Protein
MFS gliotoxin efflux transporter gliA
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Efflux pump that provides the dual role of gliotoxin export and self-protection by allowing the fungus to evade the harmful effect of its own gliotoxin production (PubMed:15979823, PubMed:15707846, PubMed:24847038, PubMed:26150413). Moreover, it contributes also to the virulence through gliotoxin secretion (PubMed:24847038).
Similarity
Belongs to the major facilitator superfamily.
Sequence
MSRPSIEESKQELSSSPNDSVMGKDPAPEEEMQYPSGFALSVIMAGLLAAIFLISLDTTIVSTAIPRITDEFHTVADIGWYGSAFFLTLASFQGTWGKIYRYFPLKLSFLAAVLLFEVGSLICAVAKNSVTLIVGRAIAGIGAAGISSGSYTILAFSVHPRRRAAMTGAIGASFAVAAVAGPLIGGAFTSHTTWRWCFWINLPIGGVSAGLIAIFFKAPPQARAKDVPYKEILLQMDPSGIVLLLGAILCFLLALQWGGSAKAWGNADVVGTLVGFGLLLIAFAINELWLQEKAMIPPRLFKGQTILFSSLFTFFFSGSFYLLLYYLPTYFQSVKGASASDSGVRTLPLVLGDGLFATLSGAVLGIIGYYMPLLTLGGVLTTVASGLLYTLDLDSGANAWIGYQAMAGIGIGLAIQVPMMASQAVVRVEDLSTVSAIVLFFQCMGGAIFVQAGQAAFTNKLVQEVQRHLPNISAARVTSTGATELQSEFHGHELQVILEAYVAGLKDAFIVAIVLAGIATLLSFGSGWRSVKSKKEEPKAQP