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gulp1

Gene
GULP1
Protein
PTB domain-containing engulfment adapter protein 1
Organism
Homo sapiens
Length
304 amino acids
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Similarity
Belongs to the ced-6 family.
Mass
34.49 kDa
Sequence
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC

Gene
Gulp1
Protein
PTB domain-containing engulfment adapter protein 1
Organism
Mus musculus
Length
304 amino acids
Function
Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6.
Similarity
Belongs to the ced-6 family.
Mass
34.47 kDa
Sequence
MNRAFSRKKDKTWMHTPEALSKHYIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCFVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGMQKRIQDLETENMELKNKVQDLESRLRTTQVSTSPAHGVTVMSPSTDIFDMIPFSPISHQSPTSARNGTQLPPIPSRSAETKRDLFGAEPFDPFNCGSGDFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC

Gene
Gulp1
Protein
PTB domain-containing engulfment adapter protein 1
Organism
Rattus norvegicus
Length
304 amino acids
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).
Similarity
Belongs to the ced-6 family.
Mass
34.285 kDa
Sequence
MNRAFSRKKDKTWMHMPEALSKHYVPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCFVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGMQKRIQDLETENMELKNKVQDLENRLRTTQVSSTPAGGVTVTSPSTDIFDMIPFSPISHPSPTSAGNGTQLPPIPSRSSEIKRDLFGAEPFDPFNCGAGDFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC

Gene
gulp1
Protein
PTB domain-containing engulfment adapter protein 1
Organism
Danio rerio
Length
300 amino acids
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. May play a role in the internalization and endosomal trafficking of various lrp1 ligands (By similarity).
Similarity
Belongs to the ced-6 family.
Mass
33.86 kDa
Sequence
MNRAFNRKKDKSWMHTPEALAKHFIPYNAKFLGNTEVDQPKGTEVVKDAVRKLKFQRHIKKSEGQKLPKVELQISIYGVKILDPKSKEVQYNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYKKFLESGGKDVETRKQIGGLQKRIQDLETENVELKKQLQVLEEQLMIAQVPPGNSMSSKSPTDIFDMVPFSPMTPLVPLPASNGSAPPPPARPTEIRRDLFGAEPFDPFTCGAADFPPDIQSKLDEMQEGFKMGLTVEGTVFSLDPLEGRC