About Products Protein Database Contact

grdE

Gene
grdE
Protein
Glycine reductase complex component B subunits alpha and beta
Organism
Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654)
Length
430 amino acids
Function
In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity).
Mass
46.476 kDa
Sequence
MRLEVGNIFIKDIQFGDSTKVENGVLYVNKQELISELSSDEHIKSIDMEIVRPGESVRIAPVKDVIEPRVKVEGNGGIFPGFLSKVDTVGEGKTNVLKGAAVVTTGKVVGFQEGIIDMTGPGADYTPFSKTCNVVIIAEPVDGLKQHDHEAALRMVGLKAGKYLGEAGRNITPDEVKVYETKPIFESVKEYPNLPKVAYVYMLQTQGLLHDTYVYGVDAKKIIPTLIYPTEVMDGAILSGNCVSACDKNPTYVHMNNPVIHDLYELHGKEYNFVGVIITNENVYLADKERSSNWTAKMAEYLGLDGVIISEEGFGNPDTDLIMNCKKITKKGIKTVILTDEYAGRDGASQSLADADAAADACVTGGNANMTIVLPKLDKIIGHVSKDVIDVIAGGFDGSLRADGSIEVEIQAITGATSEVGFNKMTAKTY

Gene
grdE
Protein
Glycine reductase complex component B subunits alpha and beta
Organism
Peptoclostridium acidaminophilum
Length
428 amino acids
Function
In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
Mass
46.263 kDa
Sequence
MRLEIGNIFIKDIQFGEQTKVENGVLYVNKDEMIKKLSVIEHIKSVDLDIARPGESVRITPVKDVIEPRVKVEGPGGIFPGVISKVETDGSGRTHVLKGAAVVTTGKVVGFQEGIVDMSGVGAEYTPFSKTLNLVVIAEPEDGIEQHRHEEVLRMVGLNAGVYIGEAGRSVTPDEVKVYETDTIFEGAAKYPNLPKVGYVYMLQTQGLLHDTYVYGVDAKKIVPTILYPTEVMDGAILSGNCVSSCDKNPTYVHCNNPMVEELYAMHGKEINFVGVIITNENVYLADKERSSDWTAKLCKFLGLDGAIVSQEGFGNPDTDLIMNCKKIEMEGVKTVISTDEYAGRDGASQSLADADVRANAVVSNGNANMVIVLPPMDKTIGHIQYIDTIAGGFDGSLRADGSIEVEIQAITGATNELGFGYLSAKGY