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gefA

Gene
gefA
Protein
Ras guanine nucleotide exchange factor A
Organism
Dictyostelium discoideum
Length
605 amino acids
Function
Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase (PubMed:17380187). Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:8793298, PubMed:16234315, PubMed:20493808). The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).
Mass
70.793 kDa
Sequence
MITPTSFEPVELLYSKKKVNRTNWKKNVLKSNPEINNLCERIYPINRAIQFGKQFHPGKAEVKQKLDKTAIIQLILQHLSTKGLKQTKQTLEKEARTTTPIVEGLNESRLVTYIRNALKDTDRIYDLSMEHTEYSKEERQSKITEREELLFQMDLLEDEDEDDGVNIWDEPTENIITEKVHTTEYDINKSKENKDDQDDEVVKFASLNKLVEHLTHDSKHDLQFLKTFLMTYQSFCTPEKLMSKLQQRYNCPSGHDEMATRNIQIRVINVLKGWVDNYYSDFDDKLIAMLRTFIDQIQIKFPAPASAVNKSLTKMVEKLSPVNDSKHIFNEKTPEPMVPKNIFSNNLSIYDIDEEEIARQLTLIEFEIYRNIKPPELLNQSWNKTKLKSRAPNVLKMIDRFNSVSMWVATMIIQTTKVKARARMMTRFIKIADHLKNLNNYNSLMAIIAGLNFSSVYRLKYTREELSAQTMRTYSDLEKIMNSEGSFKTYRTRLQNVPPMLPYLGVHLTDLTFIDENPNNFVTDVGGKQVSLINFTKRTLVFKIISLIQETQVVPYNLQPVHQIQEFLLNIRSDLKAHTLDQYQQELYRESLKREPKKAQRSDVL