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fsdH

Gene
fsdH
Protein
Cytochrome P450 monooxygenase fsdH
Organism
Fusarium heterosporum
Length
564 amino acids
Function
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fusaridione A, a bright yellow trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:23614392). The PKS module of fsdS catalyzes the formation of the polyketide unit which is then conjugated to L-tyrosine by the condensation domain of the fsdS NRPS module. Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate fusaridione A (PubMed:23614392). The unstable pyrrolidinedione ring of fusaridione A is opened through a reverse-Dieckmann reaction to afford its ring-opened form (PubMed:23614392).
Similarity
Belongs to the cytochrome P450 family.
Mass
63.743 kDa
Sequence
MALTVFEHASALWYRLQGSVSLAVLSTLAVVIAGWYILSSISLYFSRRQFIALHGCKPIANRYPSKWFGINFILEAGRTYKERRYLDALTWNFRNIGYTHEVRALGGTSVWTVEPENIKAVLTSKFKDYSLGNRPAVMGPLLGRGVFVTDGEEWSHSRALLRPNFAKDQVADLSMIERHLQQLLKMIPDDGKAIDLNDLILSFTMDSSTEFLFGESTETLTSGINRQFSDAFAYSLHDISSGLRLGPWYKFRRTDPKAVQSHRICREYADKYVEKALEYRRNYIKSVEDGATDKPSIDGGDSRRTFLRELALATDDREKLRDELLSLLLAGRDTTASLIGSLLFSLAKKPECWEKVRSEIEETLHGDLPSYEQLRNFKYAKYCVNEALRLYPPVPNNAKIAIRDTVLPRGGGPEGRDPIIVPKDAPVIYTVYALHRRYDLFGDDADDFRPERWENQRYTWEFLPFNGGPRICLGQQYALVETLYVLVRFAQHFSKIESMDPEPWTESLALTVSSGNGVKVKLERGSSDVHGLSTQGVLIDYGGLFAPTQKVPGTGVTQISKGKA