Protein
12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Catalyzes the prenylation of 12-alpha,13-alpha-dihydroxyfumitremorgin C to fumitremorgin B in the biosynthesis of indole alkaloids such as fumitremorgins and verruculogen. Also shows activity with fumitremorgin C (By similarity).
Similarity
Belongs to the tryptophan dimethylallyltransferase family.
Sequence
MTIATEISCPEEEAFQLLDKYSWFPNDDQRRWWEYTGPNLLKLLRDAQYPQKDQISCLYLLQQLLVPYLGTFPVAGQAPLPWWSNVTTYGVPFELSWNLLHNIVRIGFEPLSHLAESGVDAFNKIAPEECLSRLACLDNTIDLARFRHFQHQLLVTPDEERRLLEEKGPLPKSGRGQQALAVEFQNGGISAKAYFFPGMKSLATGLSPGKLILDSIESLALPGLKEPVHHLCNSLGLQDDGHPTDTAIAPFLLGVDLCTPERSRLKFYVTDQVVSWDRVADMWTLRGKRLEDPQCADGLTLLRKLWDLLEIPEGYRSNIRPDFAFGTPPPEDYRPVMMANWTLSPKKKFPDPQIYLLTVGMNDAVVMDALVAFYEVLGWTDLASTYKDKVASY