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fpoH

Gene
fpoH
Protein
F(420)H(2) dehydrogenase subunit H
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
350 amino acids
Function
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.
Similarity
Belongs to the complex I subunit 1 family.
Mass
38.443 kDa
Sequence
MTFMAIEIPEFIVPFVPWIRGTVGLVLVGAIFLGGMAAVWIERKLSADIQLRYGPSRVGKFGLLQLVADAIKLFTKEDVRPGNADRFLYDNAPVFMLTSLFLMLVAIPVGAVFIDGNLYPLAVTEMDISILFIEAVSAINIFGIFMAAYGSNNKYSLLGAFRNFARMIGYEVPLGIAIVSVAVMTGSLNIIDITSAQGSFVWNIFLQPIGFVVFFIALMADLGRLPFDQNESEEELVAGWVTEYTGMRFGLVFFAEYMHMILGSFLVALLFLGGWNVPAFVANNAVLGLIAPTGILLLKTVLVLMTIIGMRWAVPRFRIDQVVDMSWKKLLPLSLLNLAWAVGLGLYLGA

Gene
fpoH
Protein
F(420)H(2) dehydrogenase subunit H
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
348 amino acids
Function
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Similarity
Belongs to the complex I subunit 1 family.
Mass
38.522 kDa
Sequence
MNIMIEIPEFIIPLIPWIRGVVGLVLVGAIFLGAMGAVWLERKLSADIQFRYGPSRVGKFGLLQLVADAIKLFTKEDMRPRNADRLLFDNAPIFMMSSVFLMLVAIPVGAVFINGVEYPLAVTEMDISVLYIEAMSAITIFGIFMIAYGSNNKYSLLGAFRNFARMVGYEVPLGITVVSVAIMTGSLNIVEIASAQGLLWNIFLQPIGFIVFFIALMADMGRLPFDQNESEEELVAGWITEYTGMRFGLGFFAEYIHMILGSFLVALLFLGGWNVPAFVANNPVLGLIAPTGFFLLKTVLVLMTIIGMRWAVPRFRIDQVVDLSWKRLLPLSLLNLVWAVGLGLYLGA

Gene
fpoH
Protein
F(420)H(2) dehydrogenase subunit H
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
346 amino acids
Function
Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Similarity
Belongs to the complex I subunit 1 family.
Mass
38.027 kDa
Sequence
MTVVIPEYITPLIPWVRGIVGLVLIGVIFMGAMGAVWLERKLSADIQTRMGPCRVGKYGLLQLVADAIKLFTKEDLKPLNADSLLFNNANIFMLGSVFLMLVALPVGAVFINGVEYPLAVTQMDISVLYIEAVSALSIFGIFMVAYGSNNKYSLLGAFRNFARMVGYEVPLGITVISVAAMTGSLNIVDISTAQGLHWNIFLQPLGCFVFFVSLMADMGRLPFDQNESEEELIAGWITEYCGMRFGLGFFAEYIHMILGSFLVALLFLGGWNVPGFIANNSFFGIIVPTGFLIVKVVFVLMVIIGLRWAVPRFRIDQVVDLSWKKLLPLALLNLVWAVGLGLYLGA