Protein
Forkhead box protein D3-B
Function
Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction. Functions by recruiting the transcriptional corepressor tle4. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene.
Sequence
MTLSSSGSASDMSGQTVLSADDADIDVVGEGDEALDKDSECESPVGHHDEVDALGGKEIPRSPSGSSTDAEGKGESQQQQQEGIQNKPKNSVVKPPYSYIALITMSILQSPQKKLTLSGICEFISSRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRQQQDTLREQTALMMQSFGAYSLASPYGRHYGLHPAAYTHPAALQYPYIPPVGPMLPPAVPLLPSSELTRKAFSSQLSPSLQLQLSSLSSTAASIIKSEPSSRPSFSIENIIGVSAASSVAPQTFLRPPVTVQSALMSHQPLVLSRSTAAIGPILSVPTNLISGQFLPTAATAVAKWPAQ