foxh1

Forkhead box protein H1

518 amino acids

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription.

57.445 kDa

MRDPSSLYSGFPAGSQYESVEPPSLALLSSIDQEQLPVATGQSYNHSVQHWPQPWPPLSLYREGGTWSPDRGSMYGLSPGTHEGSCTHTHEGPKDSMAGDQTRSRKSKKKNYHRYNKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFNGDYMGWKDSIRHNLSSSDCFKKILKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYKYEHNAGAYGHQMPPSHARSLSLAEDSQQTNTGGKLNTSFMIDSLLHDLQEVDLPDASRNLENQRISPAVAMNNMWSSAPLLYTHSKPTRNARSPGLSTIHSTYSSSSSSISTISPVGFQKEQEKSGRQTQRVGHPIKRSREDDDCSTTSSDPDTGNYSPIEPPKKMPLLSLDLPTSYTKSVAPNVVAPPSVLPFFHFPRFTYYNYGPSPYMTPPYWGFPHPTNSGGDSPRGPQSPLDLDNMLRAMPPNKSVFDVLTSHPGDLVHPSFLSQCLGSSGSPYPSRQGLM

foxh1

Forkhead box protein H1

515 amino acids

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription (By similarity).

56.741 kDa

MRDPSSLYAGFPVGSQYESVEPPSLALLSSIYQEQVPAAPGHSYEQCAQPWPPLYREGGTWSPDRGSMHGLSPGTQEGSCTQAEGTKDSLGGDETLSRKSKKKNYHRYAKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFKGDYMGWKDSIRHNLSSNDCFKKVLKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYKYEHNVVVYAPHHMPSHASSLPLAEDPHQTNTGGKLNTSFMIDSLLNDLQDVDLPDVPRNIESQRISPAVAINNMWSSAPLLYPQSKPTRNGRGPGFSASHSTYSSSSSSISTISPVGFQETQERSEDLLGRQTQRLGFPTKRPREDDGCSTPSSDTDAGNYSPTEPPKKMPLLSLDLPTSYTKSVAPNVVAPPSVLPFFHFPRFTYYNYGPSPYMTPPYWGFPRPTNPGGDSPRGPQTSLDLDNMLKTVPPNKSVFDVLTSHPGDLVHPSFLGQCLGSSGSPYPSRQGLM

foxh1

Forkhead box protein H1

472 amino acids

Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.

51.62 kDa

MTKHWGGPGLLAPPVITVGEGAQRDHHLDCRIGYSSSKRSCHRSSNPLLELGGRLDKSTGMAQDSCYRAKATNQGPWELQDGNSSGGKKKNYQRYPKPPYSYLAMIAMVIQNSPEKKLTLSEILKEISTLFPFFKGNYKGWRDSVRHNLSSYDCFVKVLKDPGKPQGKGNFWTVEVNRIPLELLKRQNTAVSRQDETIFAQDLAPYIFQGYSQPNKSKPLPPESSLPPVPTRQSPPPSEDPYRPKLDSTFAIDSLLHSLRPASSAGEGLRERESWGVGPPPHTRSTTPPRPCNASYNGSSSASSVSPASDFSDEDWRGVTVVGKRSGDRGITSDAYSDSCPPPNKSSKRGNTPPWELPTSYAKYTPPNAVAPPSMRFNGNPFMPLGGIPFYGYGGAHVTTSHLIGHPYWPILPSGPVSIQAPPLLMDLDSMLQSVPPNKSVFDALGSNNQTVHPSPNQYALQNGPSLCKYSL

Foxh1

Forkhead box protein H1

401 amino acids

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

44.001 kDa

MASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYQPPSPPPPPREGFSIKSLLGDPGKESTWPQHPGLPGQSTAAQAGTLSKGEEGMGTGPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLEDSADSRGVPRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPTTSCPQCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM

FOXH1

Forkhead box protein H1

365 amino acids

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

39.257 kDa

MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL