Function
Key regulator of adhesion dynamics, it acts as an anti-adhesive. Plays a critical role in the regulation of cell-cell adhesion, multi-cellular development and, in particular, the formation of the organising center known as the tip. Required for turnover of paxillin-adhesion sites during cell migration. Plays a major role in normal cell shape, cell-substrate adhesion and actin cytoskeleton organization.
Sequence
MAVLSLVELCFISIMERMEYNNQALQKIPPQLIERLINFMVYKLPPNHLSLQTISKPIRIKLVRQNRVITMRFSIYNTIDKIIHQIYERIINEEKMEQNEKQKNSSNNNLLSLLTLNNNNQNNNSSIITTTTTTTNNNNNSNCGSSSSSSSSKQILWGSIENYGLFQQSGSFRNARWLQLDKTLAYYEIDSNETLEFKTCKSVLKIRFFGPWERVVHPLHQSTMLDETIKTFVFDESKTVSEISMELAKKLQLKYPEELSLKVQCEEEDDGRGIWLSADLTLPEQGIDPLYTIFLLKRQFFFCKDIIIDFSMDAEMLHFVFCQCLDAIIDTSHPCSPTESILFAALQCQICFGDYVHGSKEIDQIRQRDFLPMEFINQKNILKEILIQYQRLIGMSEQKAKLNYIQLAKSLKTYGYTFFKVTNRQTSIVNNNLSSSGGSGNGSGSGNGSSSSSSNSSSGNNNNHNHHNHQQLFGISSEAVLTLDPMTNNTISLYSLSNIRKWHVLNNVFTIEYNDRKDTFISMEAEAISHVLSSYIHHNLRETPSIQKQWDQNYLSVSGRNSLTNGRKRLSTCSNCSSDSMEFDSSKSNTKDKDWKYQYGLVIKKCALYIEPKKLYINPLSTQITGSMVNKELNKDTKVTKVLKVLTDLSSKMILSFSKSSPAKEREIVVKFSDKKVKSFVVDEQKTVSEITQEIGLKLGIKNPEEFSLQLIVNNKNNNNNNNSNNSSTSSSSSSSVNNSGIFDGLNNSNVNNVFYNSYIVNSSISNNSNSNSNSNILNNSNDEQSTSTSTSSSLGGIWLKPYQPLSEQSISPDSKLLFKKKFYTSDIGAADDCNSDPVYFNLLFFQSKDAIISNTYTCSKEEAIQLAATLFQINFGDHNPNIHKPGFLKSQDLKFFLPPNSLELWGLSFQKIEKSIYKEHQNLRGIKEVYAKYRYVQLCRSLKTFGAIFFSVRQLLPNKTNGSSSSSSNNNGGNSNNGINGNGIITGGNGGSGGGGSGIGGNGSGINTGGNGFGGSQQIPINQPLVLGFSRKCILFMTAKTKKFLVEYPLTHLRRWAYHKDTQCLTLDFGDYEMGRIVLQTTESEEISSYLSDYIDYIQTKLVGSQSFSRSIFNSDNNSSSFFSNSFCNNTTTTTTTTTTTTTTTTTTTTNNV