Function
GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues.
Sequence
MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEGNPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFARHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMSIEFFDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNLSTRLSGSTQNLNQPTNAYGNLLSRPFRSNPLKRTKSVSKMEKSLAEANQHSLHRVDASNTPSRDSSLYAQPPARRHLSQPAREGSLRACRSHESLLSSAHSTHMIELNEDNRLHPVHPSIFEVPNCFRLASTYYSCRTPLERAKWMENLRKTMNPRRDQQRRTENSMLIWILEAKGLPAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLSSRSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLETLCYNYLPLCEQLEPVLNVRDKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESKSGPEKNADAIVDAGKELSLIATYLEEAWTPLLQEKNGNKHPLSNVKSVLSELAECKRRSDNGVFHSPMVQQPSSDYENSPQQHVVPRHENVPAYRSTPPTGQATVLGRSTNRPATHLLTSDDYVLSSAFQTPSLRPGGTRLSDETGTSSSRTSDKTTSSAEIRDDTDSDFELREDRGRGGRNRKRLPRTDASPSSSQQASSGYLSNNPSRSSYSNSSSSSPVERMAALSIANPVFGPGPSSGYAIPAEPKEIVYQKRASPPPYDPDVHNYHYQPMQVYAVPPDCQVSPRTQATGGVNAQNRLSLPRTNPRASRNSTLLRPSVVNVPDDWDRTSDYWRDRGENNYRSQLESQVESQAREIERLMRENIELKSKMMSSTKTVDSKRSDSGASEDSYDSLSSLDRPSRQSLVVVPN