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glrx5

Gene
GLRX5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Homo sapiens
Length
157 amino acids
Function
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).
Similarity
Belongs to the glutaredoxin family. Monothiol subfamily.
Mass
16.628 kDa
Sequence
MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK

Gene
GLRX5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Homo sapiens
Length
157 amino acids
Function
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).
Similarity
Belongs to the glutaredoxin family. Monothiol subfamily.
Mass
16.628 kDa
Sequence
MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK

Gene
glrx5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Danio rerio
Length
155 amino acids
Function
Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis.
Mass
17.377 kDa
Sequence
MNSVFRSTARCLRSATWQYKTAHKNGELSVGRARLMCSSAGQKNLEEMVKKDKVVVFMKGTPAQPMCGFSNAVVQILRMHGVDNYASYNVLDDQDVRQGIKTFSNWPTIPQVFFNGEFVGGCDILLQMHQSGDLVEELQKLGIRSALLDQEKESK

Gene
glrx5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Danio rerio
Length
155 amino acids
Function
Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis.
Mass
17.377 kDa
Sequence
MNSVFRSTARCLRSATWQYKTAHKNGELSVGRARLMCSSAGQKNLEEMVKKDKVVVFMKGTPAQPMCGFSNAVVQILRMHGVDNYASYNVLDDQDVRQGIKTFSNWPTIPQVFFNGEFVGGCDILLQMHQSGDLVEELQKLGIRSALLDQEKESK

Gene
Glrx5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Mus musculus
Length
152 amino acids
Function
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (PubMed:19442627).
Similarity
Belongs to the glutaredoxin family. Monothiol subfamily.
Mass
16.292 kDa
Sequence
MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK

Gene
Glrx5
Protein
Glutaredoxin-related protein 5, mitochondrial
Organism
Mus musculus
Length
152 amino acids
Function
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (PubMed:19442627).
Similarity
Belongs to the glutaredoxin family. Monothiol subfamily.
Mass
16.292 kDa
Sequence
MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK