Protein
PTB domain-containing engulfment adapter protein 1
Organism
Rattus norvegicus
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).
Similarity
Belongs to the ced-6 family.
Sequence
MNRAFSRKKDKTWMHMPEALSKHYVPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCFVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGMQKRIQDLETENMELKNKVQDLENRLRTTQVSSTPAGGVTVTSPSTDIFDMIPFSPISHPSPTSAGNGTQLPPIPSRSSEIKRDLFGAEPFDPFNCGAGDFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC