNIPPHNLGELVDVLCALIHNPEATLQELLEYMPAPDFPTGGIIMGNLGVLDAYRTGRGRVVVRGKAEVELLDPKTKRNAVIITEIPYQTNKATLVQKIAELVENKTLEGISDIRDESDRNGMRVVIELKRGGDPALVLNNLYRHTALQSSFSCNMVGICDGEPKLMGLKELLQAFIDFRCSVVERRARFKLSHAQQRKHIIEGIVVGLDNVDEVIELITKASSHSSATAALQSEYGLSEKQAEAILEITLRRLTALERKKFTDESSSLTEQITKLEQLLSTRTNILKLIEQEAIELKDRFSSPRRSMLEDSDSGDLEDIDVIPNEEMLMAVSEKGYVKRMKADTFNLQHRGTIGKSVGKLRVDDAMSDFLVCHAHDHVLFFSDRGIVYSTRAYKIPECSRNAAGTPLVQILSMSEGERVTSIVPVSEFAEDRYLLMLTVNGCIKKVSLKLFSGIRSTGIIAIQLNSGDELKWVRCCSSDDLVAMASQNGMVALSTCDGVRTLSRNTKGVTAMRLKNEDKIASMDIIPASLRKDMEEKSEDASLVKQSTGPWLLFVCENGYGKRVPLSSFRRSRLNRVGLSGYKFAEDDRLAAVFVVGYSLAEDGESDEQVVLVSQSGTVNRIKVRDISIQSRRARGVILMRLDHAGKIQSASLISAADEEETEGTLSNEAVEAVSL

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial: GYRA

Gene

GYRA

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial

Organism

Arabidopsis thaliana

Length

950 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

104.538 kDa

Sequence

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial: GYRA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)

Length

940 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

103.175 kDa

Sequence

MSDHTNPPSAPPDDDPNGGSLLMPVTLEEEMSRSYLDYAMSVIVSRALPDARDGLKPVHRRILYGMQESGYTADKPYRKSARINGDVMGKYHPHGDAAIYDALVRLAQPFSLRVPLIDGQGNFGSMDGDPAAAPRYTEARLARSASFLLNDIDRDTVDFQPNYDDSEMEPRVLPASYPNLLVNGADGIAVGMATKIPTHNPTEVIDATLAMIDNPDITLDELMTVIPGPDFPTGGLILGRSGIRSAFETGKGSITVRARTDFEEVRGGRQAIVISEIPYQVNKATLQERMAELVRAKQIEGISDIRDESDRSGVRVVIELKRDATPDVVLNHLFRFTQLQISYGINMLALDGGQPRLMGLRDVLSTFIRFREDVILRRARFELNKARDRAHLLVGLAIAVANIDEVIRLIRQSPDSTSARIALMERDWPAADVAPLLTLIDDGGNVLTEAQTVRLTEVQARGILELRLQRLTGLERDKIHNEMQEVAARIGELLEIIGSHIRRMEVMREELAVIRAELNSPRRSEINDSLADQDDESLIEPGQMVVTITRDGFIKRTPLDVFRQQHRGGRGRAAASMRGDDIVTRSFNAHTHQWVLFFSSGGKAYRQKVWRLPEAGPTAKGRALVNLLPELGSDGITAVLPLPQDESLWEGLHLVFATASGGIRRNRLSDFKNVRASGLIAMKLDEGDRLIGVATCREGDDIMLASRLGRCIRFQANEDTLRVFAGRESSGVRGMKLAQGDEVISLSVLRHVEATPEERAAYLRYASARRRSAAGEEDQIDAEVMEADDSEVTVDDTALSPERIAGLEEAEEFLLTVTIAGFGKRSSAYDYRVSGRGGQGIANINLAPRNGRAVAATFPVRPGDDVMLVTDAGRLIRVPADQVRITGRSTMGVTLFRVDKDEVVTSVFPVLETESVDDNGDDADSVAPAAPDGQVTDSDD

Protein

DNA gyrase subunit A: gyrA

Gene

GYRA

Protein

Probable DNA gyrase subunit A, chloroplastic/mitochondrial

Organism

Oryza sativa subsp. japonica

Length

939 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

103.168 kDa

Sequence

MALSAALRLPLPRLLWGPTGSLLAAAAAASRRRAAVVAVPAVRFLSSSSSSSDGSRSVQPLRAGRDERAAAGEGGAAVKERVVPVELHKEATEAYMAYAMSVLLGRALPDVRDGLKPVHRRILYAMHEMGLASRRPFRKCARVVGEVLGKFHPHGDSAVYETLVRMAQDFSMRYPLVQGHGNFGSIDADPPAAMRYTECRLDVGCFFFLDIDAIFIIGQVDFVPNFDNSQKEPSLLPARVPSLLLNGSSGIAVGMATNIPPHNLGELVDVLSVMIENPEATLQELLECMPGPDFPTGGTIVGNQGILEAYKTGRGRVVMRGKTDIETIDVKSKRSAIIIKEVPYQTNKSTLVERIAELVEEKVLEGISDIRDESDRSGMRVVIELKRGADPAIVLNNLYRHTALQSSFSCNMVAILDGQPKLMGLKEILQAFIDFRCSVIERRARFKLSQALERKHIVEGIVIGLDNLDSVIQIIRGTSNHAMARESLIKEFGLSDKQAEALLDITLRKLTSLERKKFVDEAKSLSEEISKLNELLSNKKLIFQLILQEATDLKNKFATPRRSFIEDSASTEVDDLDIIPNEEMLLILSEKGYVKRMKPNTFNLQNRGTIGKSVGKMRMNDNTSDFIVCQTHDHVLYFSDKGIVYSARAYKIPECTRAATGTPLVQLLSLSDGERITSIVPVNEFGEDQYLVMLTVNGYIKKVPLNAFSAIRTSGIISIQLAPGDELKWVRRCGDDDLVALASQNGMVIVNTCNKLRALGRKTRGVLAMKLKEGDKMASMDIIPATSHNMPETYSRVRDLSPPWLLFIADNGIGKRVPLNAFRQGNFNRVGLQGYKLPPDCSLAAVFVVGFSLTDDGESDEQVVLVSQSGTVNRIKVKDISIRSRSARGVILMRLEHAGKIQSASLISAAEEEEEQDPESASLISEAEEPEKQDPEVSA

Protein

Probable DNA gyrase subunit A, chloroplastic/mitochondrial: GYRA

Gene

GYRA

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial

Organism

Nicotiana benthamiana

Length

935 amino acids

Function

A type II topoisomerase that seems to play a critical role in chloroplast nucleoid partitioning by regulating DNA topology. DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

103.416 kDa

Sequence

MKLHTLNPQTPLTQSKPMAFSTGITPSRFSGLRKTSSELRFLSSVTPPPRKQLRPVSARRKEEEVGDEGNGSVILRDRGENEDRNGGERVVLTELHKEATEAYMSYAMSVLLGRALPDVRDGLKPVHRRILYAMHELGLSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVRMAQDFSLRSPLIRGHGNFGSIDADPPAAMRYTECRLEALTESMLLADLEQNTVDFVPNFDNSQKEPSLLPARVPNLLLNGASGIAVGMATNIPPHNLGELVDALSALIHNPEATLQELLEYMPGPDFPTGGIIMGNIGILEAFRTGRGRVVIRGKTDIELLDSKTKRAAIIIQEIPYQTNKASLVEKIADLVENKILEGVSDIRDESDRSGMRIVIELKRGSDPAIVLNNLYRLTALQSSFSCNMVGILNGQPKLMGLKELLQAFLDFRCSVVERRARFKLSQAQERNHIVEGIIVGLDNLDEVINTIRKASSNALAAASLRKEFELSEKQAEAILDISLRRLTALERNKFVEEGKSLRTQISKLEELLSSKKQILQLIEEEAIEIKNKFFNPRRSMLEDTDSGDLEDIDVIPNEEMLLAISEKGYVKRMKPDTFNLQNRGTIGKSVGKLRVNDAMSDFLVCRAHDKVLYFSDKGTVYSSPAYKIPECSRTAAGTPLVQILSLSDGERITSIIPVSEFAADQYLVMLTVNGYIKKVSLNYFASIRCTGIIAIQLVPDDELKWVKCCSNNDFVAMASQNGMVILTPCANIRALGRNTRGSVAMRLKEGDKVASMDIIPDALQKELDKTLEVQQRQYRSMKGPWLLFVSESGYGKRVPVSRFRTSPLNRVGLFGYKFSSEDCLAAVFVVGFSLGEDGESDEQVVLVSQSGTVNRIKVRDISIQSRYARGVILMRLEHAGKIQSASLISAADADPEDEDATAVAA

Protein

DNA gyrase subunit A, chloroplastic/mitochondrial: GYRA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Aeromonas salmonicida

Length

922 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

101.334 kDa

Sequence

MSDLAREITPINIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRLAQDFSMRYMLVDGQGNFGSVDGDSAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPNLLVNGSSGIAVGMAWNIPPHNLTEIVNGCLALIENGNLTIDELMTYITGPDFPTGAIINGRAGIVQAYRTGRGSVYVRAKAEVEVDDKTSRETIIIVHELPYQVNKARLIEKIAELVKEKKVEGISALRDESDKDACRIVIEIKRGESGEIVLNNLYKHTQLQTTFGINMVALDNNQPKVMNLKDILDAFLLHRREVVTRRTVFELRKARDRAHILEGLAVALANIDPIIELIRHSDTPADAKAKLVARGWELGNVAAMLEKAGDDAARPEWLEPEFGIREGQYFLTEQQAQAILDLRLHKLTGLEHGKILEEYQSLLDLIAELLFILASPERLMEVIRDELLAVREQYGDERPPEISASSAEINIEDLITPEDVVVTLSHQGYVKYQPITDYEAQRRGGRGKSATRIKEENFVERLLVANTHDTILCFSTRGKVYWLKVYQLPEASRGARGRPIINLLPLEEGERITAILPVKEYADDKYVFFATADGTVKKTSLSAFSRPLSSGIRAINLKEGDELIGVDITDGSNEIMLFSDAGKVVRFNEGSAAPMQPMLMSSDDVDGDDESVIDAGNDDDGSDNGEGSESTESKGTFKGVRPMGRTAGGVRGIRLLNGDKVVSLIVPRGEGAILTATENGYGKGTALTEYPTKSRGTQGVRSIKVDEDGKVSIDQVDDTDQIMLITNGGTLVRTRVSEVSIIGRNTGGVRLIRTGEDETVVGLQRIAESYEEENDVMAIDGEVSEGTDTAPDAGSAAADPEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Aeromonas salmonicida

Length

922 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

101.334 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Nocardioides sp. (strain ATCC BAA-499 / JS614)

Length

922 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

100.698 kDa

Sequence

MTETPTDGGSTPPSDGGGPGGRIEPVELQTSMQRAYIDYAMAVIVGRALPDVRDGLKPVHRRVLYAMYDGGYRPDRGFSKCSRVVGDVMGQYHPHGDTAIYDTLVRLAQPWVMRAPLIHGQGNFGSPGNDSAAAMRYTECRMAPLAMEMVRDINEDTVDFQPNYDGRSQEPVVLPARFPNLLVNGSAGIAVGMATNIPPHNLREVAEGARWALEHPDATREELQDALIERIKGPDFPNGALIVGRQGIEQAYRTGRGSITQRAVIEVDEDAKGRTNLVITELPYMVNPDNLALKIAELADSGKVQGISDVRDDTSDRTGQRLVVVLKRDAVARVVLNNLLKHTELQTNFSANMLALVDGVPRTLAIDQFISNWVTHQIDVIRRRTEYRLAEAEKRAHVLRGLVKALDMLDEVIALIRRSPDVAEAREGLIALLDIDEVQATAILDMQLRQLAALQRQKIIDDLAEIEARIADLKDILANVARQRQIVADELAEIVERYGDDRRSQIIAADGDLSMEDLIPDEELVVSITRGGYAKRTRADQYRTQRRGGKGVRGATLRGDDVVEHFIATTNHHWLLFFTTAGRVYRTKAYNLPEASRDAKGGHVAGLLSFQPDENIAQVLAIRDYDQAPYLVLATRDGLVKKTRLGDYNSPRQAGVIAINFRSEDDELIGAELVNPEDHILLVSRKGQSVRFQADDSQLRPMGRATGGVTGMKFRDGDSLLSMSVIRAAQVEAEEAAEASGESVEEMAETRGQWFGLHPQYVFTITDGGFAKRTQIPEYRVQSRGGIGIRAMKLANEDRGELVGAFIVEDGDEILSITSGGQVVRSPIDENFRPTGRSTMGVKFVTPKKGDSVAVVARSVEANGDDELDELDESALDEGGAEGGEVDESADAGTDATIDGSAASDVARTEGDTEPDPGESDG

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Neisseria gonorrhoeae

Length

916 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

101.53 kDa

Sequence

MTDATIRHDHKFALETLPVSLEDEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELKNNWNAAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQNFAMRYVLIDGQGNFGSVDGLAAAAMRYTEIRMAKISHEMLADIEEETVNFGPNYDGSEHEPLVLPTRFPTLLVNGSSGIAVGMATNIPPHNLTDTINACLRLLDEPKTEIDELIDIIQAPDFPTGATIYGLGGVREGYKTGRGRVVMRGKTHIEPIGKNGERERIVIDEIPYQVNKAKLVEKIGDLVREKTLEGISELRDESDKSGMRVVIELKRNENAEVVLNQLYKLTPLQDSFGINMVVLVDGQPRLLNLKQILSEFLRHRREVVTRRTLFRLKKARHEGHIAERKAVALSNIDEIIKLIKESPNAAEAKEKLLARPWASSLVEEMLTRSGLDLEMMRPEGLVANIGLKKQGYYLSEIQADAILRMSLRNLTGLDQKEIIESYKNLMGKIIDFVDILSKPERITQIIRDELEEIKTNYGDERRSEINPFGGDIADEDLIPQREMVVTLTHGGYIKTQPTTDYQAQRRGGRGKQAAATKDEDFIETLFVANTHDYLMCFTNLGKCHWIKVYKLPEGGRNSRGRPINNVIQLEEGEKVSAILAVREFPEDQYVFFATAQGMVKKVQLSAFKNVRAQGIKAIALKEGDYLVGAAQTGGADDIMLFSNLGKAIRFNEYWEKSGNDEAEDADIETEISDDLEDETADNENTLPSGKNGVRPSGRGSGGLRGMRLPADGKIVSLITFAPETEESGLQVLTATANGYGKRTPIADYSRKNKGGQGSIAINTGERNGDLVAATLVGETDDLMLITSGGVLIRTKVEQIRETGRAAAGVKLINLDEGETLVSLERVAEDESELSGASVISNVTEPEAEN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Fibrobacter succinogenes (strain ATCC 19169 / S85)

Length

903 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

99.633 kDa

Sequence

MSEEMVPGSQFKSLVEQDMQDCYLRYSMSVIVARALPDARDGFKPVHRRVMYSMHKLGVVPNKGTVKSARIVGDVIGKYHPHGDVAVYDTLARMAQDFSLRYPLVFGQGNFGSIDGDSPAAMRYTEAKMNNLGALMLEDLEKETVDMGPNYDESLEEPLVLPSALPNMIVNGTSGIAVGMATNMAPHNLREVGAAIHALAENPDLTGEDLMEYVKGPDFPTGAIVCGRSGIREAYLTGHGRVRVRARTEIETDAKGKPRIIVTEIPYMVNKAELCKKIADLVRDKRIDGITDIRDESSRDIRIVIELRRDAVGEVVLNNLFKYTQLQTTFSIYNLALVNNLPKLLTLKDLLQVYIDHRLDVITRATQFDLKKAAARLHIIEGLRIATQNIDEVVKIIRQSKTTEIAKQSLQDRFSLDEIQSQAIVDMRLAQLVGLNIEKLEAEYNELIATVADLKDILEKRERRVAIMLQKLDAVVDKYGDERRTTIGEAIDDSDDEDLIAEEEQVITLSKEGYIRRLPIDTFKAQNRGGKGIIGAGLKDEDNVEQIFTASTHSYLLVFTNKGRVYWTKVYRLPEGARNGKGRPIVNFVALTEGEKVQAIVPVRKFGGYFCLVFATKKGIINKMDLTLFSRPRKAGVNAISLDEDDELVKVQLVGMSAEEYEASKNASDDDSAEAVENAAEAQAAEAAIAEESESGDAEDFANRPIPKDLLMIATKNGQAVTFPISCFRAMGRGTHGVKGITLAEGDEVISLLWLKAGNKILTITEKGYGKRSEPGSYRVTRRGSKGVRNLNVTDKIGAAVFVESVADDYDLIITSKDGQVIRIKAADIRLTGRNAQGVKAITLRDGDVVKDATALPSVEDIEQDSADAKETFDKVKGVEVDDDSVVKDDAEKQEIGPTETEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)

Length

898 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

99.097 kDa

Sequence

MSDETTPQTPDEPVEGAPIPGTPQTGLDIEVEHYVLPEGAADKVEPVDLESEMKRSYLDYAMAVIVGRALPDVRDGLKPVHRRVLYAMYDGGYRPDRAFNKSARVVGDVMGNYHPHGDTAIYDALVRLIQDWVQRYPLALGQGNFGSPGNDGAAAQRYTETKMAPLAMEMVRDIDEDTVDMQDNYDGKQQEPVVLPARYPNLLVNGSSGIAVGMATNIPPHNMREVAAGVQWYLEHPEATREELLEALLARVHGPDFPTGAQILGRKGIEEVYRTGRGPITMRAVVNVEEIQGRTCLVVTELPYMTNPDNLAAKIAEMVRDGKISGIADMRDETSGRTGQRLVIVLKRDAVAKVVLNNLYKHTELQSNFSANMLALVDGVPRTLSLDGFVHHWVKHQIDVIVRRTAFRKRKAEERAHILRGLLKALDMLDEVIATIRRSASADVAREALKELLDIDDVQAQAILQMQLRQLAALESQKIQDEYDDLMAKIAEYNRILESPQRQREVISEELAEIVAKHGDDRRTEIMAGFDGDMSIEDLIPEEEMVVSITRGGYVKRTRIDQYRSQARGGKGVRGATLRGDDVVEHFLTVSTHHWLLFFTNFGRVYRIKTYELLEAGRDAKGQHVANLLAFQPDERIAQIQPLVDYGRAPYLVLATRGGLVKKTPLLDYDTNRTAGLIAIKLREGDELVSARVVSPDDDLILISHKGQSLRFTATDEALRPMGRATSGVTGMKFRDDDSLLTMDVVEEDGYVFTVTDGGFAKRTHVDEYRLQNRGGLGIKVAKLVDDRGELAGGLVVREDQEVLVVMASGKVVRSAVAGVPAKGRDTMGVIFAKPDKRDRIVAVTLNNEQEMEAKADAEAEAGPDVPLDADIDPTDPVAAPEDALTQDAGEGADGGEQ

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycoplasma arthritidis (strain 158L3-1)

Length

898 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

100.871 kDa

Sequence

MSDDKKDEEKLKKSDENFDDDSKYYEFDDTIKKVFEEEKAKEEDEDEEEIPQEKEGYQVKSQLLETEQNGLQPADLAKVMKSSFIEYAMSVIVSRALPDARDGLKPVHRRILYGMSELGMFHTAPHKKSARIVGDVLGKYHPHGDSSVYEAMVRMAQDFSLRYPLIDGHGNFGSIDGDEAAAMRYTEARMSKIAGVMVDGIKKNTVDFIDNYDGTEKEPTVLPSRFPNLLVSGTSGIAVGMATNIPPHNLGEIIDAVCALAKNPEITIDGLMEFVLAPDFPTGATIFNKAGLIEAYKTGRGSITMRAKANIQELANGKSKIIITEIPYEVKKTEIMEKIADHLKNKRIEGISDFRDESNRDGIRVVIDVKKNAVPEVILNTLYKLTRLQTNFSFNMIALVNGEPKLLNLKECLQVYLDHQIDVTRRRLQFDLEKDLARAHILEGLKICVENIDRVIEIIKKSKTDVDAQAKLCQTFSLSEIQAKAIVDMRLGRLTGLAIEKMNDELDQVNARIAEYRAILSSHEKLIELIIKELQEVKEAYGDKRRSEIRWDVMSSINNEDLIPQKEIVITLSSNNYIKRIDLEEYREQRRGGVGVSTVKTYQDDDIQDVVVANTHADLLIFTDEAKIYRVRGHEIPSGTKQSKGTPIVNIVPTIQKNEKVVKIICVTDYEESQSLITVTERGVIKKTNLKEYELIRKNGKYALSLLEDDHLIDVRVVDQDEEIFIAASNSRINRFNVADVREMGRVARGVGGIRLSDDDKVVSVSSSKDGAYIFSLGAKGYGKLSLVESYRKTKRNAKGVITLNEDKAGKLVYAAAVHGVEDLIIMTQSGIAIRISLRDINVIGRNAKGVKIINLKGRSDQIVGVAKIYDEDATDRELTKEEYIEVTKEIDIDLANE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Staphylococcus epidermidis (strain ATCC 12228)

Length

893 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

100.114 kDa

Sequence

MAELPQSRINERNITSEMRESFLDYAMSVIVSRALPDVRDGLKPVHRRILYGLNEQGMTPDKPYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLVNGAAGIAVGMATNIPPHNLTEVIDGVLSLSKNPDITINELMEDIQGPDFPTAGLVLGKSGIRRAYETGRGSIQMRSRAEIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALIHYLEHQKTVVRRRTEYNLKKARDRAHILEGLRIALDHIDEIITTIRESDTDKIAMASLQERFKLTERQAQAILDMRLRRLTGLERDKIESEYNELLEYIKELEEILADEEVLLQLVRDELTEIKERFGDERRTEIQLGGLEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRSQNRGGRGIQGMNTLDEDFVSQLVTMSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPIINAIELENDETISTMIAVKDLESEEDYLVFATKQGIVKRSSLSNFSRINKNGKIAINFKEDDELIAVRLTTGNEDILIGTAHASLIRFSESTLRPLGRTAAGVKGISLREGDTVVGLDVADSESEDEVLVVTENGYGKRTPVSEYRLSNRGGKGIKTATITERNGNIVCITTVTGEEDLMVVTNAGVIIRLDVHDISQNGRAAQGVRLMKLGDGQFVSTVAKVNEEDDNEENADEAQQSTTTETADVEEVVDDQTPGNAIHTEGDAEMESVESPENDDRIDIRQDFMDRVNEDIESASDNEEDSDE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Length

880 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

97.818 kDa

Sequence

MTDSIQSSITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDREGNTANKKYVKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQALLTDLDKETVNFSPNYDGELMIPDVLPTRIPALLANGSSGIAVGMATNIPPHNLNEVLNGCLAYIDKNEITIDELMQHIPGPDFPTAALINGRKGIEEAYRTGRGKVYVRARATVETNEKGREQIIVSELPYQVNKAKLVEKIAELIREKKIEGISNITDLSNKEGIRIEIDIKRDAVGEVVLNHLYSLTQMQVTFGINMVALDHGQPRLFNLKEIIEAFVLHRREVVTRRSIFELRKARERTHILEGLAVARSNIDEMIAIIRNSKNREEAATSISSRSWTLHSDIINLLDASARPDELEENLGIQGEQYYLSPAQVNAILELRLHRLTGIAFEEVIKEYEELLVKIADLLHILSSAERLMEVIREELEEVKAQFGDDRLTEITAASGDIDLEDLIAQEDVVVTLSHEGYVKYQPLTDYEAQRRGGKGKSATKMKEEDFIEKLLVANTHDTILCFSSRGRLYWLKVYQLPQASRGARGRPIVNILPLQENERITAILPVSAYEEDKFVVMATAGGIVKKIALTEFSRPRSNGIIALNLRDEDELIGVDITDGSNEIMLFSSQGRVVRFAENAVRAMGRLATGVRGIKLALTNDISDDESAVEIEDISDDNAEASLDLNIDKVVSLVVPKGEGAILTATQNGYGKRTQLSEYPTKSRNTKGVISIKVSERNGKVVAATQVEETDQIMLITDAGTLVRTRVSEVSIVGRNTQGVRLIRTADDEHVVSLERVCDADEDDSLEESSSEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Pectobacterium carotovorum

Length

878 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

97.589 kDa

Sequence

MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMSVLGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYETIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRMSKIAHELLADLEKETVDFVPNYDGTEQIPDVMPTRIPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAYIDDENISLEGLMEHIKGPDFPTAAIINGRRGIEEAYRTGRGKIYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRIEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNLYSQTQLQTSFGINMVALHQGQPKIMPLKDILVAFVRHRREVVTRRTIFELRKARDRAHILEGLAIALANIDPIIELIRRAASPAEAKASLIAQAWELGSVATMLERAGDDAARPEWLEPEFGIRDGRYYLTEQQAQAILDLRLQKLTGMEHEKLLDEYKELLAEIAELLYILNSPERLMEVIREELEAFKTQYSDERRTEITANTADINIEDLINQEDVVVTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGRHIFMATASGTVKKTALTEFSRHVSGIIAVNLNEGDELIGVDLTDGSDEAMLFSAEGKVVRFSEQAVRSMGRTATGVRGINLQGEDRVVSLIIPRGEGDILTVTQNGFGKRTAVSEYPTKSRATKGVISIKVSERNGKVVGAVQVDAADQIMMITDAGTLVRTRVSEVSIVGRNTQGVTLIRTAEDEHVVGLQRVAEPVEDEELDGVVKVEGEVAEDDDAIDDIDGDDDIAEDDE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Klebsiella oxytoca

Length

876 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

97.155 kDa

Sequence

MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMSKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSFGIAVGMATNIPPHNLTEVINGRLAYVEDEEISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYICARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGRVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKEIIAAFVRHRREVVTRRTILALRKARDRADILEALSIALANIDPIIELIRRAPTPAEAKAGLIARSWDLGNVSAMLEAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELVREQFGDARRTDITANSVDINIEDLITQEDVVVTLSHEGYVKYQPVNDYEAQRRGGKGKSAPRIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQVPEASRGARGRPIVNLLPLEANERYTAILPVREYEEGVNVFMATASGTVKKTPADEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDDVRAMGRTATGVRGIKLAGEDKVVSLIVPRGEGRILTATENGYRKRTAVAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRIRVSEVSIVGRNTQGVILIRTAEDENVVALQRVAEPVDDEELDAIDGSAAEGDEDIAPEADTDDDIAEDEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Escherichia coli (strain K12)

Length

875 amino acids

Function

Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

96.964 kDa

Sequence

MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)

Length

863 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

96.974 kDa

Sequence

MENIFSKDSDIELVDIENSIKSSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMQNDEAKSRTDFVKSARIVGAVIGRYHPHGDTAVYDALVRMAQDFSMRYPSITGQGNFGSIDGDSAAAMRYTEAKMSKLSHELLKDIDKDTVDFVPNYDGSESEPDVLPSRVPNLLLNGSSGIAVGMATNIPPHSLNELIDGLLYLLDNKDASLEEIMQFIKGPDFPTGGIIYGKKGIIEAYRTGRGRVKVRAKTHIEKKTNKDVIVIDELPYQTNKARLIEQIAELVKERQIEGISEVRDESNKEGIRVVIELKREAMSEIVLNNLFKSTTMESTFGVIMLAIHNKEPKIFSLLELLNLFLTHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIALIKNSSDNNTARDSLVAKFGLSELQANAILDMKLGRLTGLEREKIENELAELMKEIARLEEILKSETLLENLIRDELKEIRSKFDVPRITQIEDDYDDIDIEDLIPNENMVVTITHRGYIKRVPSKQYEKQKRGGKGKLAVTTYDDDFIESFFTANTHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLINLQAEEKIMAIIPTTDFDESKSLCFFTKNGIVKRTNLSEYQNIRSVGVRAINLDENDELVTAIIVQRDEDEIFATGGEENLENQEIENLDDENLENEESVSTQGKMLFAVTKKGMCIKFPLAKVREIGRVSRGVTAIKFKEKNDELVGAVVIENDEQEILSISAKGIGKRTNAGEYRLQSRGGKGVICMKLTEKTKDLISVVIVDETMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVENDEVVSIAKCPKEENDEDELSDENFGLDLQ

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Campylobacter fetus

Length

862 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.821 kDa

Sequence

MEENIFSSNQDIDAIDVEDSIKASYLDYSMSVIIGRALPDARDGLKPVHRRILYAMNDLGVGSRSPYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQNFSMRVPAVDGQGNFGSVDGDGAAAMRYTEARMTVLAEELLRDLDKDTVDFIPNYDDSLSEPDVLPARVPNLLLNGSSGIAVGMATNIPPHSLDELVNGLLTLLDDKEVGLEDIMTHIKGPDFPTGGIIFGKKGIIEAYKTGRGRIKLRAKTHIEKKPNKDVIVVDELPYQVNKAKLHADIADLVKEKLIDGISEVRDESDRDGIRLVIELKRDAMSEIVLNNLFKSTQMEVTFGVIMLAINNKEPKVFSLLELLKLFLNHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDAVINLIKTSADTNSARDGLMAKFGLSELQSNAILDMRLSKLTGLEREKLEAELKEILELIEKLDAILKSETLIENIIRDELLEIKSKFKCPRITDIVDDYDDIDVEDLIPNENMVVTITHRGYIKRVPSKSYEKQKRGGKGKVAVTTYDDDFIESFFTCMSHDTLMFVTDRGQLYWLKVYKIPEGSRTAKGKAVVNLISLQADEKIKAIIPTTDFDESKSLAFFTKNGIVKRTNLSEFKNIRSIGVKAINLDDNDELVTVVIANSEPDESYDDSFEDGEGVSNLQTISEDNSENSLESGKMLFAVTKKGMCIKFALNKVRQIGRVSRGVTAIRFKENLDEVVGAVVIENDSQEILSVSQKGIGKRTTADEYRLQSRGGKGVICMKLTPKTKDLVGVVMVDEEMDLMALTSSGKMIRVDMQSIRKAGRNTSGVIVVNVDGDEVVSIARCPKEESDDDDIVADDTQEQDME

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Campylobacter fetus

Length

862 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.821 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Length

860 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.073 kDa

Sequence

MTDSPDRLIATDLRNEMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMREPLIDGHGNFGSVDNDPPAAMRYTESRLRPLSTNSLLRDIEAETVDFIDNFDGSQQEPTVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGAIALIRNPEITEQELMQIIPGPDFPTGAQILGRSGIREAYLTGRGSITMRGVASIETMEHPGRPDRDAIIVTELPYQTNKAALIERIADLVNDKKIDGIADIRDESDRDGMRIVIELKRDAYARVVLNNLYKQTPIQSNFGANLLALVNGTPEVLTIKKFLTVFWEFRIETITRRTRYELRKAEERDHLLQGLLIALDNLDAVIRLIRGAADTASAKTELVEGFSLSEVQADAILQMQLRRLTALEADKITAEHDELQTKIADFQDILARRERVNAIIEEELEQIKAIHATPRRTVIVQEDGELIDTDLIANDQALILLTEQGYIKRMPASTFGTQNRATRGKAAAKIKDDDGVEHFLSCCDHDKVLFFSDRGVVYSLNAYQIPIASRTARGVPIVQMLPIPKDEKITSLVSVSEFDDDTYFIMLTKQGYIKKTALSAFSNIRANGLIAISLVEGDQLRWVRLAKAEDSVIIGSQKGMAIHFKADQDELRALGRATRGVKSMRLRSGDALISMDILPSQVVANIAVGSEDEPDEDLGGDTDAILEESDNPGPWLLGVTMKGFGKRVPIGQFRLQHRAGLGVKAIRFKSKDDQLVALHVVNADDELMIVTNRGIIIRQSVNDISPQSRSATGVRVQRLDADDAIAAVALVPPSGEEELAEMSESEES

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Haloferax lucentense (strain DSM 14919 / JCM 9276 / NCIMB 13854 / Aa 2.2)

Length

858 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.437 kDa

Sequence

MSSDAPDSFEPGAGIAAEVKNARIEDEMEQSYIDYAMSVIAGRALPDVRDGLKPVHRRILYAMHQAGVTSNSSHRKSSSIVGETMGDYHPHGDSAIYDTLARMAQDFSMRYPLVDGQGNFGSVDGDPPAAMRYTEARMSPIAEELLDDIDKDTVDFQSNYDDRKQEPTVLPSSFPNLLVNGSSGIAVGMSTNIPPHNLGEVVDATVELIENPDATVADLMEHIKGPDFPTGANIVGRNAVHKAYKTGRGRVRVRADYDVFEEEGRIVINELPYQENKARLIERIADDVNEGKIEGIRDIRDESDRDGIRVVIELKRGAMAEVVKNQLLDNHLESTFGVINLALVDGQPQVLTLKETLEHYLDHRRDVVRRRSEYELAEAEDRAHILDGRLKALDNIDDVVETIRNSESRDDAKAALRGEVEVEVDGEPLPTFDFSEEQANHIVSMQLGSLTSMEAAEIEAEYEDVQATIERLETILGDQSELDAVIESELLDIKDEYADDRRTSFVANTGEVTRADLIPEEDVVVVVSEDDYIKRMPVSRFRAQHRGGKGIIGTDLKEGDNVSSVFVTNTHDDLLCFTNHGQVYQLKAYQVPEMSRTARGKSAVNLLDFDDGEEITAVVNCDDLEDIEGYLTMVTRNGYIKRTGTDRFQNILSTGIIATKLDEGDELVDVEVTDGESDLVIGTERGMSIRFDEDEVRAMGRSARGVRGIKLEGDDVVAGVAAIDEAHHSWILTVTENGYGKRTDLDAYRTQSRNGKGLIDIKANERNGPVCAINTVGEGDHLVVMSDEGQILRTPVEDISTVGRNTMGVIVMDLDEGDAVASVDVIPAAMTTEAEELDDADSVEEDAETDAKADADDE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

Length

857 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.583 kDa

Sequence

MTTPEGDALAMRVEPVGLETEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPERGFYKCARVVGDVMGNYHPHGDSSIYDALVRLAQPWSMRMPLVDSNGNFGSPGNDPAAAMRYTECKMAPLSMEMVRDIDEETVDFTDNYDGRSQEPTVLPARFPNLLINGSAGIAVGMATNIPPHNLREVAAGAQWYLENYEASHEELLDALIERIKGPDFPTGALVVGRKGIEEAYRTGRGSITMRAVVEVEEIQNRQCLVVTELPYQTNPDNLAQKIADLVKDGKVGGIADVRDETSSRTGQRLVIVLKRDAVAKVVLNNLYKHTDLQSNFGANMLALVDGVPRTLSLDAFIRHWVNHQIEVIVRRTRFRLRKAEERAHILRGLLKALDAIDEVIALIRRSDTVEIARGGLMDLLEIDEIQANAILEMQLRRLAALERQKIVREHDELQAKITEYNEILASPVRQRGIVSEELTALVEKYGDDRKTKLIPYEGDMSIEDLIAEEDIVVTVTRGGYIKRTKTDDYRAQKRGGKGVRGTKLKEDDIVNHFFVSTTHHWLLFFTNKGRVYRAKAYELPDAGRDARGQHVANLLAFQPDETIAQIRAIRDYEAVPYLVLATKAGLVKKTPLKDYDSPRSGGVIAINLREQADGSDDELIGAELVSAEDDLLLISKKAQSIRFTASDDTLRPMGRATSGVKGMSFREGDELLSMNVVRAGTFVFTATDGGYAKRTSVDEYRVQGRGGLGIKAAKIVEDRGSLVGALVVEEHDEILAITLSGGVIRTRVNGVRETGRDTMGVQLINLGKRDAVVGIARNAEAGREAEEVDGDVAVDETAEGAATTGTDEGEAPSAE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)

Length

856 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.18 kDa

Sequence

MSSDAPERFDPETGIAAEVETARIEREMEQSYIDYAMSVIAGRALPDARDGLKPVHRRILYAMHQSGISARSAHRKSSSIVGETMGDYHPHGDSAIYNALARMAQDFSMRNPLVDGQGNFGSVDGDPPAAMRYTEARMSPIAEELLDNIEMDTVEFTANYDDRLSEPAVLPAAFPNLLVNGSSGIAVGMSTNIPPHNLGEVIDATIHLIHHPECTVEDLMNHVQGPDFPTGANIVGQNAIYKAYKTGRGRVRVRAEFDVQDDRIVITELPFQTNKARLVERIADNVNAGTIEGIRDLRDESDRDGIRVVVELKRGANPDIVKNQLLEHHLESTFGVINLALVDGQPQVLTLKETLHEYLEHRRTVVRRRSQYELDEKRDRAHILEGRLRALEQVDDVVDIIRNSTDRDNAKAALRGEHVVESDERGESLPTFDFSEDQANHIVAMQLGSLTSLESDEIEDEYESVQERIERLQTILNNPDELDAVVEDELATIRDKYADERRTRIIEDDGTVTHEDLIAQEDVVVVVTEDDYIKRMSLEDFRSQHRGGKGIIGTSLKDGDTVSSVYVANTHDYLLYFTSHGQVYQLKTYQIPEMSRTARGKSAVNLLELDDGEQITAVVNTAEMDIDDDEERYFTMVTQSGYIKRTSVNSFQNIRSTGIIAISLGADDKLIDVEVTDGNRDIILGTRKGMAIRFNEGDVRSVGRSARGVHGIKLEDTDAVAALAAVDDDQDDWVLTVTEHGYGKRTDIDRYRQQSRNGKGLIDIKTNERNGHVCEVETVGISDELFMMSRKGQILRTPVDDISTVGRNTMGVIVMDLEDTDTVASVDTHPRTDDSSEADSGDGESESENATATTPS

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium smegmatis

Length

854 amino acids

Function

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.925 kDa

Sequence

MTDTTLPPEGEAHDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSASSDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSRGIAVGMATNNPPHNLGELAEAVYWCLENYEADEEATCEAVMERVKGPDFPTSGLIVGTQGIEDTYKTGRGSIKMRGVVEIEEDSRGRTSIVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVVELKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVDHQLDVIVRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIARAGLIELLDIDDIQAQAILDMQLRRLAALERQKIVDDLAKIEAEIADLEDILAKPERQRGIVRDELKEIVDKHGDARRTRIVPADGQVSDEDLIAREDVVVTITETGYAKRTKTDLYHSQKRGGKGVQGAGLKQDDMVNHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATRNGLVKKSKLSDFDSNRSGGIVAINLREGDELVGAVLCSAEDDLLLVSANRQSIRFSATDEALRPMGRATSGVQGMRFNEDDRLLSLNVVRPDTYLLVATSGGYAKRTSIDEYSVQGRGGKGILTIQYDRKRGSLVGALIVDDDTELYAITSTGGVIRTAARQVRKAGRQTKGVRLMNLAEGDTLIAIARNGRGRGGRVDQRIRRGHRRVTRGVMETLRSRKVLGPS

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

Length

847 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.83 kDa

Sequence

MKEVAKEIIKIDIEDELKNSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMKVLNNDWNKTYKKSARIVGDVIGKYHPHGDTAVYDAIVRMAQPFSLRYVLIDGQGNFGSIDGDSAAAMRYTEIRMSKIAYELLNDLDKNTVSFFSNYDGTEKIPEVLPAKIPNLLINGSSGIAVGMATNIPPHNIKEVINGCLAFIDDQNITLKKLMEHIPGPDFPTAGLINGKRGIEKAYKTGKGKIYIRAKSIIEIQKKTKKKSIIIYELPYQVNKARVIKGIANLVKEKKIEGITTLRDESDKEGMRIVIEIKKETKAEIILNQLYSLTQLEISFGINMVALIHGQPKVMTLKEILNAFINHRRKIIMRRSLFELNKIRKKIHILEGLIISLDNIDLIINLIKKSSTLEEAKNKLKTYHWYSKHAQYTQILKKNAHSLTPYDKKLRPIDTQKFFLTPEQIQAILELRLQKLTHLEHKKLISEYKQLFKTSNNLENILKNNNILTKIMKDELIKIRDNFGDKRRTKINVNYSDINTSDLINKENVVITLSYSGYVKYQLLSSYEAQKRGGKGKLAVKTKEEDFIENLLVANTHDIILCFSSKGILYWMKVYQLPEASRHARGRPIVNLLPLSSNERITAILPISEYKDSINIFMATSKGMVKKTSLYEFKKPRTKGIIAINLKADDELIGVSLTNGNNTIMLFTAQGKAVHFSEILVRKTGRTAIGVQGIKIKKSDKVVSLVVPKKHGNILLITEHGYGKRTEIHEFPIKSRATQGTIAMKITKKNGIVIGTMQVVNQDQIIIITNAGTLVRTRVLEIGILGRNTQGVIIIRTSKKEKVVALQKANALHLNSV

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

Length

847 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

95.83 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))

Length

846 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.333 kDa

Sequence

MNPNDKNNIKELLNKTVVKEASITKELETSFMEYAMSVIVSRALPESRDGLKPVHRRVLYGAYTSGLTHDKPYRKSAQIVGHVMGKYHPHSDSAIYETMVRMAQPFSLRYMLIDGHGNFGSIDGDSAAAMRYTEARLSKISAEMLRNIDKDTVDFVDNYDASEQEPIVLPSLFPNLLANGSSGIAVGMATNIPPHNLSELIGGIKHLLVNENATIEELKEFIKGPDFPTAAEILGETGINEYFNTGRGSVSVRAKSEIEELANNKSNIVITQIPYMVNKANLINKIAELVKTEQIQGIADLRDESNREGIRIVIETKRDVIPEVLLNQLYKSTQLQTNFSVAMLALVNNQPKVLNLKEALQIYIDHQFDILLRKTNFELKKAKASAHIVEGLVIATNNIDDVIETIKNAKDNEDAKNTLMTKYELSDLQAKAILDMRLRSLSGLERENLQKELAKLKELIKDLEEILQNKERRIKIISDQLDEIDHKFGDERRTKICYGLNSTIDNEQLIPVETVVITRSSKGYLKRIPISAYKVQHRGGVGVKGMNTYEDDDVESLIVCSTHSDLLFFTNYGKVYRIRAHQVPLGSRISKGIPAINLISIEKDEKLMSLLSINDYDSGYFFFSTKKGLVKRVKASEFSRIQNNGKIAIKLTENDSLFKVIKTAGDEEIYIGVSSGLLVRFKEDVVRSMGRTAQGVIGVKFKNPNDEVIGLSSSHEGSLLLAVCEKGVGKMTDREEYRMTNRGSKGVITIKVTPKTGNIINTQLVNGNEELLMISSTGKIVRVPLAEVSEQGRNTSGVKLISLNEKETLQSVAIFDVEQDDSQQVGSDNPDTELSSDDSNQDQDKE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)

Length

843 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.818 kDa

Sequence

MTEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMNERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEELLKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILPGPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILDLSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQKRAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADLEDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGKGVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYLLMVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKLEDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIRVEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDSAES

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

842 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:8878580) to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.183 kDa

Sequence

MTDTTLPPEGEAHDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVYWCLENYEADEEATCEAVMERVKGPDFPTSGLIVGTQGIEDTYKTGRGSIKMRGVVEIEEDSRGRTSIVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVVELKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVDHQLDVIVRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIARAGLIELLDIDDIQAQAILDMQLRRLAALERQKIVDDLAKIEAEIADLEDILAKPERQRGIVRDELKEIVDKHGDARRTRIVPADGEVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDMVNHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATRNGLVKKSKLSDFDSNRSGGIVAINLREGDELVGAVLCSAEDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNEDDRLLSLNVVRPDTYLLVATSGGYAKRTSIDEYSVQGRGGKGILTIQYDRKRGSLVGALIVDDDTELYAITSTGGVIRTAARQVRKAGRQTKGVRLMNLAEGDTLIAIARNADEDEAAESISESDADTAESPEA

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970)

Length

840 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.252 kDa

Sequence

MALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKPVHRRALFAAFENGMTHDKPYKKSARWVGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVDGHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETVDFVPNYDASEQEPSVLPSGFPNLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEIYGDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQIEGISDLRDESSRDGIRIVIEVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVLNIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLVIAVNNIDEVIKIIKASGDDDIASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQVNIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYKNQRRGGVGVQGLKTYEDDDVEKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIPAINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRANLSDFESIRANGKIAITLKDGDKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLSSHGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIITTSGKVIRLSIKDISVIGRNTSGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Length

839 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.357 kDa

Sequence

MAKQQDQIDKIRQELAQSAIKNISLSSELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYTGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAGELLRDIDKDTVDFVANYDGEEQEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIQGLILLIDNPDCTINDLLGVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVSIEQLPTRAALVVTEIPYMVNKTSLIEKIVELVKAEEITGIADIRDESSREGIRLVIEVKRDTVPEVLLNQLFKSTRLQVRFPVNMLALVKGAPKLLNMKQALTVYLEHQLDVLIRKTQFNLKKYQERFHILSGLLIAALNIDEVIAIIKKSANNQVAMEALHERFGLDEIQARAVLDMRLRSLSVLEVNKLQTEQQELKALIEFCQQVLADKQLQLKLIKEQLTKINEQFGDPRRSEILYGISEDIDDEDLITQENVVITMSTNGYLKRIGVDAYNLQHRGGVGVKGLTTYTDDSISQLLVCSTHSDLLFFTDKGKVYRIRAHQIPPGFRTNKGIPAVNLIKIDKDEKICALISVNDYQNGYFFFCTKNGTIKRTSLSEFANILSIGKRAILFKENDVLFSVIRTSGQDDIFIGSTAGFVVRFHEDTVRPLSRAAMGVLGINLNQCEFVNGLSTSSNGSLLLSVGQNGIGKLTSIDKYRLTKRNAKGVKTLRVTAKTGPVVTTTTVFGNEDLLMISSAGKIVRISLEQLSEQRKNTSGVKLIKLKEKERLETVTIFKKEEAIKTTTATETDDVGSKQITQ

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

838 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.331 kDa

Sequence

MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

838 amino acids

Function

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.274 kDa

Sequence

MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Chlamydia trachomatis (strain D/UW-3/Cx)

Length

836 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

94.233 kDa

Sequence

MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDARDGLKPSQRRILYAMKQLNLTPGVKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANSQTSIEDILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKLRLRARMHVEENSDKQRENIILTEMPYNVNKSRLIEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVVINRLYKFTDVQVTFGANMLALDKNLPRTMNIHRMISAWIRHRMDVIQRRTRYELNKAEARAHILEGFLKALSCMDEVVKTIRESSNKEHAKQQLVELFSFSEAQALAILELRLYQLTGLEADKVQKEYSELLEKITYYRKVLAEEELVKDIIREELQELHKVHKTPRRTRIEMDAGDVRDIEDIISDESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGSDFLKAVYSASTKDYLLIFTNFGQCYWLKVWRLPEGERRAKGKPIINFLEGIRPGEQVAAVLNVKRFEQGEYLFLATKKGVVKKVSLDAFGSPRKKGIRALEIDDGDELIAARHIANDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEQDFVVSCQVVTEDQSVLVVCDNGFGKRSLVCDFRETNRGSVGVRSIVINQRNGDVLGAISVTDCDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLREGDTLVAMEKLSINTESVETEENLAASVQSGQDTIEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

Length

836 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.682 kDa

Sequence

MAKQQDQVDKIRENLDNSTVKSISLANELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYIGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAAELLKDIDKDTVDFIANYDGEEKEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIAGLIMLIDNPQCTFQELLTVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVEIEQLQTRSALVVTEIPYMVNKTTLIEKIVELVKAEEISGIADIRDESSREGIRLVIEVKRDTVPEVLLNQLFKSTRLQVRFPVNMLALVKGAPVLLNMKQALEVYLDHQIDVLVRKTKFVLNKQQERYHILSGLLIAALNIDEVVAIIKKSANNQEAINTLNTKFKLDEIQAKAVLDMRLRSLSVLEVNKLQTEQKELKDSIEFCKKVLADQKLQLKIIKEELQKINDQFGDERRSEILYDISEEIDDESLIKVENVVITMSTNGYLKRIGVDAYNLQHRGGVGVKGLTTYVDDSISQLLVCSTHSDLLFFTDKGKVYRIRAHQIPYGFRTNKGIPAVNLIKIEKDERICSLLSVNNYDDGYFFFCTKNGIVKRTSLNEFINILSNGKRAISFDDNDTLYSVIKTHGNDEIFIGSTNGFVVRFHENQLRVLSRTARGVFGISLNKGEFVNGLSTSSNGSLLLSVGQNGIGKLTSIDKYRLTKRNAKGVKTLRVTDRTGPVVTTTTVFGNEDLLMISSAGKIVRTSLQELSEQGKNTSGVKLIRLKDNERLERVTIFKEELEDKEMQLEDVGSKQITQ

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Chlamydia pneumoniae

Length

834 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.839 kDa

Sequence

MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSTYTTGRGKIKVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHKVARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKKGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDELIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)

Length

834 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.275 kDa

Sequence

MAVKKNKEDNSEERQYSTLTKDILKRVDHISIENELRESYLTYAMSVIVSRALPDVRDGLKPVHRRILYAMYDANLTHDKPYKKSAATVGEVLARYHPHGDAAVYGTMVRMAQDFSMRYLLVDGQGNFGSIDDDPPAAMRYTEARMTRFAEEMLNDIEKETVKFVPNFDDSRTEPSVLPATVPQLLVNGSMGIAIGMATNMPPHNLKEVVNAIVYYIDHQDAEIKDLMRYVQGPDFPTAGIIYGKEGIKEAYTTGKGRIKLRARLEVEETKRDREAIVVKELPYGVVKTTLHEKIADLVKQGKIEGVADIRDESSNRAGIRLIIELKKGVATQIVLNQLWKHTDLETTFGIINLALVNGEPKVLNLKELIKYFVDHRVEVITKRTEYDLNQAKAKAHILEGLLIAQANIEEVIRIIRESENTDAARTTLMNRFKLSEKQAQAILDMPLKRLTALEKLKIEQELQQLREFIAYCEDLLAHPEKILAVIKDELKKISEKYGDDRRSEIIGKTNDTEIDEEDLIHDEDVAVSITTQGFIKRVPASSYRTQGRGGVGVQGGKSQGEHYIEHLFVASTKDYLFIFTDRGKAFWMKVHEIPALSKISQGKSIKFILNLAPEEKITSYFTVSEFDPKQSIIMVTKMGTIKKMELKHLENAKKRGILALTLENNDELVAVSPVQTGDDFIMTTAAGLALRITEEKIRKMGRAAAGVKGISLDDDDICVSGNAIHKGESLIVITENGIGKRLSSKQFNVKGRGGKGQIYIKPDNKTGNVVSVKTVGDKDEIMVVTTDDMTIKIKADSIPELGRNAKGVKIVNISDGARVSDLAVVPADNEEKK

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)

Length

834 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.275 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Chlamydia muridarum (strain MoPn / Nigg)

Length

833 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.884 kDa

Sequence

MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPHGEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKLRLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMDVIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRESSNKEHAKQQLVELFGFSEAQSLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHKTPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGSDFLKAVYSASTKDYLLIFTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQVAAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGIRALEIDDGDELIAARHIVNDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCDNGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLREGDTLVAMEKLSVNTESGETEESVSIQVGHAVEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

Length

833 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.873 kDa

Sequence

MAEQDQSRVKEINISQEMKTSFMDYAMSVIVSRALPDVRDGMKPVHRRILYAMNELGMTSDKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSYRYMLVDGHGNFGSIDGDAAAAMRYTEARMSKISMELVRDINKDTIDYQDNYDGSEKEPVVMPSRFPNLLVNGASGIAVGMATNIPPHQLGEVIDGVLALSKNPDISVPELMEHIPGPDFPTGAEILGRSGIRKAYQTGRGSITLRAKTEIEEHHGKQRIIVHEIPYQVNKAKLIEKIAELVRDKKIDGITDLRDESDRNGMRIVIEVRKDANANVLLNNLYKQTALQTSFGINLLALVEGQPKVLNLKECLEHYLAHQVIVIRRRTAFELRKAEARAHILEGLRIALDHLDEVISLIRSSQTTEIARNGLMERFELSYEQAQAILDMRLQRLTGLERDKIEAEYKELIERIAELKAILADHEKVLDIIREELLELKEKYNDERKTAISASEDMFEDEDLIPRQNVVITLTHHGYIKRLPISTYRSQKRGGRGIQGMGTNEDDFVQHLFTTNSHHTILFFTNKGKVYRLKGYEIPELGRTAKGIPIINLLQIEQDEYISTIIPIEEFTEDHYLFFMTKDGIAKRTQLSSFANIRRGGLFAINLREGDELHGVRLTNGDKEVIVGTRQGMAIRFHETDVRLMGRTATGVKGISLTGDDHVVGMDIVEDGQDVLIVTEKGFGKRTPIADYRIQTRGGKGIKTCNITEKNGPLVSLKVVSVDHDLMIITASGIIIRLHVKDISVTGRITQGVTLIRVAEGEEVATVARVDIEDDELDEDESIEEERDDRSEVEQGENE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

Length

833 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.873 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)

Length

830 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.612 kDa

Sequence

MLNEGKVLPVDISSEMKKCYIDYAMSVIVSRALPDVRDGLKPVHRRILYSMHELGLTPEKGYRKCARIVGDVLGKYHPHGDSSVYGALVRLAQDFNLRYTVVDGHGNFGSVDGDSAAAMRYTEAKMNKIALEMVRDIGKNTVDFIPNFDGEEKEPVVLPSRFPNLLVNGSAGIAVGMATNIPPHNLGEVIDGITMLIDNPEATILELMAQIKGPDFPTAGIIMGKSGIRAAYETGRGKITVRAKSEIEVEDNGKQKIIITEIPYQVNKARLVESIADLVKDKRIVGISDLRDESDRDGMRIVIEIKKDANSNIILNQLYKHTRLQDTFGINMLALVDNRPEVLNLKQILQHYIKFQEQVIRRRTEFDLEKASARAHILEGLKIALDHIDEVISLIRGSKTAQEAKLGLMDKFGLSEKQAQAILDLKLQRLTGLEREKIEDEYNELMKTIAELKSILADENKILAIIRDELNEIKAKYGDERKTAIERAENDIDIEDLIQEENVVITLTHAGYIKRINADTYTSQKRGGRGIQAMTTKEDDFVENIFITSTHNNILFFTNKGRMYKLKAYQIPEAGRAAKGTNVVNLLQLDPNEKIQAVISIKEFDEESFLVMCTKKGIIKKTVVGMYKNIRKSGLIAINLNDDDELVSVRITKGDDDIIIVTNKGLAIRFNEVDVRPLGRNALGVKGITLKEDDFVVGMEVPNQESDVLVVSENGFGKRTHVGEYKCQHRGGKGLITYKVSDKTGKLVGVRMVEDGDELMLINNLGIAIRINVSDISTTSRNAMGVTLMRNNGDEKVLALAKINKDDSEQLEDSEEVSEVHDAEENNSEE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

Length

830 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.879 kDa

Sequence

MKDPSREIIQVNIEEELKSSYLDYSMSVIVGRALPDVRDGLKPVHRRILFAMYILNNDWNKAYKKSARIVGDVIGKYHPHGDSAVYDAIVRMAQKFSLRYMLIDGQGNFGSVDGDSAAAMRYTEVRMSKIAHELLNDLEKNTVEFLPNYDGTEYIPEILPAKIPNLLINGSSGIAVGMATNIPPHNLNEVINGCLAYIDNNDITLEELIKHIPGPDFPTAAIINGKSGIEEAYRTGKGKIYIRAQNQIEKNKKNKKESIVFNEIPYQVNKSRLIEKIAELVKEKRIDGITALRDESDKDGMRIVIEIKREAIAEVILNQLYSLTQLQISFGINMVALCQGQPKTLSLKEILKNFLSHRQEIIIRRSLFELNKVRNRIHILEGLNMALININAIIEIIKNSVNSIDAKKIIIQKNWKSEKINYLAKKHEYYFSEKQAQAILDLRLHKITNLEQEKIIMEHNDLIKKTKELKEILENPKKMFEVIKSELLSIQNNFSDKRRTKITENHSDINMEDLINQEDVVVTLSHSGYVKYQPLSDYNAQRRGGKGKSAAKIKEEDFIESLVIANTHDTILCFSSRGILYWMKVYQLPESSRHARGRPIVNLLPLSPKERITAILPVHKYQDNLNIFMTTAHGIVKKSSLSQFKKPRFAGIIAINLHANDELIGVALTDGNNNIMLFTQNGKVVQFLENSVRTMGRTASGVKGIKIKKNDKVVSLIVPKNKGSILIATKNGYGKRTKISDFPIKSRATQGVISIKITKKNGKIIGAIQVIEKDQIMMITDAGTLVRIRVSEVGVLKRNTQGVILIRTSKNEKVVALQKIVDPMIEKIDL

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

Length

830 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.879 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Helicobacter pylori (strain J99 / ATCC 700824)

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.651 kDa

Sequence

MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLGNPNAELDKILEFVKGPDFPTGGIIYGKAGIVEAYKTGRGRVKVRAKVHVEKTKNKEIIVLGEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSPSPEAAKNALIERFSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNEVVKTELLEVKEQFSSPRRTEIQESYESIDTEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPNEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFGGNRSYSGIRAIVLDEGDELVGAKVVDKNAKHLLIASYLGMFIKFPLEDVREIGRTTRGVMGIRLNENDFVVGAVVISDDSNKLLSVSENGLGKQTLAEAYREQSRGGKGVIGMKLTQKTGNLVSVISVDDENLNLMILTASAKMIRVSIKDIRETGRNASGVKLINTADKVVYVNSCPKEEEPENLETSSVQNLFE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pyogenes serotype M1

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.704 kDa

Sequence

MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELISTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.69 kDa

Sequence

MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.718 kDa

Sequence

MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIRDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pyogenes serotype M18 (strain MGAS8232)

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.744 kDa

Sequence

MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISYQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIRDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pyogenes serotype M3 (strain SSI-1)

Length

828 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.69 kDa

Sequence

MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Helicobacter pylori (strain ATCC 700392 / 26695)

Length

827 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.5 kDa

Sequence

MQDNSVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRMDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTGRGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLHLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSQSPEAAKNALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNGVVKTELLEVKEQFSSPRRTEIQESYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFESNRSCGIRAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEEVREIGRTTRGVIGIKLNENDFVVGAVVISDDGNKLLSVSENGLGKQTLAEAYRGQSRGGKGVIGMKLTQKTGNLVGVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTADKVMYVNSCPKEEEPENLETSSAQNLFE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

Length

825 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.365 kDa

Sequence

MKHLAREIVQVDIEKELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMHVLSNYWNKAYKKSARVVGDVIGKYHPHGDSAVYDSIVRMAQNFSLRYMLIDGQGNFGSIDGDAAAAMRYTEVRMSKISQELLADLEKNTVEFIPNYDGTEHIPEILPSKIPNLLINGSSGIAVGMATNIPPHNLNEVIDGCLAYIKDDNITLRELIQHIPGPDFPTAGIINGKKGIEEAYRTGKGKIYIRARNKIEKNKKNKKESIIFYEIPYQVNKSRLIEKIAELVKEKRIDGITALRDESDKDGMRIVVEIKKEAMSEIILNQLYSLTQLQISFGINMVALCQGQPKTLSLKEILKHFLSHREEIVTRRSIFELDKTCKRSHILEGLSIALININCIIDLIKKAKSSLEAKELIIKKTWIYKNSEKINQKDHDYHFTEEQVQAILDLRLHKLTSLEKNKLVLEYDCLTKKIKELKKILKSRDRMREVIRDELVSIKNNFGDQRRTEITENNPDISIEDLINQEDVVVTLSHSGYVKYQPLSDYNAQKRGGKGKSAAKIKEEDFIESLVVTNTHDTILCFSSRGILYWMKVYQLPESSRHAKGRPIVNLLPLSNKERITAILPIHEFKDNLNIFMATAQGIVKKSSLKEFKKPRIAGIIAINLRANDELIGVSLTNGKNNIMLFTQNGKVVQFLENSVRTMGRTASGVRGIKISKNDKVVSLIVPYKKESILIATNNGYGKRTKITDFPIKSRATQGVISIKITKKNGKIIGAIQVVEKDQIMMITNAGTLVRIRASEIGVLKRNTQGVILIRTSKNEKVVALQRIVEPI

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

Length

825 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

93.365 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Length

822 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.053 kDa

Sequence

MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMIGQVLSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Length

822 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.039 kDa

Sequence

MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQVLSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Bacillus subtilis (strain 168)

Length

821 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.099 kDa

Sequence

MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVVTLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKRTSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMGRTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKTAKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEEHVATVALVEKNEEDENEEEQEEV

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Bacillus subtilis (strain 168)

Length

821 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

92.099 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Lawsonia intracellularis (strain PHE/MN1-00)

Length

820 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.735 kDa

Sequence

MSQTEHHISIEQEMRKSYLEYSLSVIIGRAIPDVRDGLKPVHRRILFAQQELGNSYTRPPKKCARIVGDVIGKYHPHGDSAVYDALVRMAQDFSMRDPLEEGQGNFGSIDGDAPAAMRYTEVRMSRLASEFLSDIDKETVDFRPNYDNSLEEPIVLPTKVPNLLLNGSSGIAVGMATNIPPHNLGELCNALLKIIDDPDVPIDNLLNIIHGPDFPTGGFIYVGQGLYDAYTKGRGTVKVRGKVEIEERKKGAQSIVIREIPFGLNKSSLVEKIAILVNERKIDGIADLRDESDRKGIRVVIELKKGVIPEIIINALYKFTPLETSFGINMLAVVDNRPQLLTIKSALTYFLDHRREVIVRRTRFELNKAEARLHILIGLIHALDHIDEVVNLIRSSSTPAEAKIRLIERFSLSEIQAQSILDMRLQRLTGLEREKLEEEMHELQTKIAWYESILGDTKILWGVIRDEVTGIKEMYTTPRRTEVIRETLTNIEIEDLIPDDDVVITLSRRGYIKRTNLAIYQQQRRGGKGVAGLHTSEDDFVQEFITTTNHQFLLLFTNKGRMHQLKVHQVPEGSRTAKGTHIANIVPLEKEEWVTTILTVREFSDNKFFLFATRKGMVKRSSASYYARSRRTGLLAVGLREDDELIMVKEVTNNDFIVLATAEGFAIRFSCEDVRNMGRGAAGVKGIALRPGDSVVACLILQEKQDTPAIMTVSNLGYGKRTSIDLYRVQTRGGKGIINFKVTQKTGLVIGAKPVSDDNALVLLTSTNKIIRMSVDEVRSAGRATMGVRLVKLDDGAYVVGFDTVDGTVDDSCDDATINT

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Aminobacterium colombiense (strain DSM 12261 / ALA-1)

Length

817 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.065 kDa

Sequence

MEEKKGEPLFGKVVPLPLVEEIKHSYLDYAMSVIVGRALPDARDGLKPVQRRILYAMMELGLRHNTAYKKSARVVGETMGKYHPHGDSAIYDTMVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLYEIGELMLADIDQDTVDWGPNFDESLQEPLCLPAMLPNLLINGSSGIAVGMATNIPPHNLVEVVDALCYLIDTEPEQVDIGEILFRMPGPDFPTGGLILGRDGIIDAYRTGRGKITMRGRTHIEEGKRGKTFIVITEIPYMVNKTNLIETIAKNVQDKTIDGVMDLRDESDREGLRIVIEVNRDTDPNLVLRQLYRRTQLQSTFGVINLALIDGYPKELSIEEMLNIFLNHRRSVVRRRTQFRLEKAEARAHIVEGLVKALDIIDEVIALIRGSATTEEAKEGLISKLDFSEAQAQAILEMRLQRLTGLEREKLEAELAQLLSDIERYQTILGNPKVLDSVIKEELLEVKRRFGNERKTEIIDAVEDVSIEDLIPESDIVVVLSRDGYLRRKDLQEYTLQGRGGKGRKGTALQEEDEVALVAVTSTHRDIYLFTSKGRVLALKGYVIPESKTGRGKLINRFVALEEGERVVTMHGRAVDGAKYAFFITLRGTAKRLDLSELENLTRAGRRVMGLDEGDEISQIVLTSGDDHLLIVTAQGQALRTHESEFRPMGRTARGVRGIRLRKNDYVIGCDVVANGRWPLLLSENGFGKRTKYDEFSLRHRGGSGVIVMNLSDRTGLIVGCWSVAEGDEIVAITSRGRMIRLAVSESPVLGRTAMGSIMMRLDEGDTVATASVVSTEDGEDD

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Aminobacterium colombiense (strain DSM 12261 / ALA-1)

Length

817 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.065 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Dehalogenimonas lykanthroporepellens (strain ATCC BAA-1523 / JCM 15061 / BL-DC-9)

Length

814 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

90.33 kDa

Sequence

MVIGNTRPINIEDEMKNSYMDYAMSVIVSRALPDVRDGLKPVHRRILYAMSDLGMHYNTSYKKSARIVGEVLGKYHPHGDSSVYDAMVRMAQNFSLRYMLVDGQGNFGSVDGDPPAAMRYTEARLTRLAGELLVDIDKDTVEFMPNFDDSLKEPTVLPSRLPVLLMNGASGIAVGMATNIPPHNLTELCDAISYLIDNPECGLEDLMQFVKGPDFPTGGLILGRDGIKSAYATGHGKVVVRARAHVADVAETGARRQIIISELPYQVNKADLVKRIAMLSRERKINGIAEVRDESDRQGLRVVIELKRDGEPQQILNNLYKHTNLQTSFFVNMLALVNNRPVVLNLKEALNHYVAFRQEIITRRSKFELKAARARAHILEGLKIALDNLDAIINLIRHAENADTARRELMSRFELSQLQAQAILDLQLRRLANLERQKILGEYADILKQISYLEDLLANPRKVLSLVKDDLAEVKARYGDARRTEIQSQGVIEFREEDLIPHQSMVVTLTERGFIKRVPTEVYRLQHRAGRGKSIIKTREADSVRFIMVADTHDSVLLFTNRGKIFSIKCHEIPCDLLRTAKGIAIINLVPLAENERITSMIAVSRFDEETSLIMATSGGECKRTKLSDFAAVRSSGLLAMDLPKNDELIGAVIAGADENIILITHNGRSIHFPVADLRVSQRASGGVRGITLEGDDRVAGLDVARPGHFVLVVTTGGYGKLTAVEEYPLQRRAGSGVLTFKVVDKTGKVAAGKVVDREHQVMIATAEGVVIRTPVGTEDQEKGIIVMGRSTQGVIVIRPDENDRVVNFATMVE

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Treponema pallidum (strain Nichols)

Length

813 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

89.926 kDa

Sequence

MEEISTPEGGVLVPISIETEVKRAYIDYSMSVIVSRALPDVRDGLKPVHRRILYAMEEKGLRFSGPTRKCAKIVGDVLGSFHPHGDASVYDALVRLGQDFSLRYPVIHPQGNFGTIGGDPPAAYRYTEAKMARIAESMVEDIKKETVSFVPNFDDSDVEPTVLPGRFPFLLANGSSGIAVGMTTNMPPHNLREIAAAISAYIENPNLSIQELCDCINGPDFPTGGIIFGKNGIRQSYETGRGKIVVRARFTIETDSKGRDTIIFTEVPYQVNTTMLVMRIGELARAKVIEGIANVNDETSDRTGLRIVVELKKGTPAQVVLNHLFAKTPLQSSFNVINLALVEGRPRMLTLKDLVRYFVEHRVDVVTRRAHFELRKAQERIHLVRALIRALDAIDKIITLIRHSQNTELAKQRLREQFDFDNVQAQAIVDMQMKRLTGLEVESLRTELKDLTELISSLEELLTSPQKVLGVVKKETRDIADMFGDDRRTDIVSNEIEYLDVEDFIQKEEMVILISHLGYIKRVPVSAYRNQNRGGKGSSSANLAAHDFISQIFTASTHDYVMFVTSRGRAYWLKVYGIPESGRANRGSHIKSLLMVATDEEITAIVSLREFSNKSYVFMATARGVVKKVTTDNFVNAKTRGIIALKLSGGDTLVSAVLVQDEDEVMLITRQGKALRMSGREVREMGRNSSGVIGIKLTSEDLVAGVLRVSEQRKVLIMTENGYGKRVSFSEFSVHGRGTAGQKIYTQTDRKGAIIGALAVLDTDECMCITGQGKTIRVDVCAISVLGRGAQGVRVLDIEPSDLVVGLSCVMQG

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)

Length

812 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

90.484 kDa

Sequence

MPEEIISRSINDEMITSYMLYSMSVIVGRAIPDVRDGLKPVQRKILFGMLELGLRHNQSYKKSARIVGEVMGKFHPHGDMAIYDALVRMAQPFSMRYPLIQGQGNFGSIDRDPPAAMRYTEARMQRLAEELLADIDKNTVKMIPNFDGSLIEPEVLPAKAPNLLMNGASGIAVGMMTNIPPHNLSELVEALTALIDNPDATIEELMEYVKGPDFPTGGIIMGRDGIKKMYETGRGRMVVRGVAEIEEAKGGTRIVISEIPYGVSKADLIQQIANVAQNVRDIQVRNVRDESDKRGLRVVIELKRGADPNVVLNLLYKHTQLQTTFGAHMLVIDEKKRPKLMNLKEIFQAFIKHRYEVVKRRTEYELEQASKKAHILEGLTKASRAIDTVVDIIRNSKNIQEASVNLQETLEITPEQSQAILEMRLGKLTALEIDKLVTEYAELVEKIKEYREILSDDKNIYQIIKKELQELEAQYGDARRTKISIDGNTDFNVEDVIPDDEVVVTVTKKGYIKATPLEDYRKQGRGGKGIRGVKTTDADFVTNVVSTTRLSKTVVITSKGKAYFINNYELECTSRSSRGKLLANYVKIEPDETVQAVLSVKREEVANKHLIITTRKGKIKRTPFEAFINSRTSGIKAITLNEGDSVVDAGISTSEEETIIISTRKGMVIRFPISQIRPMGRTAAGVKAMALRGDDEVVSATIVLPVDERYLFTATERGVGKRTPLSEYRPQHRAGMGVKNIYGLERTGYVVGSLVVTNEDEIIVITKNGMSIRIPAADIRPTGRVTKGVKVVELRDDDTVASLAVVVDQAEV

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)

Length

811 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

89.874 kDa

Sequence

MTGIHPVDITSEVKTNFINYAMNVIVDRALPDVRDGLKPVQRRIMYAMLLEGLYSNQKHAKSASVVGEVMKKYHPHGDSSIYDAMVRLAQWWNMRYPMVHPQGNFGSIDGDPPAAMRYTEARMTKVAEELIADLEKETVDLKPNYDETTEEPSVLPAAVPNLLINGATGIAVGMATNIPPHNLTEICNGLLAMIDDPNLTLDGLMEHVTGPDFPTGGRITKTGIREAYATGHSGLKVRGKARIEEKNGRNQIIISEIPYQVNKTNLIQTISAMYKAGKIPDISALRDESDRKDPVRIVVELKRGAIPTLVLNQLYKYTQLQTTYTVINLSIVGGEPRVLPLLNTMQYFLDHRADVVTRRTRYDLRKAEERAHVLEGLLKALDHIDEVISLIRGSNTGAEARDALMVRFGLTEIQSQAILDMRLQRLVGLEREKLQAEFDELQKTIEYLRSILGDEKLLWREIKKEIRAIRDNYGDERRSTITELEEDIGKEDLIAVEDMVITMTKAGYLKRTKLDAYRAQGRGGRGSSGGKLREEDVNTRVFVGSTHDYLLFFTDQGRVFHEKIYDLPEAGRDAKGTHIRNLLPSLREDENIASVLSVGGFDEPGCFIFATRKGVVKKTLITEYGNITSAGLIAINLQPGDELIGVGIVNDIDHVVLATRNGKAMRFESDEVRATGRATQGVIGIRLREGEDDAVVSMALVPGGDEASELLAVSECGLGKRTPVGDYPAKGRGGMGVITLDVTEKTGKLVTLARVAGNEELMVLTEKGTVIRTRVEEVRVTGRNAQGVKVINIAERDSVISAFPIRREDEL

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)

Length

810 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state (PubMed:15897198). Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.379 kDa

Sequence

MAVGENKEQILNVRIEDEIKTSYLNYAMSVIVSRALPDVRDGLKPVHRRILYSMYEMGLRSDKAFKKAGRIVGDVLGKYHPHGDQSIYDALVRLAQDFSLRYPVIRGQGNFGSIDGDPPAAMRYTEAKMEKITEYIVKDIDKETVNFKSNYDDSLSEPEIMPSSFPFLLVNGSSGIAVGMATNMAPHNLREICDAIVYMLDNENASIFDLLKIVKGPDFPTFGEIVYNDNLIKAYKTGKGSVVIRARYHIEERAEDRNAIIVTEIPYTVNKSALLMKVALLAKEEKLEGLLDIRDESDREGIRIVLEVKRGFDPHVIMNLLYEYTEFKKHFSINNLALVNGIPKQLNLEELLFEFIEHRKNIIERRIEFDLRKAKEKAHVLEGLNIALNNIDEVIKIIKSSKLAKDARERLVSNFGLSEIQANSVLDMRLQKLTALEIFKLEEELNILLSLIKDYEDILLNPVRIINIIREETINLGLKFGDERRTKIIYDEEVLKTSMSDLMQKENIVVMLTKKGFLKRLSQNEYKLQGTGGKGLSSFDLNDGDEIVIALCVNTHDYLFMISNEGKLYLINAYEIKDSSRASKGQNISELINLGDQEEILTIKNSKDLTDDAYLLLTTASGKIARFESTDFKAVKSRGVIVIKLNDKDFVTSAEIVFKDEKVICLSKKGSAFIFNSRDVRLTNRGTQGVCGMKLKEGDLFVKVLSVKENPYLLIVSENGYGKRLNMSKISELKRGATGYTSYKKSDKKAGSVVDAIAVSEDDEILLVSKRSKALRTVAGKVSEQGKDARGIQVLFLDNDSLVSVSKFIK

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Borrelia hermsii (strain HS1 / DAH)

Length

810 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.51 kDa

Sequence

MVTEEDKEQILNIKIEDEVKTSYLNYAMSVIVSRALPDVRDGLKPVHRRILYSMHEMGLRADKAFKKAGRIVGDVLGKYHPHGDQSIYEALVRLAQDFSLRYPIVIGQGNFGSIDGDPPAAMRYTEARMARVAEELVRDIDKQTVDFRANYDDSLLEPEVLPAAFPFLLVNGSSGIAVGMATNMAPHNLKEICDAIVYMLDHDSVSVYDLIEIVKGPDFPTYAEIIYNESLIKAYTTGKGSVVIRARYHIEEKFEDHIAIIITQIPYAVNKSSLLMKIAFLIKEEKLEGVSDIRDESDREGIRIVLEIKKGFDPHVVMNLLYEYTELRKNFSINNLALVNGIPKQLNLKELISAFIEHRKEIVRRRVEFDLKRAREKAHILEGLNIALRNIDRVIEIIRFARLVKDAKECIIKEFNLSEIQANSILDMKLQKLTSIETEKLEEEFKILLALIKDYEDILNSPERVVNIVREEIINLSLKFGDERRTKIIYDEEVLKTSMSDLMQRENVIVILTKQGFIKRILQDEYKLQGIGGKGLGSFDLQDRDQVNITLCVNTHDFLFMISNEGKLYVINAYGIKDTSRTSKGQNVRELINLGETEEILAIKNCNELSVDNYLLITTANGKIARIETEGFKTVKARGVIVIKLDDNDFVTSAEIVSKNEKIICISKKGNAFAFNSDNIRLTHRGTQGVSGMKVREGDVLIKALAVKQGSHLLVVSENGYGKRLEISKVTDLKRGATGYTCYKKSDEKAGEVVDAITVVQDDEILLVSKGAKVLRTLVDKISEQGKDARGMQVLSLDEDKLISVSKFIK

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)

Length

810 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state (PubMed:15897198). Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.379 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Borrelia hermsii (strain HS1 / DAH)

Length

810 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

91.51 kDa

Sequence

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Length

805 amino acids

Function

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

89.12 kDa

Sequence

MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKVRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLITEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPLSEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFVVEEEK

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Length

804 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

90.448 kDa

Sequence

MPEILINKPVEDELVESYLLYSMSVIVGRAIPDVRDGLKPVQRRILYGMYELGLKHNSPTKKSARIVGEVMGKYHPHGDAPVYDALVRMAQPFTMRYPLIEGQGNFGSIDRDPPAAMRYTEARLTRLAEEMLEDIEKNTVNMIDNFDGTLKEPEVLPSKVPNLIINGASGIAVGMATNIPPHNLSETVDALIYLIDHPEATVEELMQFIKGPDFPTGAVVVNASELKKVYEEGRGRIIVRGKVHVEDGKRVKRIVITEIPYGVSKAGLIEQIAKIAKDDESLPIRNIRDESDKRGMRIVIEIPKDANEEVIINNLYKRTALQDYFNVQMLVIDKHKRPRLMNLKGLMEAFLEHRFEVIRRRARYEYEQYTRRAHVVEGLLKAARAIGVVVDIVRNSKDVESARQSLMETLEITEEQAKAILDMRLSRLTSLEIENLQNEYSDLVRKISEVKEILEKDEKVKEIMKKEFLYLKQQYGDPRRTEVTDQSIEYNEEELIVEEDVVITLSHKGYLKSTPLNSYRSQKRGGKGITVSKLSEDDEVEFVVVAKNTSSTLFITNLGRAYVLKNYQLETTGRNTRGRHITAFLNLEDTEKIVALASLNGEGRDLVIATKSGKIKRTALKEFENATSNRGVRAIKIEPGDEIVSARVVNSEKETLIVATKMGMAIRFPVSDVRRMGRNAAGVQAIKLQPGDEVVSVDVIPPGEEGEILTVTEKGFGKRTPVQLYRIQRRGGTGLRNISDVNKTGYVVAVRYVRGDEEIVVVTRNGMMIRFPVSEIGVIGRVTKGVKLIELGDDTISKVAVVKD

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

Type 2 topoisomerase subunit A

Organism

Aquifex aeolicus (strain VF5)

Length

769 amino acids

Function

A type II topoisomerase. Despite its similarity to DNA gyrase, this enzyme is not able to supercoil DNA, and instead acts like topoisomerase IV. Relaxes both positively and negatively supercoiled DNA in an ATP-dependent fashion, decatenates interlocked circles. This the first bacteria shown to not contain DNA gyrase, although it has 2 copies of a reverse gyrase that introduces positive supercoils. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (PubMed:21076033).

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

86.996 kDa

Sequence

MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIKVKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYKYTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKDASEARNYLMEEFGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDKRRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRVYWIAGSQALQGSKVSLKSREEKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREVPPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVELLITTKNGKAFYDKINQKDIPLSTKKSIPRTRWKLEDDEIIKVVIKKSE

Protein

Type 2 topoisomerase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium flavescens

Length

554 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

60.953 kDa

Fragment

single

Sequence

RGIFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVTGDALVRLPFGQSVRLRDVVAGARSSSDNAIDLKVLNRHGDPVVADKLFHSGEHETYTVRTAEGYEVTGTANHPLLCLVDVGGVPTLLWKLTEEIRPGDHVVLQRTPPTEFGPADWQDAFEALHLGAFISEGFVSENRAGFNNLDREFFNAVLTAYDTIVGGPRYVSSRTIASDSLLHELDVHNLTALKKSRLGELVGQRSADKAVPEWLWKAPAVVKRVFLQALFEGDGSCSALPRNTIQVSYSTRSGRLAKDIQQMLLEFGVISRRYVHATGEHKVVLTSRAQAELFAAQIGFGGIKQAKLQGLLDALPQAAAGRDGDYVPGLAQFVRKHSGSRWVDKDWLNRHNIDRLSRWQRDGAEILGRIADPDVRAIAQELTDGRFYYARVASVTDSGVQPVYSLRVDTDDHSFITNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium gordonae

Length

550 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

60.537 kDa

Fragment

single

Sequence

FRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCLTGDALVRLPFGQSMRIGDVAPGARTNSDNAGELKVLDRHGDPVFADRLFHSGDHQTFRVQTAEGYEVTGTSNHPVLCLVNLAGVPTLLWMLIEEIRPDDYVVLQRAPPVESGPANWRDAMEALLLGAFISEGFMSESRAGFNNVDRDYFNAVVAAYDAVVGGKRYVAQRTIASGSVLNELDIHDVSALKGTRLGVLCGQRSADKSVPEWLWQSPAAVKRVFLQALFEGDGSCSALPRNTIQVSYSTRSRQLAIDVQQMLLEFGVISRRYRHAVGEYKVVITNRAQAELFATQIGFGGAKQSKLTRILGSLPPCAGMDTNHVPGLAAFIRSHCDSEWVDKEWLRKHNIDRLSRWRRDGAEILSRIANPDVRAIATDLTDGRFYYAQVTSVTEAGVQPVYSLRVDSEDHAFLTNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium kansasii

Length

549 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

61.051 kDa

Fragment

single

Sequence

RPARSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNVPPAAMRYCVTGDALVRLPFGQSMRIADVVPGARPNSDNAVELKVLDRHGNPVAADRLFHSGDHQTYMVRTAEGYEVTGTANHPLLCLVDVGGVPTLLWKLIEEIHPDDYVALQRTPPMELGPADWHDTMEALLLGAFISEGCVSETRAGFANLDRDYFTMVARAYDAVVGDKRDVYQQTIASGSLQHTLYTQNVTALKQSRLWQILGMRSADTYVPEWMWHSPAAVKRVFLQALFEGDGSCSRRPHNTIQISYNTVSKQLAMDVQQMLLEFGVISRRYLHAAGEYKVVITDRAQAELFPKQIGFGGAKQTELSKILAAMPPCAGRDSDHVPGLARFIRRHCDSRWVDKEWLHKHNIDHLSRWRRDGAEILSHIADPDVRTIATDLTDGRFYYARVASVTDTGVQPVYSLRVDTDDHAFLTNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium malmoense

Length

473 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

52.436 kDa

Fragment

single

Sequence

MGNYHPHGNASIYNTLVRMAQPWSLRYPLVNGQGNFGSPGNNPPAAMRYCCTGDALVRLPFGHSVRIGNFVPAACPNSDNAVNLKVLDRHGDPVVADQLFHSGEHQTYTVRTAEGYEVTGTSNHPLLCLVDVGGVPTLLWKLIEEIRPDDHVVLQRTPPVEFGPADWHDVMEALLLGAFISEGFVSEVRAGFNNCDRDYFAMVVGAYDAVVGGRRYVSSRRIASGSTLHELDIQNIKELKEARLGDLCGQRPADKSVPDWLWHSPAAVKRVFLQALFEGGGSCSALPRNMIQISYSTRSRQLAVDVQQMLLEFGIITRRYRHAVGEHKVLITNRAQAELFATRVGFGGAKQEKLTKILGSMPPCAGMDSDHVPGLARFIRKHCGSRWVDKDWLNRHNVDRIQRWRTSGEKILSHIADPDVRAIATDLTDGRFYYAKVASVTEAGVQPVYSLRVDTDEHAFLTNGFVSHNTEAR

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Mycobacterium xenopi

Length

327 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

35.386 kDa

Fragment

single

Sequence

RPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSMRYPLVDGQGNFGSPGNDPPAAMRYCITGDALVALPEGESVRIADIVPGARPNSDNAIDLKVLDRHGNPVLADRLFHSGEHPVYTVRTVEGLRVTGTANHPLLCLVDVAGVPTLLWKLIDEIKPGDYAVIQRSAFSVDCAGFARGKPEFAPTTYTVGVPGLVRFLEAHHRDPDAQAIADELTDGRFYYAKVASVTDAGVQPVYSLRVDTADHAFITNGFVSHNTEAPLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN

Protein

DNA gyrase subunit A: gyrA

Gene

gyrA

Protein

DNA gyrase subunit A

Organism

Streptomyces niveus

Length

21 amino acids

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Similarity

Belongs to the type II topoisomerase GyrA/ParC subunit family.

Mass

2.202 kDa

Fragment

single

Sequence

MADENTPVMPEEVPAVEGVGM