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grdH

Gene
grdH
Protein
Betaine reductase complex component B subunit beta
Organism
Peptoclostridium acidaminophilum
Length
437 amino acids
Function
In the first step of betaine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
Similarity
Belongs to the GrdB/GrdF/GrdH family.
Mass
47.613 kDa
Sequence
MKKAILYLNQFFGQVGGEDKADYEPEIINGQVGAAMMLNGVLEGAEVTHTIICGDNFMGTYKDEAVSRIMGFLEDKEFDIFLAGPAFQAGRYGVACGEICKVVKEKYNVPVVTSMHVENPGVQMFKKDMYVMIGGNNAGRMRQDMSAMAKVANKIIAGEKIGPADEEGFFPRGKRHQHWREDGKPASERVVDMLLKKLSGEEFQTELPIPKSDRVEIAAPIKDLSKATIAVVTTGGIVPVDNPDRIQSASATRWGMYDVTGLERLEGGVYKTIHAGFDPAAADADPNVIVPLDALRAYEKEGKIGKVHEYFYSTVGTGTTEAEAARMAKEIVVKLKQGGVDGVIMTSTUGTCTRCGATMVKEIERAGFPIVQMCNLIPVASTVGANKIVPTISIPYPLGDPSTSKEQQWKLRYHRVGTALDALTVDVQEQTIFKVKI