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garem1

Gene
GAREM1
Protein
GRB2-associated and regulator of MAPK protein 1
Organism
Homo sapiens
Length
876 amino acids
Function
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
Similarity
Belongs to the GAREM family.
Mass
97.186 kDa
Sequence
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI

Gene
Garem1
Protein
GRB2-associated and regulator of MAPK protein
Organism
Mus musculus
Length
876 amino acids
Function
Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity).
Similarity
Belongs to the GAREM family.
Mass
97.25 kDa
Sequence
MDPAPSLGCSLKDVKWSPVAMPLDLLVSTYRLPQIARLDSGECVEGLRENDFLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEEITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHQVKGDMWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEDCKSPKKGRCSGHNHLPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGEWAPFPHDILPYQDSGDSGSDYLFPEANEESAGIPGKTEVPYEELWLEEGKPSRQPLTRSLSEKSRCDTLRGSTRSTCAPSSPPTPATLGATIKSSEIALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPVRPQTRSPSPTLSYYSSGLHNIITQSDTSPPNSAPVSCYPCTRVKSDSVDPKSPFGSPSAEALSSRLSWPNHYSGASENQTRSDFLLDPSRSYSYPRQKTPGTPKRTCPAPFDFEGCELLGSPPSTTSAEFSSSGVPSCPKSASYCLENSEDNSFAAGMTKQSVSCPALPPRAPKPVEQKATPETSPLPLKIDGAEEDPTAGSLDLSEDQYFVRKGMQDIFSVSYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVIAFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKILQFINGWRPKI

Gene
garem1
Protein
GRB2-associated and regulator of MAPK protein
Organism
Xenopus laevis
Length
876 amino acids
Function
Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity).
Similarity
Belongs to the GAREM family.
Mass
97.431 kDa
Sequence
MELPVPSLKDVKWSSASFPLDLLVSSYRLPQLVRVDCAGENVEGLRENDCLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYGGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEEITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTSKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLEIQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNSYDLHFIREGHRYKFVNIQTKTVVVCFALHTNKIVPMHFPLHLSVPKFSLPENLIKGEVWQDSVVQHWYNICQEQFDIEEYSRAVRDVKADWSEECKSPKKNWSAGHSHIPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLCGDWAAFPQDSPQYQDSCDSGSDYLFSETSEELTSLPAKPELPYEELWLEQGSVKRSGQPLTRSQSEKNKCDSFRGSLPSRCGTSSLPSPGALLTTKSLDVSLPPPPVPPKSEAVKEECRLLNAPPVPPRSSKPSSPTPSVPPAAENIVRQQTRSPSPTLSYYSSGLHSIGITESETTSSSDNSQVSCYPCNWMKNESSDLESNLTCGSASSEALPSRLSWPNRYCGGAEGLNVNDLPMDQCRSYYSYPRQKTPGTPKKNSPATFDFGGCGSFTGCNQGEFSDTVPGCPKSASYSLESATDRMLGDNSTKQSLSCPALPPRAPKPSEGNALSEPLSLPMKIDGAEEEIQTCSPDFLEEHYLAKKGVQDIFSISYPFSSPLHMQLAPRSCGDGSPWQPPTDLSGLSVEEVSKSLRFIGLSEDVVSFFVSEKIDGNLLVQLTEEILSEDFKLSKLQVKKLLQFINGWRPKM

Gene
garem1
Protein
GRB2-associated and regulator of MAPK protein 1
Organism
Danio rerio
Length
867 amino acids
Function
Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity).
Similarity
Belongs to the GAREM family.
Mass
95.793 kDa
Sequence
MDLGSMLYNSFNNITWSTTTLPLDRLISSYRLPQIVKLDSGESVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYEGQFKLLEQDRDIKEPVQYYNSVEEVAKAFPERVYVMEEISFNFKMASGESNEDTEVYNITLSTGDELTLMGQAELLYAKSSREKSRFNTIFKRIGKLNSISKLGRGKMPCLICMNHRTNESISLPFQCRGRFSTCSQLELQMQEGEHTIRTIVEKTRLPVNVMVPSSPPRNPHDLHLIREGHRYKLVNIQTKTVVVCCALRSNKILPVHFPLHVSTALPRLLVPEGLLQGESWFETVVHRWFTYCQEQFDIDDYSRAVRDVRVDWIEDGKSPKKSSAGGTGSGSAICNSSGSGSNGCPSHLHLPSSLSSARDELTQSFHRLSVCVYGNNLHGNSEVNLQGCVSLCGDCAPAEPPDADYLFPELQENSSGSLKSDVPYEELWLDHVKNAGPVLDHNEGVRGNSLSSGCTTALPYPKAGPTSALLSADVNLPPPPVPPKSEAVKEECRLLDAPPIPPRSSKQAGSSSATVPYPSAKPRQKDTRSPSPTLSYYSSGLHSIGGEGESQIESDDQNHACYPCSWIRPDASESSKPLPCLNPSVNASFSRLSWPNDFCGADSYKGEDFQSLHCRSYSSYPRKRTPGTPKACPSGLLDFDKRANFEGKAVSSKVQQVTQSAQFCTKSTSYNMDMCRDKPTDECITKQSQSCPILPPRTPKCTDAKKDAEAATTDTADADAVELESKSCSPDGPHPGTTDVFSVSHPVATGLSWQPPSNLSGISIEEISKSLRFIGLSEDVVSLFVQEKIDGNLLLQLTEEILSEDFKLSKLQVKKLMQFINGWRPKM