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glkA

Gene
glkA
Protein
Glucokinase
Organism
Aspergillus niger
Length
495 amino acids
Function
The enzyme has great affinity for glucose. Mannose, 2-deoxyglucose and glucosamine can serve as substrates.
Similarity
Belongs to the hexokinase family.
Mass
54.537 kDa
Sequence
MSSALLDEAARIARQFDYPAAEVQRGVTEYIREIDEGLSKEHTTLSQIPTYVTAVPNGTEKGLYLAVDLGGTNFRVCSIDLHGDTTFSLTQSKIMIPRETMASGTAKDLFLFLARQIESFLRIHHNDHFEAHLRRRNEKNGNCEEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGKDVCALLQNAIDDLGLPVRVAALVNDTVGTLMARSYTSPGETGTFLGAIFGTGTNGAYVEKLDRITKLQTIEHSEYDKTTGEMIINAEWGSFDNHLSVLPNTIYDQQLDADSNNPGIQMFEKRVSGMFLGEILRRVMLDMQRNESLGFLRAGGASTVSVPQESSLYRQWGIDTSLLSLVEADKTENMEQIKVALKDHLKIERPTTDDCKAIQTVVHAIGKRAARLSAVPLAAILLSTGKLQKDDLVDIGVDGSLVEFYPNFEGYMRDALREVPEVGEAGNKKIRIGISKDGSGVGAALIALVASKEETRRKSQ
Protein
Glucokinase: glkA

Gene
glkA
Protein
Probable serine/threonine-protein kinase glkA
Organism
Dictyostelium discoideum
Length
473 amino acids
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Mass
52.554 kDa
Sequence
MTIPTDNNSSNNKGYNDNNNNNNNNNNNNNNNNNNNNNNNKEHPNINNNNNNNNNNNNNNIKESSSSNSNHSSSQSSSTATVNSNPKVYPYEIIKQVGQGTFGKVYEAKNQDNKRVAIKKVEKSNHFISREYDILKIVAHPNCLRILDMFYTAEDNKKMQNLVFDFIPYTLASLLKKRQLSINFIKVLFYQLCQAIKHIHSKAICHRDITPNNILLSSKGELTLADFGSAKILESNHTSMSYICSRYYRAPELLVGCSNYTTKIDIWSIGCILAEMLIGKPLFPGTNSNDQLGRIIEVLGSPTKDDMEAMKPSKPYHLQLPNINPKFFESLHNVEDKTVVDLLSKIFIFDPVKRASIDEIIAHPFLRDVNINSLELFDEMKCFSVSGNGKSSLTTNSTSSSSTTANMTSLASSSSNNKTTCSETYLSRLPTSAITSSSNLKSIDNSNNGKSSSSSNNIPSLNNSNNGVITNTI
Protein
Probable serine/threonine-protein kinase glkA: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Length
467 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. Can also use CDP as the phosphoryl group donor and D-glucosamine and D-1,5-anhydroglucitol as the phosphoryl group acceptor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
53.621 kDa
Sequence
MKESLKDRIRLWKRLYVNAFENALNAIPNVKGVLLAYNTNIDAIKYLDKDDLEKRVTEIGKEKVFEIIENPPEKISSIEELLGGILRSIKLGKAMEWFVESEEVRRYLREWGWDELRIGGQAGIMANLLGGVYRIPTIVHVPQNPKLQAELFVDGPIYVPVFEGNKLKLVHPKDAIAEEEELIHYIYEFPRGFQVFDVQAPRENRFIANADDYNARVYMRREFREGFEEITRNVELAIISGLQVLKEYYPDGTTYRDVLDRVESHLNILNRYNVKSHFEFAYTANRRVREALVELLPKFTSVGLNEVELASIMEIIGDEELAKEVLEGHIFSVIDAMNVLMDETGIERIHFHTYGYYLALTQYRGEEVRDALLFASLAAAAKAMKGNLERIEQIRDALSVPTNERAIVLEEELEKEFTEFENGLIDMVDRQLAFVPTKIVASPKSTVGIGDTISSSAFVSEFGMRKR
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Length
467 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
53.457 kDa
Sequence
MKESLKERIKLWKNLYMNAFENAVNAIPNVEGVLLAYNTNIDVIKYLNKDDLERRINQIGKERVFEVIKAPTERISSLEHLFGGILRSIKLGKAIEWFVENEEIRRYLREWGWDELRIGGQAGIMANLIGGVYRIPTIVHVPQNPKLQADLFVDGPIYVPIFEGKELKLVHPKEAVKEENELIHYIYEFPRGFQVFDIQAPRENRFIANADDYNARVYMRKEFKESFEKIAKGVELAIISGLQVLKEYYSDGTTYRDVLDRVESHLNILNRYGVRSHFEFAYTPNRLVREELIGILSKFTSVGLNEVELASIVEIIGDETLAKEVLEGHVFPIIDAINLLMDETGIDRIHLHTYGYYLALTKYRSEEVRDALLFASLAAAAKAMKGNIEKIDHVKDALSVPTNERAIVFEEELEKEFTEFENGLIDMVDRQLAFVPTKIVTSPKSTVGIGDTISSSAFVSEFAMRKS
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
457 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
52.09 kDa
Sequence
MITMTNWESLYEKALDKVEASIRKVRGVLLAYNTNIDAIKYLKREDLEKRIEKVGKEEVLRYSEELPKEIETIPQLLGSILWSIKRGKAAELLVVSREVREYMRKWGWDELRMGGQVGIMANLLGGVYGIPVIAHVPQLSELQASLFLDGPIYVPTFERGELRLIHPREFRKGEEDCIHYIYEFPRNFKVLDFEAPRENRFIGAADDYNPILYVREEWIERFEEIAKRSELAIISGLHPLTQENHGKPIKLVREHLKILNDLGIRAHLEFAFTPDEVVRLEIVKLLKHFYSVGLNEVELASVVSVMGEKELAERIISKDPADPIAVIEGLLKLIKETGVKRIHFHTYGYYLALTREKGEHVRDALLFSALAAATKAMKGNIEKLSDIREGLAVPIGEQGLEVEKILEKEFSLRDGIGSIEDYQLTFIPTKVVKKPKSTVGIGDTISSSAFVSEFSLH
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
455 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. Can also use CDP as the phosphoryl group donor and D-glucosamine and D-1,5-anhydroglucitol as the phosphoryl group acceptor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
51.266 kDa
Sequence
MPTWEELYKNAIEKAIKSVPKVKGVLLGYNTNIDAIKYLDSKDLEERIIKAGKEEVIKYSEELPDKINTVSQLLGSILWSIRRGKAAELFVESCPVRFYMKRWGWNELRMGGQAGIMANLLGGVYGVPVIVHVPQLSRLQANLFLDGPIYVPTLENGEVKLIHPKEFSGDEENCIHYIYEFPRGFRVFEFEAPRENRFIGSADDYNTTLFIREEFRESFSEVIKNVQLAILSGLQALTKENYKEPFEIVKSNLEVLNEREIPVHLEFAFTPDEKVREEILNVLGMFYSVGLNEVELASIMEILGEKKLAKELLAHDPVDPIAVTEAMLKLAKKTGVKRIHFHTYGYYLALTEYKGEHVRDALLFAALAAAAKAMKGNITSLEEIREATSVPVNEKATQVEEKLRAEYGIKEGIGEVEGYQIAFIPTKIVAKPKSTVGIGDTISSSAFIGEFSFTL
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
453 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
50.735 kDa
Sequence
MNWDGLYASAFERIRDNIGKVGNVLLAYNTNIDAIKYLEREDLERRIGAAGREEVLPYSEKLPKRIESVPQLLGSILWSIRRGKAAELFVESCSTRFYMRRWGWDELRMGGQVGIMANLLGGVYGVPVIAHVPQLSRLQAELFKDGPIYVPKVEGGKLKLVHPKEFKADEENCIHYIYEFPRGFRVFDFEAPRENRFIGSADDYNTNVVIRPEFEEHFGEIAEKTELAIISGLQALTEGNYREPFETIKEHLDVLEGKGIPAHLEFAFTPDETVRKEILGVLGKFWSVGLNEVELASIMDVMGEKTLAEKLLAHDPVDPIVVTKAMLKLAEKTGVRRIHFHTYGYYLALTDYRGEFVRDALLFAALAAAAKAKLGDVRNIDDVVKAMDVPVNEKAKGVEEALTKEYGMENGIAEVNGYQLAFIPTKIVAKPKSTVGIGDTISSSAFVGEFALR
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
ADP-dependent glucokinase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
452 amino acids
Function
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
Similarity
Belongs to the ADP-dependent glucokinase family.
Mass
51.572 kDa
Sequence
MSWDEMYRDAYERVLNSIGKIKGVMLAYNTNIDAIKYLKREDLERRIEEAGKDEVLRYSDELPKKINTIQQLLGSILWSVKRGKAAELLVEDREVRNYMRQWGWDELRMGGQVGIMANLLGGVYGIPVIAHVPQISKLQASLFLDGPIYVPTFEEGLKLVHPRNFEGNEEDCIHYIYEFPRGFKVLNFTAPRENRFIGAADDYNPRLYIRKEWVERFEEIAERAELAIVSGLHSLTEETYREPIKVVREHLKVLKDLNIKTHLEFAFTADEKVRREILGLLSLVYSVGLNEVELASVLEIMNERELADRILAKDPADPVAVIEGLMKLIEEGVERIHFHTYGYYLAITKYRGEHVRDALLFSALAAATKAMLGNIEKLDDLRKGLEVPIGRQGLEVYEVVKREFNVEKGIGEVGDYQIAFVPTKIVEKPKSTVGIGDTISSSAFVSEFSLSS
Protein
ADP-dependent glucokinase: glkA

Gene
glkA
Protein
Glucokinase
Organism
Staphylococcus xylosus
Length
328 amino acids
Similarity
Belongs to the ROK (NagC/XylR) family.
Mass
35.033 kDa
Sequence
MNKIILAADIGGTTCKLGIFDENLNRLSKWSIDTDTSDTTGYLLLKNIYDSFIQHIDKSDNTFSDVLGIGIGVPGPVNFETGEVNGAVNLYWKGTVNVRDIFKQFVDCPVYVDNDANVAALGEKHKGAGNGADDVVAITLGTGLGGGIISNGEIVHGHNGSGAEIGHFRVDHDQRFKCNCGKSGCIETVASATGVVNLVNFYYPKLTFKSSILQLIKDNKVSAKAVFDAAKAGDQFCIFITERVANYIAYLCSIVSVTSNPKYIVLGGGMSTAGLILIENIKTEYHNLTFTPAQQNTEIVQAQLGNDAGITGAAGLIYTYIIEKDGVK
Protein
Glucokinase: glkA

Gene
glkA
Protein
Glucokinase
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
317 amino acids
Function
Required for glucose repression of many different genes.
Similarity
Belongs to the ROK (NagC/XylR) family.
Mass
33.062 kDa
Sequence
MGLTIGVDIGGTKIAAGVVDEEGNILSTHKVPTPTTPEAIVDAIASAVEGARVGHEIVAVGIGAAGYVNRQRSTVYFAPNIDWRQEPLKEKVEARVGLPVVVENDANAAAWGEYKFGGGKGHRNVICITLGTGLGGGIIIGNKLRRGHFGVAAEFGHIRMVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPERAEVLLALGDGTPDGIEGKHISVAARQGCPVAVDSYRELARWAGAGLADLASLFDPSAFIVGGGLSDEGDLVLDPIRKSYKRWLVGGNWRPVADVIAAQLGNKAGLVGAADLAREPDPIM
Protein
Glucokinase: glkA

Gene
glkA
Protein
Glucokinase
Organism
Streptomyces lividans
Length
317 amino acids
Function
Required for glucose repression of many different genes.
Similarity
Belongs to the ROK (NagC/XylR) family.
Mass
33.062 kDa
Sequence
MGLTIGVDIGGTKIAAGVVDEEGNILSTHKVPTPTTPEAIVDAIASAVEGARVGHEIVAVGIGAAGYVNRQRSTVYFAPNIDWRQEPLKEKVEARVGLPVVVENDANAAAWGEYKFGGGKGHRNVICITLGTGLGGGIIIGNKLRRGHFGVAAEFGHIRMVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPERAEVLLALGDGTPDGIEGKHISVAARQGCPVAVDSYRELARWAGAGLADLASLFDPSAFIVGGGLSDEGDLVLDPIRKSYKRWLVGGNWRPVADVIAAQLGNKAGLVGAADLAREPDPIM
Protein
Glucokinase: glkA