Protein
Flavo-diiron protein FprA1
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Function
Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium.
Similarity
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
Sequence
MSAEKLCENVYWVGVKDQKLRVFDIIMNTKKGSTYNSYLINDDKVAIIDTVKDGFYDEFLKSIKSVIGDKKVDYIVVQHTELDHSGSMYRLIKEYPEAKVVSSKAANMYLKEIVNDEFNSLDAMEVKELNLGKNTLEFISAPNLHWPDTMFTYNKENNILFTCDVMGCHYCPDGSIKDEGGEDYLPEMRYYFDVIMSPFKKFVNMGLDKIKDLKLDMIAPSHGPVHINDIEESVKLYREWAKEKEPKEKNVQIFYITAYGNTGIMAKHLCEDINKKGVKAEVHEITDMKMEDIVELIADANGVLVGSPTINQDAVRPVWDVLSSVCPIVNRGKAAAAFGSYGWSGEGVPMMMDRLKSLKFKTPDNGLKFKFVPASKEFSEADKFVDDFIGLL